Feasibility and reproducibility of ShearWave<sup>TM</sup>
 elastography of fetal baboon organs

Quarello, E.; Lacoste, Romain; Mancini, Julien; Melot-Dusseau, Sandrine; Gorincour, Guillaume

doi:10.1002/pd.4655

Cited by 13 publications

(9 citation statements)

References 33 publications

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“…These methods generate a considerably higher thermal index (TI) than a conventional US examination does. For that reason, some authors have studied SWE™ on animals (pregnant baboons) rather than pregnant women [ 23 , 42 ]. Although the early data appear reassuring, it is currently too early to generalize the use of these techniques on pregnant women and their fetuses.…”

Section: Introductionmentioning

confidence: 99%

Measurement of shear wave speed dispersion in the placenta by transient elastography: A preliminary ex vivo study

Simon¹,

Callé²,

Perrotin³

et al. 2018

PLoS ONE

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BackgroundPlacental elasticity may be modified in women with placental insufficiency. Shear wave elastography (SWE) can measure this, using acoustic radiation force, but the safety of its use in pregnant women has not yet been demonstrated. Transient elastography (TE) is a safer alternative, but has not yet been applied to the placenta. Moreover, the dispersion of shear wave speed (SWS) as a function of frequency has received relatively little study for placental tissue, although it might improve the accuracy of biomechanical assessment.ObjectiveTo explore the feasibility and reproducibility of TE for placental analysis, to compare the values of SWS and Young’s modulus (YM) from TE and SWE, and to analyze SWS dispersion as a function of frequency ex vivo in normal placentas.Materials and methodsTen normal placentas were analyzed ex vivo by an Aixplorer ultrasound system as shear waves were generated by a vibrating plate and by using an Aixplorer system.The frequency analysis provided the value of the exponent n from a fractional rheological model applied to the TE method. We calculated intra- and interobserver agreement for SWS and YM with 95% prediction intervals, created Bland-Altman plots with 95% limits of agreement, and estimated the intraclass correlation coefficient (ICC).Main resultsThe mean SWS was 1.80 m/s +/- 0.28 (standard deviation) with the TE method at 50 Hz and 1.82 m/s +/-0.13 with SWE (P = 0.912). No differences were observed between the central and peripheral regions of placentas with either TE or SWE. With TE, the intraobserver ICC for SWS was 0.68 (0.50–0.82), and the interobserver ICC for SWS 0.65 (0.37–0.85). The mean parameter n obtained from the fractional rheological model was 1.21 +/- 0.12, with variable values of n for any given SWS.ConclusionsTE is feasible and reproducible on placentas ex vivo. The frequency analysis of SWS provides additional information about placental elasticity and appears to be able to distinguish differences between placental structures.

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Section: Introductionmentioning

confidence: 99%

Measurement of shear wave speed dispersion in the placenta by transient elastography: A preliminary ex vivo study

Simon¹,

Callé²,

Perrotin³

et al. 2018

PLoS ONE

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“…Data on intrauterine elastographic evaluation of foetal tissues are very limited, with a few studies available in the literature using baboon foetuses as an experimental model (Quarello, Lacoste, Mancini, Melot‐Dusseau, & Gorincour, ,b; Quarello et al., ) and a single study evaluating human foetuses (Zheng, Wu, & Tan, ). These studies demonstrated the feasibility, reproducibility and applicability of elastography in the evaluation of maternal and foetal tissues, revealed important information about normal elasticity standards, however, have shown only weak correlation between elastography variables and gestational development.…”

Section: Introductionmentioning

confidence: 99%

Acoustic radiation force impulse (ARFI) elastography to asses maternal and foetal structures in pregnant ewes

Silva

Uscátegui

Santos

et al. 2018

Reprod Domestic Animals

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Contents The aim of this study was to evaluate the stiffness of foetal lungs, liver, kidneys and placentomes by acoustic radiation force impulse (ARFI) elastography in ovine and to correlate obtained findings with foetal development. Twenty‐four ewes were included, and tissue stiffness of foetal lung, liver, kidney and placentome was measured beginning with 10th gestational week by qualitative–quantitative ARFI elastography. A total of 33 healthy lambs were born. Qualitative elastographic analysis permitted to classify maternal and foetal tissues elasticity in decreasing order as follows: placentome, kidney, liver and lung. Regarding quantitative ARFI elastography data, shear wave velocity (SWV) of foetal lung and liver varied. The lung SWV decreased gradually from the 16th to the 21st gestational week (R2 = 0.80; p < 0.001), while liver SWV increased gradually from the 14th to 21st gestational week (R2 = 0.80; p < 0.001). In contrast, the kidneys and placentomes SWV's remained constant through gestation (p = 0.076; and 0.34). ARFI elastography was shown feasible for evaluation of maternal and foetal tissues stiffness in the ovine model. It can be used to demonstrate pulmonary and hepatic stiffness modifications during foetal development.

