FDG uptake in brown adipose tissue—A brief report on brown fat with FDG uptake mechanisms and quantitative analysis using dual-time-point FDG PET/CT

Anxiety in Cancer Patients during18F-FDG PET/CT Low Dose: A Comparison of Anxiety Levels before and after Imaging Studies

“…Patients with hearing problems and difficulty in speaking may experience higher levels of anxiety because of the limited communication between them and health professionals [5, 6] (i.e., nurses, technologists of nuclear medicine, and physicians). High levels of anxiety can result in a poor image quality due to patient movement during procedure, which increases the uptake in the brown adipose tissue and in the muscle, leading to image false-positives [5, 7–9]. For that reason, the patient must rest after the injection of the radiopharmaceutical allowing the muscles to relax [9].…”

“…High levels of anxiety can result in a poor image quality due to patient movement during procedure, which increases the uptake in the brown adipose tissue and in the muscle, leading to image false-positives [5, 7–9]. For that reason, the patient must rest after the injection of the radiopharmaceutical allowing the muscles to relax [9]. …”

Review Analysis of the Association between the Prevalence of Activated Brown Adipose Tissue and Outdoor Temperature

“…Of the remaining 33 studies, 25 were considered ineligible after the full article was reviewed (Figure 2). Eight studies fulfilled all of the inclusion criteria (Table 1) [8–15]. Seven had been done in North America and Europe, and 1 in Turkey.…”

“…We found that the prevalence of 18 F-FDG PET-detected activated BAT was very low and varied considerably from 1.72% (for our patients living in a tropical climate) to 6.85% (for the other 8 cohorts in the reviewed literature) [8–15]. In the review analysis over a wide range of outdoor temperature, a simple linear regression analysis of all 9 cohorts showed a significant negative correlation between the prevalence of activated BAT and the average outdoor temperature during the study period.…”

Incidental uptake of 123I MIBG in brown fat

“…The literature mentions that most of these incidental findings are observed when 18 F-FDG is used as the tracer. 1 Few cases of the uptake of 123 I MIBG in brown fat as a possible cause of false positives have been described. 2 On histological comparison of brown fat with the remaining adipose tissue, the former is characterized by containing small, multiloculated cells with a large number of mitochondria, an increase in vascularization and abundant noradrenergic sympathetic innervation.…”