Feasibility and efficacy of microwave ablation for treating breast fibroadenoma

Abstract

Background: To investigate the safety, efficacy, and follow-up outcomes of microwave ablation (MWA) in patients with breast fibroadenoma. Methods: An institutional review board-approved this study of patients treated with MWA for breast fibroadenoma from October 2017 to March 2019. Clinical features of patients and breast fibroadenoma were analyzed. At follow-up all patients received physical examination and ultrasound imaging. Results: In total, 171 patients with 271 lesions were enrolled. The mean lesion diameter was 1.35 ± 0.47 cm. The results revealed differential lesion states, including stability, enlargement, reduction, and complete regression, at 1-6, 6-12, and >12 months of follow-up. The size was reduced in 22.14% (31/140), 26.36% (29/110), and 36.36% (16/44) of the lesions at 1-6, 6-12, and >12 months of followup, respectively. The proportion of lesions with complete regression was 24.29% (34/140) at 1-6 months, 45.45% (50/110) at 6-12 months, and 40.91% (18/44) at >12 months of follow up. There was no significant relationship between the curative effect and age, lesion location, and blood flow in patients with breast fibroadenoma after MWA (p > .05), but there was statistically significant relationship with lesion diameter (categorized as <1.5 cm and !1.5 cm) (p < .05). Conclusions: The current evidence indicates that MWA is a safe and effective method for treating breast fibroadenoma. Nevertheless, further large-scale prospective trials and well-designed future studies are warranted to validate our findings.

Determining of Ablation Zone in Ex Vivo Bovine Liver Using Time-Shift Measurements

“…One other potential source of error that could lead to discrepancies between the measured and calculated radius is the bad coupling of the applicator to the liver tissue during an ablation. For instance, if an air bubble forms during ablation [25][26][27], it can change the layers of the transmission medium that the transmitted signal must traverse. In such a scenario, erroneous ∆t measurements may result.…”

Efficacy and safety of microwave ablation for benign breast lesions: a systematic review and meta-analysis.

“…It is generally believed that it requires removal when the lesion volume is greater than 2 cm [2]. Small asymptomatic breast lesions generally tend to be treated with conservative management with regular follow-up, which should be accompanied by auxiliary examination (i.e., ultrasound and/or mammography) every 3-6 months [3]. How-ever, many BBLs need to be excised due to obvious symptoms, progressive enlargement, and potential canceration [2].…”