Fatty Liver Induced by Orotic Acid Feeding

Standerfer, Susan B.; Handler, Philip

doi:10.3181/00379727-90-22005

Cited by 119 publications

(39 citation statements)

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“…Dietary orotic acid produces severe fatty liver (1)(2)(3). The activities of both ornithine carbamoyltransferase (EC 2.1.3.3) and alanine aminotransferase (EC 2.6.1.2) in serum significantly increased when rats were fed the orotic acid diet, as previously reported (4,5).…”

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confidence: 68%

“…In the formation of fatty liver induced by dietary orotic acid, casein has generally been used as a sole di etary protein source (1)(2)(3)(4)(5). Therefore the effects of an orotic acid supplement to a diet containing casein were compared with other diets containing egg protein, soy protein, or wheat gluten, indicating that the content of liver triacylglycerol in rats fed the casein diet supple mented with orotic acid was significantly higher than those of rats fed the egg protein, soy protein, or wheat gluten diet supplemented with orotic acid (6,7).…”

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confidence: 99%

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Dietary Orotic Acid Increases 1,2-Diacylglycerol Level and Lowers Superoxide Dismutase Activity in Rat Liver.

Aoyama

Morifuji

2002

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of the dietary addition of orotic acid were studied on lipid levels in the rat liver and serum, 1,2-diacylglycerol levels in some organs, activities of antioxidant liver enzymes (superoxide dismutase, glutathione peroxidase, and catalase), and serum en zyme activities (ornithine carbamoyltransferase and alanine aminotransferase), after feed ing for 0, 7, 14, and 21d, respectively. Rats on the orotic acid diet accumulated more liver total lipids, triacylglycerol, and phospholipids than those on the basal diet. However, the lev els of serum triacylglycerol and phospholipids of those rats were markedly decreased after 7 , 14, and 21d on the diet. Dietary orotic acid increased the 1,2-diacylglycerol levels in the liver of rats fed for 14 or 21d, but not in the ileum of small intestine, vastus lateralis muscle , and heart. The addition of orotic acid lowered the activities of liver total and Cu,Zn-superox ide dismutase after feeding for 7, 14, and 21d. The serum ornithine carbamoyltransferase activity after 14, and 21d and that of serum alanine aminotransferase after 7, 14, and 21d were increased. These data suggested that the increase in the activities of serum enzymes tested may result from liver damage induced by the marked accumulation of liver lipids and possibly from the increased superoxide anion because of the decreased activities of hepatic superoxide dismutase by orotic acid feeding.

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supporting

confidence: 68%

mentioning

confidence: 99%

Dietary Orotic Acid Increases 1,2-Diacylglycerol Level and Lowers Superoxide Dismutase Activity in Rat Liver.

Aoyama

Morifuji

2002

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Standerfer et al (9) reported on the development of fatty livers in animals maintained on a diet containing 1% orotic acid, and Handschumacher et al (10) postulated such symptoms to be induced by an unbalance of nucleic acid meta bolism, since they can be prevented by a diet supplemented with adenine.…”

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confidence: 99%

Effects of Nucleic Acid Precursors on Liver Injuries

Hashimoto

1967

J. Vitaminol

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“…The administration of large amounts of orotic acid induces fatty liver 7) and liver injuries. 8) Furthermore, it has been reported that increased triglyceride synthesis mediated by changes in liver phosphatidate phosphohydrolase activity was involved in the hepatic triglyceride accumulation induced by orotic acid administration and that this change was markedly suppressed by dietary n-3 fatty acids.…”

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confidence: 99%