Fatty degeneration of the rotator cuff: pathogenesis, clinical implications, and future treatment

Bogdanov, Jacob; Lan, Rae; Chu, Timothy N.; Bolia, Ioanna K; Weber, Alexander E.; Petrigliano, Frank A.

doi:10.1016/j.xrrt.2021.05.006

Cited by 7 publications

(6 citation statements)

References 90 publications

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“…WAT phenotypes store energy while BAT phenotypes consume energy. In particular, transplanted BAT-FAPs reduce muscle atrophy and fat in ltration, while also increasing angiogenesis 36 . BAT-FAPs, which speci cally expresse PDGFRα, were found to have the potential to differentiate into myo broblasts or adipocytes, and thus may be responsible for brosis and fatty degeneration after acute and chronic muscle injury.…”

Section: Discussionmentioning

confidence: 99%

Effect of Fibro-adipogenic progenitor for muscle weakness after rotator cuff injury: A scoping review of animal studies

Nihei

Murata

Sone

et al. 2022

Preprint

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Introduction: Muscle weakness rotator cuff tear (RCT) after is the most important factor for physical function. However, the mechanism underlying muscle atrophy and treatment after rotator cuff injury remains to be elucidated. This study sought to systematically review published animal studies to explore effective treatment options for muscle weakness following human rotator cuff injury, focusing on fibro-adipogenic progenitors (FAPs). Materials and methods: MEDLINE, PubMed, and Embase were systematically searched for articles published in June 2022, using relevant keywords. Animal species, injury and repair types, study duration, and fatty degeneration parameters were summarized. Results: Of the 120 studies, 51 were secondarily evaluated for cell treatment of muscle weakness in rotator cuff injury. Finally, six studies examining the effects of FAPs on atrophy were selected for analysis. Six studies showed positive effects on the supraspinatus muscle following FAP (n = 3) or pluripotent stem cell (n = 3) injections. Conclusion: Following the review, we concluded that FAP might be effectively inhibit fatty degeneration after rotator cuff injury. However, mechanical stress also should required for prevention of muscle weakness in various article. Overall, there are few FAP injection reports for RCTs, and basic research should proceed in this direction.

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Section: Discussionmentioning

confidence: 99%

Effect of Fibro-adipogenic progenitor for muscle weakness after rotator cuff injury: A scoping review of animal studies

Nihei

Murata

Sone

et al. 2022

Preprint

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“…19 Several orthopedic conditions are also associated with fatty degeneration of adjacent musculature; eg, chronic rotator cuff pathology after rotator cuff tears is often complicated by degenerative changes such as fat accumulation, which is associated with a poor prognosis. 20 Hip pathologies such as osteoarthritis and total hip arthroplasty are associated with significant atrophy and greater fat infiltration of gluteal muscles. 21 In patients with neuromuscular diseases (NMD), progressive replacement of muscle fibers by adipose tissue occurs during disease progression.…”

Section: Mri Of Fat Infiltrationmentioning

confidence: 99%

Compositional and Functional MRI of Skeletal Muscle: A Review

Hooijmans,

Schlaffke,

Bolsterlee

et al. 2023

Magnetic Resonance Imaging

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Due to its exceptional sensitivity to soft tissues, MRI has been extensively utilized to assess anatomical muscle parameters such as muscle volume and cross‐sectional area. Quantitative Magnetic Resonance Imaging (qMRI) adds to the capabilities of MRI, by providing information on muscle composition such as fat content, water content, microstructure, hypertrophy, atrophy, as well as muscle architecture. In addition to compositional changes, qMRI can also be used to assess function for example by measuring muscle quality or through characterization of muscle deformation during passive lengthening/shortening and active contractions. The overall aim of this review is to provide an updated overview of qMRI techniques that can quantitatively evaluate muscle structure and composition, provide insights into the underlying biological basis of the qMRI signal, and illustrate how qMRI biomarkers of muscle health relate to function in healthy and diseased/injured muscles. While some applications still require systematic clinical validation, qMRI is now established as a comprehensive technique, that can be used to characterize a wide variety of structural and compositional changes in healthy and diseased skeletal muscle. Taken together, multiparametric muscle MRI holds great potential in the diagnosis and monitoring of muscle conditions in research and clinical applications.Evidence Level5Technical EfficacyStage 2

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“…A notable compositional alteration is the replacement of muscle fibers by fat, which is observed in various physiological and pathological conditions, such as aging 5 , 6 , muscle inactivity 7 , 8 , and neuromuscular disorders 3 . Fat infiltration, however, marks an irreversible stage in the degeneration of muscle tissue, limiting its utility to only indicating the chronic or end-stage of muscle degeneration.…”

Section: Introductionmentioning

confidence: 99%

A deep learning approach for fast muscle water T2 mapping with subject specific fat T2 calibration from multi-spin-echo acquisitions

Barbieri,

Hooijmans,

Moulin

et al. 2024

Sci Rep

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This work presents a deep learning approach for rapid and accurate muscle water T2 with subject-specific fat T2 calibration using multi-spin-echo acquisitions. This method addresses the computational limitations of conventional bi-component Extended Phase Graph fitting methods (nonlinear-least-squares and dictionary-based) by leveraging fully connected neural networks for fast processing with minimal computational resources. We validated the approach through in vivo experiments using two different MRI vendors. The results showed strong agreement of our deep learning approach with reference methods, summarized by Lin’s concordance correlation coefficients ranging from 0.89 to 0.97. Further, the deep learning method achieved a significant computational time improvement, processing data 116 and 33 times faster than the nonlinear least squares and dictionary methods, respectively. In conclusion, the proposed approach demonstrated significant time and resource efficiency improvements over conventional methods while maintaining similar accuracy. This methodology makes the processing of water T2 data faster and easier for the user and will facilitate the utilization of the use of a quantitative water T2 map of muscle in clinical and research studies.

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Fatty degeneration of the rotator cuff: pathogenesis, clinical implications, and future treatment

Cited by 7 publications

References 90 publications

Effect of Fibro-adipogenic progenitor for muscle weakness after rotator cuff injury: A scoping review of animal studies

Effect of Fibro-adipogenic progenitor for muscle weakness after rotator cuff injury: A scoping review of animal studies

Compositional and Functional MRI of Skeletal Muscle: A Review

A deep learning approach for fast muscle water T2 mapping with subject specific fat T2 calibration from multi-spin-echo acquisitions

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