A novel colorimetric and off-on fluorescent chemosensor which contained a strong electron-withdrawing group was synthesized. As expected, the chemosensor exhibited high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Fe 3? (H (CH 3 OH, H 2 O) = 3/7, 1 mM Tris-HCl buffer, pH = 7.40). Upon addition of Fe 3? , the solution of the chemosensor resulted in a color change from colorless to obvious pink. These significant changes in color could be used for naked-eye detection. Furthermore, fluorescence imaging experiments of Fe 3? ions in living MGC-803 cells demonstrated its value of practical applications in biological systems.
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