Feasibility of Short Imaging Protocols for [18F]PI-2620 Tau-PET in Progressive Supranuclear Palsy

Song, Mengmeng; Scheifele, Maximilian; Barthel, Henryk; Eimeren, Thilo van; Beyer, Leonie; Marek, Kenneth; Eckenweber, Florian; Palleis, Carla; Kaiser, Lena; Finze, Anika; Kern, Maike; Nitschmann, Alexander; Biechele, Gloria; Katzdobler, Sabrina; Bischof, Gérard N.; Hammes, Jochen; Jessen, Frank; Saur, Dorothee; Schroeter, Matthias L.; Rumpf, Jost‐Julian; Rullmann, Michael; Schildan, Andreas; Patt, Marianne; Stephens, Andrew; Rauchmann, Boris‐Stephan; Perneczky, Robert; Levin, Johannes; Claßen, Joseph; Neumeier, Bernd; Höglinger, Günter U.; Bartenstein, Peter; Boening, Guido; Ziegler, Sibylle; Villemagne, Victor L.; Drzezga, Alexander; Seibyl, John; Sabri, O.; Brendel, Matthias

doi:10.21203/rs.3.rs-180630/v1

Cited by 2 publications

(2 citation statements)

References 31 publications

(49 reference statements)

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“…All dynamic datasets were visually checked for artifacts and motion-corrected using rigidregistration. Mean SUV images were obtained for 20-40 min time frames to obtain SUVR images, which show comparable performance in signal sensitivity and were less subject to artifacts when compared to 0-60 min or 0-40 min DVR images 65 .…”

Section: Methodsmentioning

confidence: 99%

Tau deposition patterns are associated with functional connectivity in primary tauopathies

Franzmeier¹,

Brendel

Beyer

et al. 2022

Nat Commun

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Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4-repeat tauopathies, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assess whether connectivity is associated with 4R-tau deposition patterns by combining resting-state fMRI connectomics with both 2nd generation 18F-PI-2620 tau-PET in 46 patients with clinically diagnosed 4-repeat tauopathies and post-mortem cell-type-specific regional tau assessments from two independent progressive supranuclear palsy patient samples (n = 97 and n = 96). We find that inter-regional connectivity is associated with higher inter-regional correlation of both tau-PET and post-mortem tau levels in 4-repeat tauopathies. In regional cell-type specific post-mortem tau assessments, this association is stronger for neuronal than for astroglial or oligodendroglial tau, suggesting that connectivity is primarily associated with neuronal tau accumulation. Using tau-PET we find further that patient-level tau patterns are associated with the connectivity of subcortical tau epicenters. Together, the current study provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.

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Section: Methodsmentioning

confidence: 99%

Tau deposition patterns are associated with functional connectivity in primary tauopathies

Franzmeier¹,

Brendel

Beyer

et al. 2022

Nat Commun

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“…Mean SUV images were obtained for 20-40 min time frames to obtain SUVR images which show comparable performance in signal sensitivity and were less subject to artifacts when compared to 0-60 min or 0-40 min DVR images. 63…”

Section: Neuroimaging Acquisitionmentioning

confidence: 99%

Tau spreading is driven by neuronal connectivity in primary tauopathies - evidence from tau-PET and histopathology

Franzmeier

Brendel

Beyer

et al. 2021

Preprint

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Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies (4RT), including cortico-basal degeneration and progressive supranuclear palsy (PSP). Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4RTs, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assessed whether connectivity drives 4R-tau spreading patterns by combining resting-state fMRI connectomics with both 2nd generation 18F-PI-2620 tau-PET in 46 patients with clinically diagnosed 4RTs and post-mortem cell-type-specific regional tau assessments from two independent PSP samples (n=97/96). We found that inter-regional connectivity was associated with higher inter-regional correlation of both tau-PET and post-mortem tau levels in 4RTs. In regional cell-type specific post-mortem tau assessments, this association was stronger for neuronal than for astroglial or oligodendroglial tau, suggesting that connectivity is primarily associated with trans-neuronal tau spread. Using tau-PET we found that patient-level tau patterns can be predicted by the connectivity of subcortical tau epicenters. Together, the current study provides combined in vivo tau-PET and histopathological evidence for brain connectivity as a key mediator of trans-neuronal tau spreading in 4RTs.

show abstract

Feasibility of Short Imaging Protocols for [18F]PI-2620 Tau-PET in Progressive Supranuclear Palsy

Cited by 2 publications

References 31 publications

Tau deposition patterns are associated with functional connectivity in primary tauopathies

Tau deposition patterns are associated with functional connectivity in primary tauopathies

Tau spreading is driven by neuronal connectivity in primary tauopathies - evidence from tau-PET and histopathology

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