FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis

Fu, Yu; Lin, You-Cheng; Zhao, Yang; Yang, Guosheng; Li, Gaoyuan; Liu, Yuejia; Tan, Xi; Huang, Yi; Wu, Xun; Wang, Yongqiang; Xiong, Hu; Zhang, Meng; Lü, Fang; Ge, Yukun; Zeng, Jun; Cai, Yangke; Bai, Jian; Wu, Song

doi:10.1007/s12032-015-0656-1

Cited by 15 publications

(12 citation statements)

References 21 publications

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“…The prognostic significance of low FBXW7 expression has been reported in many types of solid tumors, such as breast, colorectal, cervical, and renal cancers. 12,13,38,39 We also observed that low FBXW7 expression was associated with shorter OS among patients with advanced OSCC, and for the first time, we demonstrated this relationship among patients with OSCC who underwent CRT. As the FBXW7 expression levels were significantly associated with the pathological response to preoperative CRT (Table 1), the difference in OS between the groups in the multivariate analysis may be partially due to the different responses to preoperative CRT in the groups with low and high FBXW7 expression.…”

Section: Discussionsupporting

confidence: 65%

FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study

et al. 2017

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FBXW7 (F-box and WD repeat domain containing-7) is a tumor suppressor protein that regulates the degradation of various oncoproteins in several malignancies. However, limited information is available regarding FBXW7 expression in oral squamous cell carcinoma. Therefore, this study aimed to determine the clinical significance of FBXW7 expression in oral squamous cell carcinoma. The FBXW7 expression patterns in oral squamous cell carcinoma and adjacent normal tissues from 15 patients who underwent radical resection were evaluated using quantitative real-time polymerase chain reaction and immunohistochemical staining. In addition, immunohistochemistry was performed using paraffin-embedded sections from biopsy specimens obtained from 110 patients with oral squamous cell carcinoma who underwent surgery after 5 fluorouracil-based chemoradiotherapy. The associations of FBXW7 expression with various clinicopathological features and prognosis were evaluated in these patients. As a results, in the 15 matched samples, the FBXW7 expression was significantly decreased in the oral squamous cell carcinoma tissues compared to that in the adjacent normal tissues. In the clinicopathological analysis, compared to high protein expression, low FBXW7 expression was found to significantly associate with a poor histological response to preoperative chemoradiotherapy. Kaplan-Meier curve analysis revealed that low FBXW7 expression was significantly associated with a poor prognosis, and FBXW7 expression was found to be an independent predictor of overall survival in the multivariate analysis. Our results suggest that FBXW7 may function as a tumor suppressor protein in oral squamous cell carcinoma. In addition, FBXW7 could be a potential biomarker for predicting not only the clinical response to chemoradiotherapy but also overall survival in patients with oral squamous cell carcinoma.

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Section: Discussionsupporting

confidence: 65%

FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study

et al. 2017

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“…Of note, FBXW7 functions as a tumor suppressor in various types of human cancers, due to its capability to suppress cell growth, invasion and migration [31][32][33]. For example, FBXW7 overexpression can lead to the reduction in cell proliferation, migration and invasion in renal cancer [34], HCC [35], and gastric cancer [36]. In OC, FBXW7 was down-regulated in the OC tissues, and its low expression was negatively correlated with the malignant potential of OC [37].…”

Section: Discussionmentioning

confidence: 99%

Astragalus polysaccharides inhibit ovarian cancer cell growth via microRNA-27a/FBXW7 signaling pathway

et al. 2020

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Astragalus polysaccharide (APS), a natural antioxidant found in Astragalus membranaceus emerging as a novel anticancer agent, exerts antiproliferative and pro-apoptotic activity in various cancer cell types, but its effect on ovarian cancer (OC) remains unknown. In the present study, we tried to elucidate the role and mechanism of APS in OC cells. Our results showed that APS treatment suppressed the proliferation and induced apoptosis in OC cells. Afterward, the microRNA (miRNA) profiles in APS-treated cells were determined by a microarray assay, and whether APS affected OV-90 cells through regulation of miRNA was determined. Among these aberrant miRNAs, miR-27a was selected for further study as its oncogenic roles in various human cancers. Moreover, we found overexpression of miR-27a reversed the antiproliferation and pro-apoptotic effects of APS on OC cells. F-box and WD-40 domain protein 7 (FBXW7), a classical tumor suppressor, was found directly targeted by miR-27a and its translation was suppressed by miR-27a in OC cells. Finally, it was also observed that knockdown of FBXW7 by si-FBXW7 reversed the tumor suppressive activity of APS in OC cells, which is similar to the effects of miR-27a overexpression. Our findings demonstrate that APS can suppress OC cell growth in vitro via miR-27a/FBXW7 axis, and this observation reveals the therapeutic potential of APS for treatment of OC.

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“…As previously described, another primary reason for MDR is to reduce susceptibility to drug-induced apoptosis (21,22). Fu et al (35) confirmed that a reduced expression of JUN contributes to an extended G1 phase and induces apoptosis. In addition, activating MYC has been proved to generate apoptosis by triggering cytochrome c before activating caspase (36).…”

Section: Discussionmentioning

confidence: 71%

miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1

et al. 2016

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Routine chemotherapy as an important treatment mode often can not be effective because of multidrug resistance (MDR). MicroRNA (miRNA) modulates the expression of a great number of genes, including MDR. In this study, the expression of miR-1284 was reduced in gastric cancer (GC) tissue specimens with metastasis and in vincristine-resistant (VCR) GC SGC7901 cells (SGC-7901/VCR) compared to that in the controls. Recombinant lentiviral vectors with miR-1284 led to the overexpression of miR-1284 mRNA and reversed the chemoresistance of SGC7901/VCR cells, promoted cell cycle arrested at the G0/G1 phase, accelerated drug-induced apoptosis, and decreased migration and invasiveness of SGC-7901/VCR. In addition, the overexpression of miR-1284 sensitized tumors to chemotherapy in vivo. Our data provide combined evidence that miR-1284 can heighten the expression of MYC and reduce the expression of JUN, MMP12, and EIF4A1 that was the direct target. In conclusion, miR-1284 can function as a new regulator to reduce GC MDR cells by targeting EIF4A1.

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FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis

Cited by 15 publications

References 21 publications

FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study

FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study

Astragalus polysaccharides inhibit ovarian cancer cell growth via microRNA-27a/FBXW7 signaling pathway

miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1

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