Favorable Clinical Outcomes of Transcatheter Aortic Valve Implantation in Japanese Patients　― First Report From the Post-Approval K-TAVI Registry ―

Comparison of Transcarotid vs. Transfemoral Transcatheter Aortic Valve Implantation

“…13 Most previous studies reported better results with the TF than transapical approach. 20 Sawa et al 21 reported that 6-month all-cause mortality, cardiac mortality, and 5-year cardiac mortality were higher with transapical TAVI than TF-TAVI, and suggested that these outcomes were related to a higher learning curve with transapical TAVI. Kirker et al 6 compared TF, transapical, and TC approaches and found that the transapical approach was inferior to the other approaches because it was associated with significantly higher in-hospital mortality and stroke rates (16.7% and 8.0%, respectively).…”

Ventilatory Efficacy After Transcatheter Aortic Valve Replacement Predicts Mortality and Heart Failure Events in Elderly Patients

“…8 The K-TAVI registry, which maintains data from a previous study of transfemoral TAVR in Japan, reported 1-year survival rates of 95.5% for elderly patients aged 84.8±6.0 years, of whom 35.5% were male and among whom the STS score was 7.4±5.8%. 7 The PREVAIL JAPAN study reported 6-month mortality rates of 5.6% for elderly patients aged 83.2±6.5 years, of whom 35.1% were male and among whom the STS score was 7.79±3.43%. 6 In our present study, which also enrolled elderly Japanese patients (83±5 years) who underwent transfemoral TAVR, 30% of patients were male, the STS score was 6.23±2.84, and the 6-and 12-month mortality rates were 6% and 11%, respectively.…”

“…1,2 However, the 1-year mortality rates after TAVR vary widely and remain high (5-24%). [3][4][5][6][7][8] The Society of Thoracic Surgeons (STS) score is a well-known predictor of death and perioperative complications, 9 but does not provide sufficiently accurate predictions in aged patients who undergo TAVR. [10][11][12] Peak oxygen uptake (V O2) is one of the most important predictors of death in cardiac patients regardless of cardiovascular disease, 13 because it is regulated by multiple factors such as cardiac function, skeletal muscle function, autonomic nerve function, anemia, and vascular function, which are deteriorated in heart failure (HF).…”

Transcatheter Aortic Valve Implantation vs. Surgical Aortic Valve Replacement for Severe Aortic Stenosis in Real-World Clinical Practice

“…The selection of patients and the procedures of the K-TAVI Registry are detailed elsewhere. 31 In the present study, we enrolled 449 patients from the K-TAVI Registry who had undergone TAVI with SAPIEN XT balloon-expandable valves (Edwards Lifesciences, Irvine, CA, USA) between October 2013 and June 2016. The age distribution of patients was quite different between the SAVR and TAVI groups; thus, in the present study, we excluded 111 patients aged <80 or >90 years because age overlap in the TAVI and SAVR patients was mostly seen in the age 80-90 years range ( Supplementary Figure 1).…”