Favorable immune phenotype predicts successful implantation and pregnancy

Chernyshov, Viktor P.; Dons’koi, Boris V.; Sudoma, I.; Goncharova, Y.

doi:10.1016/j.imlet.2014.10.022

Cited by 21 publications

(23 citation statements)

References 35 publications

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“…Patients with recurrent spontaneous abortions revealed significantly increased TH1/TH2-ratios [38]. Additionally decreased numbers of CD4-positive T-cells were associated with unsuccessful IVF-treatments [40] as well as increased numbers of NK-cells [6,[41][42]. For the latter a tendency could be shown in our study: patients without IVF-success revealed increased NK-cell numbers, but these were statistically not significant.…”

Section: Discussioncontrasting

confidence: 64%

“…In this study, similar to our data, the number of parameters in a critical range were determined for each patient. With increasing numbers of parameters the probability of IVFsuccess decreased [40]. Additionally it was shown that the combination of critical blood parameters was of better prognostic value than the use of single parameters.…”

Section: Discussionmentioning

confidence: 97%

“…An approach using blood profiles of fertility patients in order to give a prognosis for the further course of pregnancy was published recently [40]. Increased expression of CD56 and CD158a in T-lymphocytes, decreased numbers of CD4positive T-cells, increased expression of HLA-DR in Tsuppressor and NK-cells, increased numbers of NK-cells, increased expression of CD158a and decreased expression of CD8 in NK-cells were described as negative prognostic markers for the further course of fertility treatment.…”

Section: Discussionmentioning

confidence: 99%

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Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Bareksei¹,

Häfner²,

Pfeiffer³

et al. 2019

IJCEMS

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A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of invitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Bareksei¹,

Häfner²,

Pfeiffer³

et al. 2019

IJCEMS

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“…A combination of ID may predict implantation failure to a greater degree than isolated ID. Multiple immune deviations form an unfavorable “immune phenotype” for implantation and pregnancy development [20].…”

Section: Introductionmentioning

confidence: 99%

Comparison of T and NK lymphocyte subsets between human endometrial tissue and peripheral blood

Chernyshov

Dons’koi

Sudoma

et al. 2019

cejoi

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Immune profiles in endometrium may be changed in patients with IVF failure and its possible correlations with immune parameters in peripheral blood are important for the diagnostic approach. Such correlations in healthy women are unknown and have been studied in the present research. The expression of CD56, CD158a, HLA DR, CD69 in T lymphocytes, CD4 T lymphocytes, CD8+ T lymphocytes and NK cells were studied by flow-cytometry in endometrium and peripheral blood in healthy 24 donors of oocytes aged 25-32 years. Levels of T lymphocyte and T helper cells were lower in endometrium and no differences in CD8 T lymphocytes were registered between endometrium and peripheral blood. The expression of HLA DR and especially CD69 was higher in CD3, CD4, CD8 T cells in endometrium in comparison with peripheral blood. The endometrium lymphocyte population was enriched by NK cells that were generally CD56++ with a higher expression of HLA DR and almost in total were CD69 positive. Strong positive correlations of CD8 expression in NK cells (r = 0.6478, p < 0.001) and HLA DR expression in CD8 T cells (r = 0.6107, p < 0.01) between peripheral blood and endometrium were registered in fertile women. The endometrial CD56 expression in CD8+ T cells negatively correlated with endometrial CD8 expression in NK cells (r = –0.5252, p < 0.01) which possibly reflected a suppressive and regulating mechanism in the endometrium. CD8+ NK cells and HLA DR+ CD8 T cells in endometrium were related to the same subsets in peripheral blood.

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“…Розподіл рівнів природних кілерних лімфоцитів (А) і цитотоксичної активності природних кілерних лімфоцитів (В) серед пацієнтів: А -кількість природних кілерів як % (CD56+CD3-) клітин від усіх лімфоцитів (n = 2804); В -цитотоксичність природних кілерів за співвідношення ефектор/мішень (15/1) визначали методом проточної цитометрії протипухлинної лінії K562 (n = 9535). * -oптимальні значення для успішного перебігу вагітності [1]; ** -oптимальні значення для успішного перебігу вагітності[8,18]; *** -oптимальні значення для імплантації ембріона й успішного перебігу вагітності(5,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) [3-5]; **** -референтні межі для молодих здорових жінок (4,8-26,1%)[16,27]; @ -oптимальні значення для імплантації ембріона й успішного перебігу вагітності (12,5-41 %)[3][4][5]…”

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Numbers of natural killers lymphocytes do not determine their cytotoxicity

Dons’koi¹

2019

Biol. Stud.

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Favorable immune phenotype predicts successful implantation and pregnancy

Cited by 21 publications

References 35 publications

Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Comparison of T and NK lymphocyte subsets between human endometrial tissue and peripheral blood

Numbers of natural killers lymphocytes do not determine their cytotoxicity

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