Feasibility of Template-Guided Attenuation Correction in Cat Brain PET Imaging

Kim, Jin S U; Lee, Jae Sung; Park, Min Hyun; Kim, Kyeong Min; Oh, Seung Ha; Cheon, Gi Jeong; Song, In Chan; Moon, Dae Hyuk; Chung, June Key; Lee, Dong Hoon

doi:10.1007/s11307-009-0277-1

Cited by 10 publications

(8 citation statements)

References 42 publications

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“…For the successful implementation of inverse spatial normalization, spatial normalization onto the template is important [14]. In our present study, we applied the SPAM-assisted presurgical evaluation of brain tumors to FLT PET data because FLT PET data lack specific anatomical information.…”

Section: Discussionmentioning

confidence: 99%

Presurgical Mapping of Brain Tumors Using Statistical Probabilistic Anatomical Maps

Kim¹,

Cheon²,

Lim³

2015

JBiSE

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Purpose: Multi-tracer neuroimaging is widely used for the diagnosis, radiotherapy, and neurosurgery of brain gliomas. Anatomical and functional information is important to avoid having neurological deficits induced during the resection or radiation therapy of brain gliomas. The aim of this study was to investigate presurgical anatomical labeling of brain gliomas on FLT and FET using statistical probabilistic anatomic maps (SPAM), which are images of cerebral cortical, cerebellar, and subcortical volumes of interest (VOIs). Methods: FDG, FLT, and FET PET scans were acquired. FLT and FET PET images were coregistered to the FDG PET images, which were then spatially normalized onto the target brain. An inverse spatial normalization parameter was calculated and applied to SPAM. For the anatomical labeling of brain glioma regions, the volumes of brain gliomason FLT and FET images were extracted using segmentation. Probabilistic information of the glioma region was then calculated using SPAM and the segmented glioma volumes. SPM and an in-house program were used for image processing. Results: The probability of SPAM labeling a brain glioma region could be extracted using the inverse normalized SPAM and segmented glioma regions. In a sample case, the probabilistic anatomical region of the glioma included 21% of the postcentral gyrus, 12% of the superior parietal gyrus, and 6% of the angular gyrus. Conclusion: Anatomical information about brain gliomas could be extracted using SPAM. This proposed method would be optional for presurgical mapping, to avoid an additional functional mapping study that might otherwise be necessary to avoid producing neurological deficits.

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Section: Discussionmentioning

confidence: 99%

Presurgical Mapping of Brain Tumors Using Statistical Probabilistic Anatomical Maps

Kim¹,

Cheon²,

Lim³

2015

JBiSE

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“…Several template-guided (or atlas-based) and segmentation-based methods have been suggested for MRI-based attenuation correction ( 35 , 36 , 37 ). In template-guided attenuation correction approaches, the template of the PET attenuation map is transformed into an individual space using the transformation parameters obtained by the nonlinear registration of individual and template MR or the emission PET data ( 35 , 36 ). The template-guided attenuation correction has been well established, especially for brain PET data.…”

Section: Technical Challenges Of Mr/pet Compared With Pet/ctmentioning

confidence: 99%

Integrated Whole Body MR/PET: Where Are We?

Yoo

Lee

2015

Korean J Radiol

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Whole body integrated magnetic resonance imaging (MR)/positron emission tomography (PET) imaging systems have recently become available for clinical use and are currently being used to explore whether the combined anatomic and functional capabilities of MR imaging and the metabolic information of PET provide new insight into disease phenotypes and biology, and provide a better assessment of oncologic diseases at a lower radiation dose than a CT. This review provides an overview of the technical background of combined MR/PET systems, a discussion of the potential advantages and technical challenges of hybrid MR/PET instrumentation, as well as collection of possible solutions. Various early clinical applications of integrated MR/PET are also addressed. Finally, the workflow issues of integrated MR/PET, including maximizing diagnostic information while minimizing acquisition time are discussed.

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“…The template-guided attenuation correction method uses the template images of the attenuation map and a spatial normalization algorithm to transform the template into an individual attenuation map. [88][89][90] However, the use of the relatively robust template-guided attenuation correction is possible only for the brain because current spatial normalization methods cannot fully accommodate the wide interindividual anatomical variability of whole-body images. The segmentation-based attenuation correction method segments and categorizes tissue groups on the basis of their MR intensities.…”

Section: Attenuation Correction: Unsolved Issue In Pet/mrmentioning

confidence: 99%

Recent Advances in Hybrid Molecular Imaging Systems

Lee

Kim

2014

Semin Musculoskelet Radiol

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Nuclear medicine imaging methods that use radionuclides, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), offer highly sensitive and quantitative tools for the detection and localization of the biochemical and functional abnormalities associated with various diseases. The introduction of dual-modality PET/CT and SPECT/CT systems to the clinical environment in the late 1990s is regarded as a revolutionary advance in modern diagnostic imaging, bringing precise anatomical localization to conventional PET and SPECT imaging techniques and enhancing the quantitation capabilities of these modalities. The great success of PET/CT has also revived interest in the combination of PET and MR scanners, leading to commercially available clinical PET/MR systems. In this article, we review the recent improvements made in these hybrid molecular imaging systems, which have been dramatic in terms of both hardware and software over the past decade. We focus primarily on the hybrid imaging systems that are currently used in clinical practice and the technologies applied in those systems, with emphasis on the efforts to improve their diagnostic performances for musculoskeletal diseases.

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Feasibility of Template-Guided Attenuation Correction in Cat Brain PET Imaging

Cited by 10 publications

References 42 publications

Presurgical Mapping of Brain Tumors Using Statistical Probabilistic Anatomical Maps

Presurgical Mapping of Brain Tumors Using Statistical Probabilistic Anatomical Maps

Integrated Whole Body MR/PET: Where Are We?

Recent Advances in Hybrid Molecular Imaging Systems

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