Feasibility of New Heating Method of Hepatic Parenchyma Using a Sintered MgFe2O4 Needle Under an Alternating Magnetic Field

Novel tumor‐ablation device for liver tumors utilizing heat energy generated under an alternating magnetic field

“…Depending on the model and heating application used, indirect heat stimulus generally continues from 24 h to 7 days after heating 24–27 . In our previous study, heat stimulus by this heat device worked for normal liver tissues up to 3 days after heating 12 . The appearance of a fibroblast layer surrounding the heat‐injury area and the results of the TUNEL examination suggest that heat stimulus tissues worked up to 3 days after heating in the present study.…”

“…We therefore developed a new needle made from MgFe 2 O 4 particles by sintering at 1100°C to concentrate heat energy into the tumor. We have previously reported that the use of this needle under an AMF safely enables heating of a normal rat liver to a temperature of 60.7 ± 1.1°C 12 . In the present study, heat treatment using a sintered MgFe 2 O 4 needle could safely heat rat liver tumors to a mean temperature of 60.2 ± 1.8°C.…”

“…We therefore manufactured a small needle by sintering MgFe 2 O 4 particles at 1100°C, and used this needle to correctly target liver tumors and obtain improved heating effects. We have previously reported that this device heats normal rat liver tissues at 60.7 ± 1.1°C and leads to hepatocyte cell death 12 . The present study assessed the heating effect on liver tumors by examining cellular activity in the heat‐injury area and sequentially evaluating the tumor diameter after heating.…”

Tumor local chemohyperthermia using docetaxel‐embedded magnetoliposomes: Interaction of chemotherapy and hyperthermia

“…For example, radiofrequency ablation (RFA) is now indispensable for local treatment of liver cancer 13–15 . We also have studied hyperthermia with inductive heating as a minimally invasive treatment for various cancers 16–23 . However, many researchers have reported that some problems with hyperthermia remain.…”

Feasibility study of high-temperature thermoseed inductive hyperthermia in melanoma treatment

“…Basic research mainly focused on heat generation by different materials (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33), thermoseed processing methods (34,35), heating coil designs (36,37), improving uniform temperature distribution (38)(39)(40)(41)(42)(43)(44)(45)(46)(47), and the in vivo effects on animals (12,21,25,28,30,32,33,36,38,41,(48)(49)(50)(51). Clinical research mainly focused on intracranial tumors (52,53), prostate cancer (54)(55)(56)57), and some other tumors …”