Feasibility of carbon ion radiotherapy for locally advanced sinonasal adenocarcinoma

Koto, Masashi; Hasegawa, Azusa; Takagi, Ryo; Sasahara, Go; Ikawa, Hiroaki; Mizoe, Jun Etsu; Jingu, Keiichi; Tsujii, Hirohiko; Kamada, Tadashi; Okamoto, Yoshitaka

doi:10.1016/j.radonc.2014.09.009

Cited by 35 publications

(36 citation statements)

References 18 publications

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“…This value is higher than our estimated value of 65% in photon therapy. Our results are comparable to previous studies of carbon‐ion radiotherapy at NIRS . In a phase II study, Mizoe et al .…”

Section: Discussionsupporting

confidence: 91%

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Prospective observational study of carbon‐ion radiotherapy for non‐squamous cell carcinoma of the head and neck

et al. 2017

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To evaluate the efficacy and safety of carbon‐ion radiotherapy for non‐squamous cell carcinoma of the head and neck, 35 patients were enrolled in this prospective study. The primary end‐point was the 3‐year local control rate, and the secondary end‐points included the 3‐year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow‐up time for all patients was 39 months. Thirty‐two and three patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was dominant (60%). Four patients had local recurrence and five patients died. The 3‐year local control and overall survival rates were 93% and 88%, respectively. Acute grade 2–3 radiation mucositis (65%) and dermatitis (31%) was common, which improved immediately with conservative therapy. Late mucositis of grade 2, grade 3, and grade 4 were observed in 11, one, and no patients, respectively. There were no adverse events of grade 5. Carbon‐ion radiotherapy achieved excellent local control and overall survival rates for non‐squamous cell carcinoma. However, the late mucosal adverse events were not rare, and meticulous treatment planning is required. Trial registration no. UMIN000007886.

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Section: Discussionsupporting

confidence: 91%

“…reported that the 5‐year local control rate was 73% for adenoid cystic carcinoma. A retrospective study of 22 patients with adenocarcinoma showed a 3‐year local control rate of 84% . Recently, Jensen et al .…”

Section: Discussionmentioning

confidence: 99%

Prospective observational study of carbon‐ion radiotherapy for non‐squamous cell carcinoma of the head and neck

et al. 2017

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“…The prospective phase II COSMIC trial which evaluated combination IMRT and CIRT for incompletely resected and inoperable adenoid cystic and other malignant salivary gland tumors showed 82% local control and 78% overall survival at 3 years with acceptable toxicity [125]. Likewise, CIRT results have been published for locally advanced squamous cell carcinoma of the ear [126], lacrimal gland carcinoma [127], mucosal malignant melanoma [128], sinonasal adenocarcinoma [129] and base of tongue adenoid cystic carcinoma [130]. …”

Section: Clinical Experiences With Cirtmentioning

confidence: 99%

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Mohamad

Sishc

Saha

et al. 2017

Cancers

148

130

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Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and a higher relative biological effectiveness (RBE). This enhanced RBE is driven by a unique DNA damage signature characterized by clustered lesions that overwhelm the DNA repair capacity of malignant cells. These physical and radiobiological characteristics imbue heavy ions with potent tumoricidal capacity, while having the potential for simultaneously maximally sparing normal tissues. Thus, CIRT could potentially be used to treat some of the most difficult to treat tumors, including those that are hypoxic, radio-resistant, or deep-seated. Clinical data, mostly from Japan and Germany, are promising, with favorable oncologic outcomes and acceptable toxicity. In this manuscript, we review the physical and biological rationales for CIRT, with an emphasis on DNA damage and repair, as well as providing a comprehensive overview of the translational and clinical data using CIRT.

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“…The improved dose distribution can potentially be exploited either by allowing higher radiation doses to the tumor with less radiation‐induced normal tissue toxicity or by reducing adverse effects at equivalent effective doses. For cancers in the head and neck region, carbon ion radiotherapy (C‐ion RT) is mainly performed for radioresistant tumors, such as salivary gland carcinoma and mucosal malignant melanoma, and it has shown promising results for locally advanced head and neck cancer …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base

Koto¹,

Hasegawa²,

Takagi³

et al. 2016

Head & Neck

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Feasibility of carbon ion radiotherapy for locally advanced sinonasal adenocarcinoma

Cited by 35 publications

References 18 publications

Prospective observational study of carbon‐ion radiotherapy for non‐squamous cell carcinoma of the head and neck

Prospective observational study of carbon‐ion radiotherapy for non‐squamous cell carcinoma of the head and neck

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base

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