“…40 Of studies that compared telediagnosis to only FTF diagnosis, using kappa statistics, the overall diagnostic agreement between teledermatologists and FTF dermatologists showed high variability, from fair (kappa 0.35) 36 to almost perfect (kappa 0.91), 46 even though the majority of them (eight studies from 10) achieved substantial to almost perfect agreement. 5,38,41,42,[44][45][46]48,50 The agreement of management or therapy plan between both groups was only assessed by two studies, varying from moderate (kappa 0.57) 45 to almost perfect (kappa 0.86). 46 The intra-observer diagnostic reliability was investigated by three studies (kappa ranged from 0.49 to 0.69), 36,38,42 and the intra-observer management reliability by only one of them (kappa 0.58).…”