Feasibility of a group-based laughter yoga intervention as an adjunctive treatment for residual symptoms of depression, anxiety and stress in people with depression

Bressington, Daniel; Mui, Jolene; Yu, C.W.; Leung, Sau Fong; Cheung, Kin; Wu, Cynthia Sau Ting; Bollard, Martin; Chien, Wai Tong

doi:10.1016/j.jad.2019.01.030

Cited by 50 publications

(37 citation statements)

References 38 publications

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“…According to the world health organization (WHO), around 350 million people suffer from depression to some degree and it is expected to become the world's leading disease burden by 2030 (3). Studies on sequential treatment of depression show that residual symptoms, such as depressed mood, impaired function and negative concept, still exist in patients with complete remission after treatment (4), and patients with residual symptoms have a higher recurrence rate and a shorter recurrence interval (5).…”

Section: Introductionmentioning

confidence: 99%

Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice

Qiao¹,

Zhao²,

Zhang³

et al. 2020

Ann Transl Med

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Background: Mental stress mainly induces depression, and predictable stress, as well as a constant bombardment of chronic unpredictable micro-stressors, always coexist in daily life. However, the combined effect of predictable and unpredictable stress on depression is still not fully understood. Methods:The chronic restraint stress (CRS) is to restrain the mice for 6 h per day for 3 weeks, and the chronic unpredictable mild stress (CUMS) is to stimulate the mice with 7 different stressors for 3 weeks. We evaluated the combined effect of CRS and CUMS on depression-like symptoms using behavioral tests and investigated the action mechanism through analysis of neurotransmitters, brain-derived factors, inflammatory factors, antioxidants, and intestinal microorganisms.Results: Our data suggested the combined stress of CRS and CUMS caused significant weight loss, food intake reduction, depression-like behaviors-including anhedonia, learned helplessness, and reduction in spontaneous activity-and even atrophy and severe structural damage to the hippocampus in mice. Our pathogenesis study showed that combined stress-induced the reduction of glucocorticoid receptor (GR) levels, loss of oligodendrocytes (NG2 and Olig2 cells), and inhibition of neuron proliferation in the CA1, CA3, and DG regions of the hippocampus, decreased the contents of monoamine neurotransmitters (5-HT and NE) and BDNF in the cerebral cortex, caused hyperactivity of the HPA system, led to immune dysfunction, aggravated oxidative stress, and weakened the capacity of antioxidants in mice. Compared with single stress, combined stress gave rise to a more significant diversity change of the gut microbiota.Conclusions: Combined stress caused significant depression-like behaviors, atrophy, and severe structural damage to the hippocampus in mice via monoamine neurotransmitter, BDNF, HPA axis, neurogenesis, and neurodegenerative, immune, oxidative stress and gut-brain axis action pathways.

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Section: Introductionmentioning

confidence: 99%

Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice

Qiao¹,

Zhao²,

Zhang³

et al. 2020

Ann Transl Med

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“…Our study provides stronger evidence than previous smaller hemodialysis noncontrolled studies 27,33,34 supporting an association between laughter therapy and an improvement in patient‐reported depressive symptoms and mood. Previous randomized studies in people with depression showed similar improvements in depression using the Depression Anxiety Scale Stress Score 45 and the Geriatric Depression Scale 32 . A noncontrolled healthy sample also described the reduced anxiety effects of laughter, as measured by the Profile of Mood States‐Brief Japanese Version 46 …”

Section: Discussionmentioning

confidence: 71%

The effects of laughter therapy on depression symptoms in patients undergoing center hemodialysis: A pragmatic randomized controlled trial

Bennett

Hussein

Reiterman

et al. 2020

Hemodialysis International

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Introduction: People with end-stage renal disease undergoing hemodialysis are at increased risk for stress, anxiety, and depression. The study objective was to measure the effect of intradialytic group laughter therapy on depressive symptoms in people on hemodialysis (HD). Methods: Pragmatic randomized controlled trial conducted with prevalent HD patients in 10 centers in Northern California. The intervention group received a once weekly, 30-minute group laughter therapy session for 8 weeks. Primary outcome was the number of people with depressive symptoms as measured using the four Item Patient Health Questionnaire. Secondary outcomes were anxiety, subjective well-being, and patient-reported outcome measures. Findings: In all, 151 participants completed both predepression and postdepression symptom measures (72 intervention and 79 control). The proportion of patients with self-reported depressive symptoms changed from 17 (22%) to 16 (20%), in the control and from 11 (17%) to 5 (8%) in the intervention arms, respectively (P = 0.04). In the control arm, 7 out of the 17 patients with selfreported depressive symptoms at baseline continued to report depressive symptoms at follow up compared to the intervention arm where only 1 of 12 patients continued to report depressive symptoms. No differences were noted between the groups for reported anxiety, patient-reported dialysis symptoms, and subjective well-being. Discussion: This study found intradialytic group laughter can decrease the number of people with depressive symptoms receiving hemodialysis. Larger and long-term studies are required to evaluate the effect of intradialytic laughter on patient related outcomes and quality of life.

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“…In addition to the improvement of depression, yoga interventions promote mental health and quality of life and interrupt negative thinking in patients with depression[ 168 , 169 ]. A meta-analysis of 10 studies has shown that yoga practices have a statistically significant effect as an adjunct treatment in patients with MDD[ 162 ].…”

Section: The Clinical Effect Of Yogamentioning

confidence: 99%

Therapeutic role of yoga in neuropsychological disorders

Nourollahimoghadam¹,

Gorji²,

Gorji³

et al. 2021

WJP

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Yoga is considered a widely-used approach for health conservation and can be adopted as a treatment modality for a plethora of medical conditions, including neurological and psychological disorders. Hence, we reviewed relevant articles entailing various neurological and psychological disorders and gathered data on how yoga exerts positive impacts on patients with a diverse range of disorders, including its modulatory effects on brain bioelectrical activities, neurotransmitters, and synaptic plasticity. The role of yoga practice as an element of the treatment of several neuropsychological diseases was evaluated based on these findings.

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Feasibility of a group-based laughter yoga intervention as an adjunctive treatment for residual symptoms of depression, anxiety and stress in people with depression

Cited by 50 publications

References 38 publications

Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice

Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice

The effects of laughter therapy on depression symptoms in patients undergoing center hemodialysis: A pragmatic randomized controlled trial

Therapeutic role of yoga in neuropsychological disorders

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