FcεRI-HDAC3-MCP1 Signaling Axis Promotes Passive Anaphylaxis Mediated by Cellular Interactions

Kim, Mi-Sun; Kwon, Yoojung; Jung, Hyun Suk; Kim, Youngmi; Jeoung, Dooil

doi:10.3390/ijms20194964

Cited by 12 publications

(10 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While activation of the pathways associated with multiple inflammatory cytokines, including IL-2, IL-6, IL-10, and TNFRI, were observed during anaphylaxis [ 6 , 9 ], the selective CCL2 chemokine cascade might be important for chemotactic activity during anaphylactic reactions. It was recently reported that the CCL2-FcεRI-histone deacetylase 3 signalling axis mediates passive anaphylaxis by increasing the expression of CCL2 in mast cells [ 28 , 29 ]. After allergen stimulation, histone deacetylase 3 binds to FcεRI, and histone deacetylase 3 increases the expression of SP1 and C-Jun, which bind to the promoter sequences of CCL2 to increase the expression of CCL2 [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…It was recently reported that the CCL2-FcεRI-histone deacetylase 3 signalling axis mediates passive anaphylaxis by increasing the expression of CCL2 in mast cells [ 28 , 29 ]. After allergen stimulation, histone deacetylase 3 binds to FcεRI, and histone deacetylase 3 increases the expression of SP1 and C-Jun, which bind to the promoter sequences of CCL2 to increase the expression of CCL2 [ 28 , 29 ]. Conversely, in the absence of allergen stimulation, histone deacetylase 3 binds to the promoter sequences of CCL2 to suppress the expression of CCL2 [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils

Vantur

Rihar

Koren

et al. 2020

Clin Transl Allergy

View full text Add to dashboard Cite

Background The role of chemokines in anaphylaxis is unclear. Methods We prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the absolute number of circulating basophils, monocytes, lymphocytes, and PMNs, and whole blood FCER1A, CPA3 and HDC gene expression at two time points: during the anaphylactic episode and in convalescent samples collected approximately 3 months later. We then investigated the in vitro chemotactic activity of chemokines induced during anaphylaxis for the in vitro migration of the corresponding cells. Results Only CCL2 chemokine levels were significantly increased in anaphylaxis samples (median 514 pg/ml) compared to convalescent samples (284 pg/ml, P < 0.0001) and healthy subjects (279 pg/ml, P < 0.0001); there was no significant difference in any of the other chemokines. There was a significant positive correlation between the rates of increase of serum CCL2 (median [range]: 106.0% [− 44.7% to 557.4%]) and tryptase (133.8% [− 6.6% to 893.4%]; r = 0.68, P < 0.0001) and between the acute concentration of serum CCL2 and the acute concentration of serum tryptase (r = 0.77, P < 0.0001). The number of circulating basophils, but not other blood cells, significantly decreased during anaphylaxis (median 5.0 vs. 19.1 cells/µl in convalescent samples; P < 0.0001); a decrease in whole-blood gene expression of basophil markers (P ≤ 0.0018) confirmed these changes. Anaphylactic serum enhances the in vitro migration of basophils via CCL2-dependent chemotactic activity; in contrast, no CCL2-dependent chemotactic activity was observed for convalescent samples. Conclusions Our findings imply an important and specific role for CCL2-mediated chemotactic activity in the pathophysiology of human anaphylaxis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils

Vantur

Rihar

Koren

et al. 2020

Clin Transl Allergy

View full text Add to dashboard Cite

show abstract

“…It was previously defined that, in the absence of allergen, histone deacetylase 3 binds to the promoter sequences of CCL2 to suppress CCL2 expression. Upon allergen stimulation, histone deacetylase 3 binds to FcεRI, and mediates passive anaphylaxis by increasing the expression of CCL2 in mast cells [ 33 ].…”

