We would like to congratulate the authors for a comprehensive periprocedural ultrasound-based study 1 of radial arteries to help understand the pathophysiology of radial arterial injuries and occlusion after transradial procedures.There are, however, a few limitations of this work that may have confounded the outcomes and conclusions of the study, which we would like to highlight.The authors found radial artery occlusion (RAO) in 3.4% of all cases at 3 hours postprocedure and 3.9% on a 30-day follow-up, which is higher compared with previous ultrasound-based studies.
2In this article, RAO was associated with the presence of multiple punctures, but they had no relationship with smaller arterial size, 1 a term for which authors do not offer a clear definition. Furthermore, there was a lack of data in the article on the distribution of various radial artery diameters in patients requiring >1 puncture attempts (16.1%) or in patients developing RAO on follow-up. This information is relevant because radial arteries with smaller diameters often require multiple puncture attempts, facing greater intimal insult, and have hence been found to have higher postprocedure occlusions.
2,3A lack of correlation between small radial arteries and RAO in this study 1 may also have been on account of a limited number of patients with smaller radial arteries, although these data are unavailable.In addition, 56.7% of the patient cohort underwent a coronary angiogram and received 2500 IU of unfractionated heparin. Higher doses of heparin have been shown to reduce RAO compared with lower doses 2 without a risk of increased bleeding. Thus, lower heparin dosing could have influenced rates of RAO on follow-up, especially in situations where there was greater intimal insult in the setting of multiple punctures.The use of a prolonged nonocclusive compression protocol (3 hours in the study) may have had a negative influence on overall RAO occurrence because shorter compression times have been shown to significantly reduce rates of access artery occlusions.
2The study's conclusion about correlation of multiple punctures with RAO may have been more relevant if the 2 confounding variables of heparinization and compression time had also been used optimally, in keeping with current practice, and based on recent data.
2Although this is a insightful study, 1 further exploration into various anatomic and procedural correlates of RAO, including the reported benefits of accessing the largest and straightest forearm artery based on ultrasound, 4 needs to be further validated in large randomized settings.
DisclosuresNone.
Yashasvi Chugh, MDInternal