2022
DOI: 10.1016/j.mce.2021.111466
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Fatty acids in normal and pathological pregnancies

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Cited by 12 publications
(8 citation statements)
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“…Up to date, no studies have explored the potential fatty acid patters that associated with GDM odds through statistical method of dimension reduction like PCA. The results of the few studies that assessed the association of individual fatty acids with incident GDM showed some inconsistency with the present study's findings (9). Reasons for such variability include differences in gestational age at blood sample collection, biological specimen sampled, and the method of fatty acid measurement or expression.…”
Section: Discussioncontrasting
confidence: 98%
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“…Up to date, no studies have explored the potential fatty acid patters that associated with GDM odds through statistical method of dimension reduction like PCA. The results of the few studies that assessed the association of individual fatty acids with incident GDM showed some inconsistency with the present study's findings (9). Reasons for such variability include differences in gestational age at blood sample collection, biological specimen sampled, and the method of fatty acid measurement or expression.…”
Section: Discussioncontrasting
confidence: 98%
“…One case-control study nested in a cohort of US women suggested a beneficial role of odd-chain fatty acids, 22:5n-3 and 22:4n-6 in prevention of GDM, while 16:0, 18:3n-6, and 20:3n-6 at 10-14 weeks of pregnancy were associated with increased risk of GDM (10,11). In normal pregnancy, plasma phospholipids in maternal circulation would increase by nearly 50% as compared to non-pregnant circulation (9), and the composition of plasma fatty acids is expected to fluctuate throughout gestation, which may lead to the discrepancy in the association between individual fatty acids and GDM risk in different trimesters on pregnancy (15,17). Ortega-Senovilla et al found that in the serum of women with GDM, the concentrations of most fatty acids were lower than in control women, except for 20:4n-6 and 22:6n-3, which remained the same.…”
Section: Discussionmentioning
confidence: 99%
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“…This may explain the findings in preeclampsia of accumulation of TUFAs in third-trimester placentas ( Wada et al, 2017 ); significantly increased highly polyunsaturated cholesterol esters, triacylglycerols, and phosphatidylcholines; increased total phospholipids ( Brown et al, 2016 ); and increased sphingomyelin ( Del Gaudio et al, 2020 ). When compared to controls, preeclampsia maternal serum has increased PUFAs ( Al et al, 1995 ; Anand et al, 2016 ; Irwinda et al, 2021 ) with an elevated omega 6:3 ratio ( Williams et al, 1995 ) and increased oxidation of several lipids ( He et al, 2021 ; Mauro et al, 2022 ), while lipids are relatively normal in fetal blood ( van der Schouw et al, 1991 ). The finding of increased de novo synthesis of ceramides in the placenta, increased maternal serum ceramides, and reduced lysosomal breakdown prompted one research group to typify preeclampsia as a sphingolipid storage disease ( Melland-Smith et al, 2015 ).…”
Section: Lipidomics Of Preeclampsiamentioning
confidence: 99%