Fcσ RECEPTORS AND IgG ASSOCIATED WITH HUMAN MALIGNANT TUMOURS

Wesenberg, Finn

doi:10.1111/j.1699-0463.1978.tb02589.x

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…No definite evidence was obtained for IgC bound to FcR in cancer tissue, extending previous results (7). This may indicate that the IgC is bound to antigens.…”

Section: Discussionsupporting

confidence: 71%

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IgG AND OTHER PROTEINS ASSOCIATED WITH HUMAN CARCINOMAS AND CANCER‐FREE TISSUE FROM THE SAME ORGANS

Wesenberg

Tönder

1980

Acta Pathologica Microbiologica Scandinavica Section C Immunolo

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Eluates of different tissues were prepared at 56°C using a continuous flow technique. More IgG and other serum proteins were found in liver tissue from patients with non‐malignant diseases than in liver tissue from healthy control individuals. Cancer‐free liver tissue from patients with carcinomas was similar to that of patients with non‐malignant diseases, but liver metastases contained twice the amount of IgG. No differences were found between non‐perfused carcinomas of the kidney and cancer‐free renal tissue, whereas more IgG was present in perfused carcinomas of the kidney than in cancer‐free renal tissue. Most eluates of the malignant tissues and of the cancer‐free renal tissue showed a reduced ratio of albumin to IgG compared to that of serum or extracts, indicating a binding of IgG to antigens and/or receptors.

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“…No definite evidence was obtained for IgC bound to FcR in cancer tissue, extending previous results (7). This may indicate that the IgC is bound to antigens.…”

Section: Discussionsupporting

confidence: 71%

“…FcRA in tissue sections was demonstrated as previously (7). using the microculture (hanging drop) slide technique (5).…”

Section: Fcy Receptor Acti1'itv (Fcr a ) In Tissue Sectionsmentioning

confidence: 98%

IgG AND OTHER PROTEINS ASSOCIATED WITH HUMAN CARCINOMAS AND CANCER‐FREE TISSUE FROM THE SAME ORGANS

Wesenberg

Tönder

1980

Acta Pathologica Microbiologica Scandinavica Section C Immunolo

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Pathophysiological aspects of immune complex diseases

Sedlacek

1980

Klin Wochenschr

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Immune complexes (IC) may be pathophysiologically active in correlation with the nature and size of the antigen, the type and the quality of the antibody, and the concentration of both. Those parameters are decisive for the composition and the lattice structure of IC. Pathogenic effects are induced: by complement activation and generation of biologically active C' split products via the classical and the alternative pathway, by interaction with Fc and complement receptors resulting in exocytosis of lysosomal contents including degradative enzymes, cationic proteins, vasoactive amines and mediators effective on lymphocytes and macrophages; by direct and indirect activation of the Hageman factor followed by stimulation of the kinin, coagulation and fibrinolysis system; and by modulation of the immune response via the afferent and the efferent branch. All those mechanisms seen to be involved in the induction of lesions along the vessel wall in the various privileged organs.

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Pathophysiological aspects of immune complex diseases

1980

Klin Wochenschr

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Elimination of IC by the phagocytic system occurs mainly by macrophages and contrarotates to the pathogenic effect. Decisive to prevent systemic IC disease is the capacity of the phagocytic system. In the case of its saturation, the danger of the occurrence of IC disease is greatly enhanced. Conclusive evidence seems to exist that IC of extremely small or extremely high lattice structure (precipitates) are less pathogenic than soluble IC of medium network. Small IC in extreme antigen and antibody excess or precipitates exhibit a reduced complement activating potency. Small IC in extreme antigen or antibody excess hardly interact in vitro with membrane receptors and do not induce IC disease when injected or formed in vivo. Highly lattices IC, especially precipitates, are eliminated extremely quickly from the circulation, mainly by macrophages and there deposition in the kidney is significantly reduced. Thus, lack of quality of the antibody to precipitate the antigen and a reduced capacity and effectivity of the phagocytic system to eliminate the IC may be extremely important in the generation of IC diseases. Facing the overwhelming and partly even inconsistant data of this topic, one may doubt whether IC diseases may be regarded to be a defined and coherent disease. Too many variables and questions exist concerning the nature of the antigen, especially in tumor and autoimmune diseases, concerning the quality of the antibody and the characteristics of the pathogenic IC and concerning localization and the elimination process. Nevertheless, common pathophysiological pathways of IC diseases may be recognized.

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Fcσ RECEPTORS AND IgG ASSOCIATED WITH HUMAN MALIGNANT TUMOURS

Cited by 6 publications

References 12 publications

IgG AND OTHER PROTEINS ASSOCIATED WITH HUMAN CARCINOMAS AND CANCER‐FREE TISSUE FROM THE SAME ORGANS

IgG AND OTHER PROTEINS ASSOCIATED WITH HUMAN CARCINOMAS AND CANCER‐FREE TISSUE FROM THE SAME ORGANS

Pathophysiological aspects of immune complex diseases

Pathophysiological aspects of immune complex diseases

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