FcεRI engagement of Langerhans cell–like dendritic cells and inflammatory dendritic epidermal cell–like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro☆

Novak, Natalija; Valenta, Rudolf; Bohle, Barbara; Laffer, Sylvia; Haberstok, Jörg; Kraft, Stefan; Bieber, Thomas

doi:10.1016/j.jaci.2004.02.005

Cited by 173 publications

(167 citation statements)

References 33 publications

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“…IDECs are found mainly in the inflamed regions of the skin, where they produce large amounts of cytokines after FcεRI cross-linking, which aggravates the inflammatory state. Activation of IDECs' FcεRI causes secretion of IL-12, whose presence increases the Th1 immune response in the skin [8]. The described mechanisms explain the development of eczematous lesions in the aftermath of exposure to protein allergens.…”

Section: Wprowadzeniementioning

confidence: 90%

“…Przypuszcza się, że przewaga limfocytów Th1 w przewlekłych zmianach skórnych może być wynikiem działania IL-12. Jest ona uwalniana przez eozynofile, których napływ do ognisk zapalnych w skórze stymulują cytokiny uwalniane przez limfocyty Th2 [7], a także przez zapalne komórki dendrytyczne naskórka (IDECs) napływa-jące do naskórka w trakcie zapalenia [8]. Wykazano także w krwi obwodowej chorych na AD podwyż-szone stężenie Th17, natomiast w wycinkach skór-Dermatology Review/Przegląd Dermatologiczny 2017/2 thesized by these lymphocytes activate the expression of antimicrobial peptides (AMP), TNF-α and IL-8 in the epidermis, which escalates the inflammatory state [10].…”

Section: Wprowadzenieunclassified

“…IDEC występują głównie w skórze zmienionej zapalnie, gdzie produkują liczne cytokiny prozapalne na skutek aktywacji receptorów FcεRI, co dodatkowo zaostrza stan zapalny. Aktywacja receptora FcεRI na powierzchni IDEC powoduje wydzielanie IL-12, które wpływają na zwiększenie odpowiedzi typu Th1 w skó-rze [8]. Opisany mechanizm tłumaczy rozwój zmian wypryskowych pod wpływem alergenów białkowych.…”

Section: Wprowadzenieunclassified

“…It has been postulated that the dominance of Th1 lymphocytes in chronic skin lesions may be secondary to effects mediated by IL-12. IL-12 is released by eosinophils, whose influx is stimulated by Th2 lymphocytes [7] as well as by the inflammatory dendritic epidermal cells (IDECs) [8]. Peripheral blood samples of AD patients have shown an increased Th17 concentration, while skin samples reveal presence of these cells only during acute inflammation [9].…”

Section: Introductionmentioning

confidence: 99%

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Contact hypersensitivity to nickel in patients with atopic dermatitis

Rożalski¹,

Blicharz²,

Samochocki³

2017

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Atopic dermatitis is a chronic, recurrent inflammatory dermatosis with a complex and not fully explained pathogenesis. Recent years' research points to a significant percentage of patients with atopic eczema in whom hapten patch test results are positive, especially with respect to nickel. These observations undermine suggestions that contact allergy (type IV hypersensitivity) is rare in this group due to the dominance of the Th2-type cellular response characteristic for type I allergic reactions. In this review we aimed to systematize current knowledge regarding the pathomechanisms of contact hypersensitivity to nickel in patients with atopic dermatitis and the potential influence of this hapten on the clinical course of the disease. STRESZCZENIEAtopowe zapalenie skóry jest przewlekłą, nawrotową dermatozą zapalną o złożonej, nie w pełni wyjaśnionej etiopatogenezie. Badania z ostatnich lat wskazują na istotny odsetek chorych na wyprysk atopowy, u których stwierdza się dodatnie wyniki płatkowych testów kontaktowych z haptenami, głównie z niklem. Obserwacje te przeczą sugestii, że w tej grupie pacjentów alergia kontaktowa (IV mechanizm nadwrażliwości) jest rzadkim zjawiskiem ze względu na przewagę odpowiedzi komórkowej typu Th2, typowej dla I mechanizmu nadwraż-liwości. W poniższej pracy autorzy podjęli próbę usystematyzowania dotychczasowej wiedzy o patomechanizmie rozwoju nadwrażliwości kontaktowej na nikiel u chorych na atopowe zapalenie skóry i ewentualnym wpływie tego haptenu na kliniczny przebieg schorzenia.

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Section: Wprowadzeniementioning

confidence: 90%

Section: Wprowadzenieunclassified

Section: Introductionmentioning

confidence: 99%

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Contact hypersensitivity to nickel in patients with atopic dermatitis

Rożalski¹,

Blicharz²,

Samochocki³

2017

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“…61 A new antimicrobial peptide namely, human β-defensin 3 has AD and prime naïve T cells to the Th2 type. 82 Triggering of the FcεRI receptor on the surface of LCs by allergens induces chemotactic signals and recruits precursor cells of IDECs and T cells in vitro. Engagement of FcγRI on IDECs further induces proinflammatory signals amplifying the immune response.…”

Section: B Infectious Triggersmentioning

confidence: 99%

Clinical correlations of recent developments in the pathogenesis of atopic dermatitis

Sehra

Tuana

Holbreich

et al. 2008

An. Bras. Dermatol.

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Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence affecting 10-20 % of infants and 1-3% of adults globally. It is often the first clinical manifestation of atopic disease preceding asthma and allergic rhinitis. Probably half of the children with atopic dermatitis develop some other form of atopic disease later in life. The pathogenesis involves a complex interplay of factors including genetic predisposition due to altered immune or skin barrier function, interactions with the environment such as food and allergen exposures, and infectious triggers of inflammation. In this review, we summarize the recent advances in understanding the contribution of different factors in the pathophysiology of atopic dermatitis and how insights provide new therapeutic potential for its treatment. Keywords: Asthma; Atopic Dermatitis, Eczema; Eosinophils; Genetics; Immunoglobulin E; Keratinocytes; Rhinitis, T-Lymphocytes Resumo: A dermatite atópica é uma doença cutânea inflamatória crônica cuja prevalência tem aumentado de forma constante, afetando 10-20% dos lactentes e 1-3% dos adultos em todo o mundo. Ela é freqüentemente a primeira manifestação clínica de doença atópica, precedendo a asma e a rinite alérgica. Provavelmente metade das crianças com dermatite atópica desenvolvem alguma

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