Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A Multicenter Study in Spain

Alcolea, Daniel; Martínez-Lage, Pablo; Izagirre, Andrea; Clerigué, Montserrat; Carmona-Iragui, María; Álvarez, Rosa; Fortea, Juan; Balasa, Mircea; Morenas‐Rodríguez, Estrella; Lladó, Albert; Grau, Oriol; Blennow, Kaj; Lleó, Alberto; Molinuevo, José Luís

doi:10.3233/jad-131334

Cited by 56 publications

(75 citation statements)

References 25 publications

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“…Less blood was used for EBP in OUH (median [minimum-maximum], 15 [7][8][9][10][11][12][13][14][15][16][17][18][19][20] mL) than in KUH (18 [15][16][17][18][19][20] mL) and in SCH (19 [18][19][20] mL; P = .014). The time from LP to EBP (P = .7), amount of blood used in EBP (P = .6), or duration of bed rest after EBP (P = .1) had no correlation with EBP efficacy.…”

Section: Resultsmentioning

confidence: 99%

Postdural puncture headache and epidural blood patch use in elderly patients

Sjövall

Kokki

Turunen

et al. 2015

Journal of Clinical Anesthesia

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Section: Resultsmentioning

confidence: 99%

Postdural puncture headache and epidural blood patch use in elderly patients

Sjövall

Kokki

Turunen

et al. 2015

Journal of Clinical Anesthesia

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“…This is a common problem in clinical research, particularly in psychiatry, as well as acupuncture [63]. In future research, a multicenter study [64][65][66][67] seems to be an interesting alternative not only to increase the sample size but also to exclude effects of practitioner bias and the experimental/clinical atmosphere [66].…”

Section: Sleep Variable After Acupuncture After Waitlistmentioning

confidence: 99%

Sleep disorders in patients with depression or schizophrenia: A randomized controlled trial using acupuncture treatment

Bosch

Noort

Staudte³

et al. 2016

European Journal of Integrative Medicine

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“…We excluded studies that used pain as an inclusion or exclusion criterion, studies on induced pain (e.g. [13]), case reports or case series. Authors were contacted when studies reported one or more dementia subtypes, but did not display the results of the subtypes separately.…”

Section: Methodsmentioning

confidence: 99%

A Review of Pain Prevalence in Alzheimer's, Vascular, Frontotemporal and Lewy Body Dementias

Kooten

Binnekade²,

Wouden

et al. 2016

Dement Geriatr Cogn Disord

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Background: Numerous studies have reported on pain in dementia. It has been hypothesized that pain perception differs between dementia subtypes, and therefore, the prevalence of pain differs between dementia subtypes. However, there remains a paucity of evidence on the differences in the prevalence of pain in different dementia subtypes. This review aimed to determine the prevalence of pain for the major dementia subtypes: Alzheimer's disease (AD), vascular dementia (VaD), frontotemporal dementia (FTD) and dementia with Lewy bodies (DLB). Summary: We found 10 studies that met our inclusion criteria. Most of these studies reported on AD; studies reporting the prevalence of pain in people with DLB were scarce, and for FTD, we found no studies. The sample-weighted prevalence of pain could only be calculated for AD, VaD and mixed dementia: AD 45.8% (95% confidence interval, CI: 33.4-58.5%), VaD 56.2% (95% CI: 47.7-64.4%) and mixed dementia 53.9% (95% CI: 37.4-70.1%). Key Messages: Studies investigating the prevalence of pain in dementia subtypes were scarce; however, we found a high prevalence of pain in dementia without significant differences between the dementia subtypes. More studies are required to draw firm conclusions on the differences in the prevalence of pain between dementia subtypes.

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Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A Multicenter Study in Spain

Abstract: LP can be safely performed to study CSF biomarkers. The main complication is headache, associated with younger age and use of cutting-edge needles.

Cited by 56 publications

References 25 publications

Postdural puncture headache and epidural blood patch use in elderly patients

Postdural puncture headache and epidural blood patch use in elderly patients

Sleep disorders in patients with depression or schizophrenia: A randomized controlled trial using acupuncture treatment

A Review of Pain Prevalence in Alzheimer's, Vascular, Frontotemporal and Lewy Body Dementias

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