Fatty liver disease: the hepatic manifestation of metabolic syndrome

Gastaldelli, Amalia

doi:10.1038/hr.2010.60

Cited by 36 publications

(28 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Fatty Liver Dyslipidemia and The Metabolic Syndromementioning

confidence: 99%

“…It has also been proposed that NAFLD could be considered the hepatic manifestation of metabolic syndrome [61,62]. Prevalence of the metabolic syndrome in NAFLD has been estimated to vary from 18% in normal-weight to 67% in obese subjects [61,62,63,64]. Moreover, liver fat accumulation is very common in type 2 diabetes [7] and a strong link has been observed between abdominal ectopic fat accumulation and the development of hypertension [62,65,66].…”

Section: Fatty Liver Dyslipidemia and The Metabolic Syndromementioning

confidence: 99%

“…Prevalence of the metabolic syndrome in NAFLD has been estimated to vary from 18% in normal-weight to 67% in obese subjects [61,62,63,64]. Moreover, liver fat accumulation is very common in type 2 diabetes [7] and a strong link has been observed between abdominal ectopic fat accumulation and the development of hypertension [62,65,66]. There are plenty of data linking the liver enzymes ALT and GGT (both correlated with liver fat) with incidence of diabetes [67].…”

Section: Fatty Liver Dyslipidemia and The Metabolic Syndromementioning

confidence: 99%

See 2 more Smart Citations

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

et al. 2013

Self Cite

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.

show abstract

Section: Fatty Liver Dyslipidemia and The Metabolic Syndromementioning

confidence: 99%

Section: Fatty Liver Dyslipidemia and The Metabolic Syndromementioning

confidence: 99%

Section: Fatty Liver Dyslipidemia and The Metabolic Syndromementioning

confidence: 99%

See 1 more Smart Citation

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has also been hypothesized that NAFLD might be thehepatic feature of MetS (71). The pathogenesis of MetS and NAFLD are incompletely understood.…”

Section: Resultsmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease/Non-Alcoholic Steatohepatitis in Childhood: Endocrine-Metabolic “Mal-Programming”

et al. 2014

View full text Add to dashboard Cite

Context:Nonalcoholic Fatty Liver Disease (NAFLD) is the major chronic liver disease in the pediatric population. NAFLD includes a broad spectrum of abnormalities (inflammation, fibrosis and cirrhosis), ranging from accumulation of fat (also known as steatosis) towards non-alcoholic steatohepatitis (NASH). The development of NAFLD in children is significantly increased.Evidence Acquisition:A literature search of electronic databases was undertaken for the major studies published from 1998 to today. The databases searched were: PubMed, EMBASE, Orphanet, Midline and Cochrane Library. We used the key words: "non-alcoholic fatty liver disease, children, non-alcoholic steatohepatitis and fatty liver".Results:NAFLD/NASH is probably promoted by “multiple parallel hits”: environmental and genetic factors, systemic immunological disorders (oxidative stress, persistent-low grade of inflammation) as well as obesity and metabolic alterations (insulin resistance and metabolic syndrome). However its exact cause still underdiagnosed and unknown.Conclusions:Pediatric NAFLD/NASH is emerging problem. Longitudinal follow-up studies, unfortunately still insufficient, are needed to better understand the natural history and outcome of NAFLD in children. This review focuses on the current knowledge regarding the epidemiology, pathogenesis, environmental, genetic and metabolic factors of disease. The review also highlights the importance of studying the underlying mechanisms of pediatric NAFLD and the need for complete and personalized approach in the management of NAFLD/NASH.

show abstract

“…Non-alcoholic fatty liver disease (NAFLD) is a relevant metabolic disorder with a high evolutional potential, including from isolated hepatic steatosis to non-alcoholic steatohepatitis (NASH), and if left untreated, can progress to fibrosis, cirrhosis and even liver failure[ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Anthropometric indicators of visceral adiposity as predictors of non-alcoholic fatty liver disease: A review

Almeida

Rocha

Cotrim

et al. 2018

WJH

View full text Add to dashboard Cite

The objective was to critically analyze studies that evaluated the predictive capacity of indicators of visceral adiposity in non-alcoholic fatty liver disease (NAFLD). The bibliographic research was carried out using the electronic database PubMed, LILACS and SciELO, references of selected articles. Although we found few studies, they have already used several indicators of visceral adiposity as waist circumference, waist-to-hip ratio, waist-to-height ratio, Lipid accumulation product, Body Shape Index, Body Roundness Index and most them were good predictors of NAFLD. Thus, the anthropometric indicators may contribute for the diagnosis of NAFLD in a simple, low-cost and non-invasive way, allowing early therapeutic measures to prevent the evolution to non-alcoholic steatohepatitis.

show abstract

Fatty liver disease: the hepatic manifestation of metabolic syndrome

Cited by 36 publications

References 11 publications

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

Nonalcoholic Fatty Liver Disease/Non-Alcoholic Steatohepatitis in Childhood: Endocrine-Metabolic “Mal-Programming”

Anthropometric indicators of visceral adiposity as predictors of non-alcoholic fatty liver disease: A review

Contact Info

Product

Resources

About