Section: Proinflammatory Mediators Involved In Anaphylaxismentioning

confidence: 99%

Anaphylaxis: Focus on Transcription Factor Activity

Guo

Proaño-Pérez

Muñoz-Cano

et al. 2021

IJMS

View full text Add to dashboard Cite

Anaphylaxis is a severe allergic reaction, rapid in onset, and can lead to fatal consequences if not promptly treated. The incidence of anaphylaxis has risen at an alarming rate in past decades and continues to rise. Therefore, there is a general interest in understanding the molecular mechanism that leads to an exacerbated response. The main effector cells are mast cells, commonly triggered by stimuli that involve the IgE-dependent or IgE-independent pathway. These signaling pathways converge in the release of proinflammatory mediators, such as histamine, tryptases, prostaglandins, etc., in minutes. The action and cell targets of these proinflammatory mediators are linked to the pathophysiologic consequences observed in this severe allergic reaction. While many molecules are involved in cellular regulation, the expression and regulation of transcription factors involved in the synthesis of proinflammatory mediators and secretory granule homeostasis are of special interest, due to their ability to control gene expression and change phenotype, and they may be key in the severity of the entire reaction. In this review, we will describe our current understanding of the pathophysiology of human anaphylaxis, focusing on the transcription factors’ contributions to this systemic hypersensitivity reaction. Host mutation in transcription factor expression, or deregulation of their activity in an anaphylaxis context, will be updated. So far, the risk of anaphylaxis is unpredictable thus, increasing our knowledge of the molecular mechanism that leads and regulates mast cell activity will enable us to improve our understanding of how anaphylaxis can be prevented or treated.

show abstract

“…Permeability and anti-inflammatory effects of lornoxicon in nanoemulsions (100–200 nm) are greatly increased. Use of aspirin- or capsaicin-derived nanoemulsion reveals excellent skin penetration and permeation which is proven by laser scanning microscopy analysis [70].…”

Section: Skin Inflammationmentioning

confidence: 99%

“…Thereby, modulate activity of neurons increases SP releases from unmyelinated nerve endings of the skin, and later degranulation of cutaneous mast cells occurs [69]. A study on rats by Kim et al, [70] specified that use of siTNFα in assemblage with 2.5 mg of capsaicin nanoparticle encapsulation for 5 days yielded complete treatment of inflamed versus normal looking skin.…”

Section: Skin Inflammationmentioning

confidence: 99%

Capsaicin: Plants of the Genus Capsicum and Positive Effect of Oriental Spice on Skin Health

Basharat

Gilani

Iftikhar

et al. 2020

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Background: Capsaicin, the main pungent ingredient in hot chili peppers, causes excitation of small sensory neurons. It also provides the basic pungent flavor in Capsicum fruits. Summary: Capsaicin plays a vital role as an agonist for the TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential for the reduction of oxidative stress, pain sensations, and inflammation. Therefore, it has many pros related to health issue. Activation and positive impact of TRPV1 via capsaicin has been studied in various dermatological conditions and in other skin-related issues. Past studies documented that capsaicin plays a vital role in the prevention of atopic dermatitis as well as psoriasis. Moreover, TRPV1 is also very important for skin health because it acts as a capsaicin receptor. It is found in nociceptive nerve fibers and nonneural structures. It prompts the release of a compound that is involved in communicating pain between the spinal cord nerves and other parts of the body. Key Messages: Here, we summarize the growing evidence for the beneficial role of capsaicin and TRPV1 and how they help in the relief of skin diseases such as inflammation, permeation, dysfunction, atopic dermatitis, and psoriasis and in pain amplification syndrome.

show abstract

FcεRI-HDAC3-MCP1 Signaling Axis Promotes Passive Anaphylaxis Mediated by Cellular Interactions

Cited by 12 publications

References 130 publications

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils

Anaphylaxis: Focus on Transcription Factor Activity

Capsaicin: Plants of the Genus <b><i>Capsicum</i></b> and Positive Effect of Oriental Spice on Skin Health

Contact Info

Product

Resources

About