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“…It is, however, important to acknowledge that the present results could have been affected by peristaltic movements occurring in pregnant bitches, variability in foetal organ depth, foetal movements, acoustic shadowing generated by foetal ribs, and the proportions of areas of interest evaluated. These limitations of both imaging techniques have previously been described by Quarello et al (2015) and may impinge on the detection of relationships between echotextural and elastographic characteristics of foetal lungs and livers.…”

Section: Discussionmentioning

confidence: 99%

Elastographic and echotextural characteristics of foetal lungs and liver during the final 5 days of intrauterine development in dogs

Simões

Feliciano

Maronezi

et al. 2018

Animal Reproduction Science

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Objective was to evaluate the echotexture and characteristics during terminal development of canine foetal respiratory and hepatic systems through elastographic examinations. Fifteen pregnant bitches were evaluated by ultrasonography twice daily, from the 53rd gestational day until whelping, and images obtained from 120 to 0 h before parturition were analysed. Images of foetal lungs and liver were recorded and then used for computer-assisted analyses to determine quantitative attributes. Acoustic Radiation Force Impulse (ARFI) elastographic of internal organs were classified as 'soft' (white areas) or 'hard' (dark areas) and quantitative analyses determined the mean shear wave velocities (SWV) of foetal lungs and liver. After delivery, canine neonates were clinically evaluated, and their health status was monitored weekly until 60 days post-partum. Sonographic parameters over time were compared by ANOVA and Pearson's correlations were used to determine associations between SWVs and echotextural variables. Foetal lungs and liver had a homogeneous echotexture and pulmonary parenchyma appeared hyperechoic when compared with that of the liver. Mean numerical pixel values (NPVs) of lungs decreased from 120 to 24 h and subsequently increased until parturition (P = 0.04). Lungs and liver mean (± SD) SWVs (0.98 ± 0.12 and 0.84 ± 0.11 m/s, respectively) didn't vary (P > 0.05) over time. Fluctuations in pulmonary NPVs indicated there was a pattern corresponding to structural and functional changes that occur during the terminal stage of pre-natal canine development and hence can be a useful diagnostic tool in veterinary. Foetal lung and liver SWVs were relatively consistent and there was no detectable changes during the pre-partum period for this variable or in echotexture.

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Feasibility and reproducibility of ShearWave^TM elastography of fetal baboon organs

Abstract: Transabdominal ShearWave(TM) Elastography of fetal organs can be achieved in pregnant baboons. The intra-observer and inter-observer reproducibility is correct but vary according to the targeted organs.

Cited by 13 publications

References 33 publications

Measurement of shear wave speed dispersion in the placenta by transient elastography: A preliminary ex vivo study

Measurement of shear wave speed dispersion in the placenta by transient elastography: A preliminary ex vivo study

Acoustic radiation force impulse (ARFI) elastography to asses maternal and foetal structures in pregnant ewes

Elastographic and echotextural characteristics of foetal lungs and liver during the final 5 days of intrauterine development in dogs

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Feasibility and reproducibility of ShearWaveTM elastography of fetal baboon organs

Abstract: Transabdominal ShearWave(TM) Elastography of fetal organs can be achieved in pregnant baboons. The intra-observer and inter-observer reproducibility is correct but vary according to the targeted organs.

Cited by 13 publications

References 33 publications

Measurement of shear wave speed dispersion in the placenta by transient elastography: A preliminary ex vivo study

Measurement of shear wave speed dispersion in the placenta by transient elastography: A preliminary ex vivo study

Acoustic radiation force impulse (ARFI) elastography to asses maternal and foetal structures in pregnant ewes

Elastographic and echotextural characteristics of foetal lungs and liver during the final 5 days of intrauterine development in dogs

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Feasibility and reproducibility of ShearWave^TM elastography of fetal baboon organs