Feasibility of FAIR imaging for evaluating tumor perfusion

Cho, Jee-Hyun; Cho, Gyunggoo; Song, Young Duk; Lee, Chulhyun; Park, Bumwoo; Lee, Chang Kyung; Kim, Namkug; Park, Sung Bin; Kang, Jong Soon; Kang, Moo Rim; Kim, Hwan Mook; Kim, Young Ro; Cho, Kyoung‐Sik; Kim, Jeong Kon

doi:10.1002/jmri.22298

Cited by 9 publications

(12 citation statements)

References 20 publications

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“…In our study, the mean HBFI was approximately 8 times higher and blood flow in HCC was approximately 10 times higher than the blood flow of the erector spinae muscle, which is consistent to a recent study comparing tumor perfusion to perfusion of the psoas muscle in an animal model (32). Moreover, we observed slight differences in the intrahepatic blood flow between left and right liver lobes as well as a higher mean SBFI compared with the mean HBFI, which is also consistent with recent literature (33, 34).…”

Section: Discussionsupporting

confidence: 92%

Feasibility of semiquantitative liver perfusion assessment by ferucarbotran bolus injection in double‐contrast hepatic MRI

Fischer¹,

Donati²,

Reiner³

et al. 2012

Magnetic Resonance Imaging

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Purpose: To evaluate the feasibility of semiquantitative measurement of liver perfusion from analysis of ferucarbotran induced signal-dynamics in double-contrast liver MR-imaging (DC-MRI). Materials and Methods:In total 31 patients (21 men; 58 6 10 years) including 18 patients with biopsy proven liver cirrhosis prospectively underwent clinically indicated DC-MRI at 1.5 Tesla (T) with dynamic T2*-weighted gradientecho imaging after ferucarbotran bolus injection. Breathing artefacts in tissue and input time curves were reduced by Savitzky-Golay-filtering and semiquantitative perfusion maps were calculated using a model free approach. Hepatic blood flow index (HBFI) and splenic blood flow index (SBFI) were determined by normalization of arbitrary perfusion values to the perfusion of the erector spinae muscle resulting in a semiquantitative perfusion measure.Results: In 30 of 31 patients the evaluated protocol could successfully be applied. Mean HBF was 7.7 6 2.46 (range, 4.6-12.8) and mean SBF was 13.20 6 2.57 (range, 8.5-17.8). A significantly lower total HBF was seen in patients with cirrhotic livers as compared to patients with noncirrhotic livers (P < 0.05). In contrast, similar SBF was observed in cirrhotic and noncirrhotic patients (P ¼ 0.11).Conclusion: Capturing the signal dynamics during bolus injection of ferucarbotran in DC-MRI of the liver allows for semiquantitative assessment of hepatic perfusion that may be helpful for a more precise characterisation of liver cirrhosis and focal liver lesions.

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Section: Discussionsupporting

confidence: 92%

Feasibility of semiquantitative liver perfusion assessment by ferucarbotran bolus injection in double‐contrast hepatic MRI

Fischer¹,

Donati²,

Reiner³

et al. 2012

Magnetic Resonance Imaging

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“…Besides artifacts caused by movement, susceptibility difference, magnetic field inhomogeneity and fat near the abdomen, the sensitivity of ASL to low perfusion in tumor makes imaging especially difficult. A study compared ASL and DCE‐MRI in mouse tumor and found high correlation between blood flow and K ep , the rate constant of transfer between the extracellular space and the blood plasma . However, large variability and very high flow (207 ± 111 mL/100 g/min) values were reported in center of tumor.…”

Section: Introductionmentioning

confidence: 99%

Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI

et al. 2014

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Angiogenesis plays a major role in tumor growth and metastasis, with tumor perfusion regarded as a marker for angiogenesis. To evaluate antiangiogenic treatment response in vivo, we investigated arterial spin labeling (ASL) magnetic resonance imaging (MRI) to measure tumor perfusion quantitatively. Chronic and 24-h acute treatment responses to bevacizumab were assessed by ASL and dynamic-contrast-enhanced (DCE) MRI in the A498 xenograft mouse model. After the MRI, tumor vasculature was assessed by CD34 staining. After 39 days of chronic treatment, tumor perfusion decreased to 44.8 ± 16.1 mL/100 g/min (P < 0.05), compared to 92.6 ± 42.9 mL/100 g/min in the control group. In the acute treatment study, tumor perfusion in the treated group decreased from 107.2 ± 32.7 to 73.7 ± 27.8 mL/100 g/min (P < 0.01; two-way analysis of variance), as well as compared with control group post dosing. A significant reduction in vessel density and vessel size was observed after the chronic treatment, while only vessel size was reduced 24 h after acute treatment. The tumor perfusion correlated with vessel size (r = 0.66; P < 0.005) after chronic, but not after acute treatment. The results from DCE-MRI also detected a significant change between treated and control groups in both chronic and acute treatment studies, but not between 0 and 24 h in the acute treatment group. These results indicate that tumor perfusion measured by MRI can detect early vascular responses to antiangiogenic treatment. With its noninvasive and quantitative nature, ASL MRI would be valuable for longitudinal assessment of tumor perfusion and in translation from animal models to human.

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“…The parameter obtained with curve-pattern analysis has a strong correlation with k ep . 16 Because k ep has been shown to be sensitive to treatment in previous literature, 17,18 this finding suggests a similar role for .…”

Section: Discussionmentioning

confidence: 56%

Retinoblastoma: Value of Dynamic Contrast-Enhanced MR Imaging and Correlation with Tumor Angiogenesis

Rodjan¹,

Graaf²,

Valk³

et al. 2012

AJNR Am J Neuroradiol

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Feasibility of FAIR imaging for evaluating tumor perfusion

Cited by 9 publications

References 20 publications

Feasibility of semiquantitative liver perfusion assessment by ferucarbotran bolus injection in double‐contrast hepatic MRI

Feasibility of semiquantitative liver perfusion assessment by ferucarbotran bolus injection in double‐contrast hepatic MRI

Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI

Retinoblastoma: Value of Dynamic Contrast-Enhanced MR Imaging and Correlation with Tumor Angiogenesis

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