For detecting the weak fault diagnosis submerged in heavy noise, a new method called multi-scale cascaded multi-stable stochastic resonance (MCMSR) is studied. The method can effectively extract weak fault diagnosis from noise background using multi-scale wavelet noise tuning stochastic resonance (SR). Firstly, input signal with noise is decomposed by multi-scale wavelets transformation, and each scale signal is adjusted by scaling factor, then the decomposed signal is used as the input of cascaded multi-stable systems to achieve the detection of fault diagnosis. If the input signal is a large parameter signal, to conform to the conditions of SR, the decomposed signal must be processed by twice sampling. The simulation and experimental signals are carried out to test the feasibility of the method. From the signal to noise ratio (SNR) comparison curves of original signal, SR output signal and MCMSR output signal plotted together, we can find that the useful signal can be enhanced by MCMSR method than SR method. The experimental results indicate that the MCMSR can extract fault diagnosis from heavy background noise.