Printing wastewater is generally considered as hazardous waste whose treatment and disposal are strictly regulated. Although electro-coagulation (EC) process has been successfully applied for the treatment of different types of wastewater, its application for printing wastewater is rarely reported. In this study, EC was applied to treat the printing ink wastewater, taken from a paper packing factory in An Giang Plant Protection Join Stock Company, which was highly colored and contaminated with organic compounds. The treatment process was performed using aluminum electrodes for two hours. Effects of applied voltage (5 -40 V), pH (5 -9), electrodes distance (1 -5 cm), salt concentration in electrolyte solution (0.05 -0.4 g/L), and the rotational speed of stirring (0 -400 rpm) on the removal efficiencies of color and COD were investigated. Based on the effects of various factors, optimum condition for the treatment was given. Results showed that the EC process can effectively remove color and COD for 30 min. The effluent quality in terms of color and COD met well National Technical Regulation on Industrial Wastewater (QCVN 40-2011/BTNMT, column B). Finally, a comparison in removal efficiencies between the processes of EC and chemical-coagulation was also presented.