Feasibility of breast conservation surgery in locally advanced breast cancer downstaged by neoadjuvant chemotherapy: A study in mastectomy specimens using simulation lumpectomy

Viswambharan, Jaiganesh L.K.; Dharanipragada, Kadambari; Iyengar, Krishnan R; Srinivasan, Krishnamachari

doi:10.4103/0019-509x.15097

Cited by 12 publications

(17 citation statements)

References 17 publications

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“…Our figure is also comparable with that reported by Viswambharan et al [12] where the size of the primary tumour ranged from 5-9 cm (mean = 7.1 cm). The mean post-chemotherapy tumour size in our study, was 3.9 ± 1.3 cm which was comparable to figures reported by Chen et al [15] (2.2 to 3.2 cm) and Viswambharan et al [12] (3.8 cm).…”

Section: Discussionsupporting

confidence: 92%

“…This figure of response is within the range of the reported studies where Newman et al [10] found that 75% of patients were feasible to BCS. The overall objective response of the primary tumour in patients with locally advanced breast cancer ranged from 71% to 87% [11,12]. On the other hand, our results are much higher than that reported by Yadav et al [13] who found that only 23% of patients with locally advanced breast cancer were candidates for BCS after neoadjuvant chemotherapy.…”

Section: Discussioncontrasting

confidence: 53%

See 1 more Smart Citation

Feasibility of breast conservation after neoadjuvant taxene based chemotherapy in locally advanced breast cancer: a Prospective Phase I trial

et al. 2010

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 53%

Feasibility of breast conservation after neoadjuvant taxene based chemotherapy in locally advanced breast cancer: a Prospective Phase I trial

et al. 2010

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“…Several other studies have shown a similar overall objective response of the primary tumor in patients with locally advanced breast cancer ranging from 71 to 87 %. 7,8,9 On the other hand, the present results are much higher than that reported by Yadav et al who found that only 23 % showed response to neoadjuvant chemotherapy. 10 Another study by Tamer et al in 2010 also showed much lesser overall response rates to neoadjuvant chemotherapy 54.5 %(CR 3% and PR 51.5%) and Kim et al also reported that the overall response rate to neoadjuvant chemotherapy is 60 %(CR 4 % and PR 56%) respectively.…”

Section: Discussioncontrasting

confidence: 56%

A study on role of neo adjuvant chemotherapy in locally advanced non-metastatic breast cancer

Siddhartha

Kanchana

2018

Int Surg J

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Background: Nearly 1.7 million new breast cancer cases were diagnosed worldwide in 2012.Breast cancer is the second most common cancer in women worldwide. Globally, breast cancer now represents one in four of all cancers in women. breast cancer has ranked number one cancer among Indian females with age adjusted rate as high as 25.8 per 100,00 women and mortality 12.7 per 100,000 women. Around 90,000 new cases of breast cancer are diagnosed every year in India and majority present as Locally Advanced Breast Cancer (LABC). Neo adjuvant chemotherapy is a commonly used modality for LABC, that gives an upfront systemic therapy in high risk patients with expected micro metastatic burden and also helps in down staging the disease and offering radical cure.Methods: All Locally Advanced Non-Metastatic Breast Carcinoma (T3 N0, T3 N1, T4a, T4b, T4c, Any N2/N3, MO patients who received Neo Adjuvant Chemotherapy and underwent surgery were included. All these patients received 5-Fluorouracil, Adriamycin and Cyclophosphamide (FAC) regime, following therapy patients were offered either Modified Radical Mastectomy or Breast Conservative Surgery with axillary node dissection and Radiotherapy.Results: Complete response was achieved in 20 (66.6%) patients,3 (10%) of the patients had partial response and 7 (23.3%) progressed clinically.Conclusions: Neo adjuvant chemotherapy helped to study response of tumour size to NAC, down stage disease and to convert inoperable cases to resectability.

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“…This result translates into a successful effect of preoperative chemotherapy in this study compared with other studies in Westernized countries. A few studies have been reported on BCS after preoperative chemotherapy for Asian patients [20,21]. However, in these studies, relatively small numbers of patients (30 patients) were enrolled compared with our study (204 patients).…”

Section: Discussionmentioning

confidence: 85%

Locoregional Recurrence of Breast Conserving Surgery after Preoperative Chemotherapy in Korean Women with Locally Advanced Breast Cancer

et al. 2011

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PurposePreoperative chemotherapy has been used to increase the rate of breast conserving surgery (BCS) in Caucasian women. However, whether it would also increase the rate of BCS in Korean women has not been verified. The aim of this study was to determine the effectiveness of preoperative chemotherapy to make BCS possible in Korean women who have locally advanced cancer without any increase of locoregional recurrence according to operation methods (BCS vs. mastectomy).MethodsFrom August 2002 to April 2005, 205 patients with stage II or III breast cancer were enrolled in a phase III randomized trial of preoperative chemotherapy. Surgeons decided on the type of surgery (mastectomy or BCS) at initial diagnosis. By randomization, patients received four cycles of either docetaxel/capecitabine or doxorubicin/cyclophosphamide followed by surgery and crossover to the other treatment as postoperative chemotherapy.ResultsThe mean tumor size was 3.29 cm and the mean breast volume was 489 cc at diagnosis. After preoperative chemotherapy, clinical response was shown in 76.0% of the patients. Of the 71 patients planned for a mastectomy at initial diagnosis, 27 patients underwent BCS (38.0%). Clinical T stage after preoperative chemotherapy, pathologic T size and lymphatic invasion were correlated with conversion to BCS. In multivariate analysis, only lymphatic invasion showed statistical significance. Locoregional disease-free survival did not statistically differ between the two operation methods for the patients who were planned for a mastectomy at the initial exam.ConclusionThis study showed that preoperative chemotherapy also increased the rate of BCS, while avoiding any increase of locoregional recurrence in Korean women with locally advanced breast cancer.

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Feasibility of breast conservation surgery in locally advanced breast cancer downstaged by neoadjuvant chemotherapy: A study in mastectomy specimens using simulation lumpectomy

Abstract: BACKGROUND:The response of locally advanced breast cancer (LABC) to neoadjuvant chemotherapy (NACT)

Cited by 12 publications

References 17 publications

Feasibility of breast conservation after neoadjuvant taxene based chemotherapy in locally advanced breast cancer: a Prospective Phase I trial

Feasibility of breast conservation after neoadjuvant taxene based chemotherapy in locally advanced breast cancer: a Prospective Phase I trial

A study on role of neo adjuvant chemotherapy in locally advanced non-metastatic breast cancer

Locoregional Recurrence of Breast Conserving Surgery after Preoperative Chemotherapy in Korean Women with Locally Advanced Breast Cancer

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