Feasibility Study for Production of Iodine-131 Using Dioxide of Tellurium-130

Didi, Abdessamad; Dadouch, Ahmed; Bekkouri, Hassane El

doi:10.22159/ijpps.2016v8i11.13595

Cited by 20 publications

(5 citation statements)

References 30 publications

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“…Radioactive isotopes of elements have been utilized for medical use from decades [71][72][73][74][75][76][77][78][79][80][81][82][83] radioactive isotopes loaded microspheres are used to treat several diseases such as liver and spleen tumor, for example, Yttrium 90 loaded microspheres are used to treat carcinoma [84].…”

Section: Radioactive Applicationmentioning

confidence: 99%

A Review on Microspheres as a Novel Controlled Drug Delivery System

Samanta¹,

Gautam²,

Chandel³

et al. 2021

Asian J Pharm Clin Res

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Over the past three decades, controlled drug delivery systems have become more developed and play a key role in pharmaceuticals formulations. There are many shortcomings in Traditional or Conventional drug delivery systems like for maintaining desired therapeutic drug plasma concentration there is a need for frequent dosing for particular drugs having shorter half-lives. Furthermore, because of frequent dosing requirement, there is poor patient compliance which causes fluctuation in plasma concentration of the drug. The limitations of conventional drug delivery can be overcome by the development of novel drug delivery systems, of which the controlled drug delivery can maintain constant drug plasma concentration by slowly releasing the drug over an extended period. Developing controlled drug delivery systems can also improve the systemic bioavailability of the drug, thus enhancing the therapeutic efficacy of the drug and better patient compliance. There are many different approaches for such controlled delivery systems such as liposomes, niosomes, ethosomes, phytosomes, microemulsion, and microspheres. Among all the approaches microspheres are more convenient as the drug is slowly released from the polymeric matrix and the polymers used are mostly biodegradable and possess no side effects. Therefore, microspheres can be used in various medicinal departments such as oncology, gynecology, radiology, pulmonary, cardiology, diabetes, and vaccine therapy. This review article focuses on recent different types of microspheres along with their methods of preparation. The microspheres formulated can be later evaluated and characterized by different procedures.

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Section: Radioactive Applicationmentioning

confidence: 99%

A Review on Microspheres as a Novel Controlled Drug Delivery System

Samanta¹,

Gautam²,

Chandel³

et al. 2021

Asian J Pharm Clin Res

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show abstract

“…The number density of I-131 can be calculated by equation [9]: With  is micro cross section (barn);  is neutron flux (n/cm 2 .s);  is decay constant (s -1 ) and N is the number density of isotopes (atoms/cm 3 ).…”

Section: I-131 Activity Calculation After Its Irradiation and Coolingmentioning

confidence: 99%

Calculation Results for Enhancing Ability of I-131 Radioisotope Production Using Tellurium Dioxide Target on the Dalat Nuclear Research Reactor

Kien¹,

Ton²,

Vinh³

et al. 2021

Nucl. Sci. and Tech.

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The paper presents the calculation results in re-design of neutron trap of the Dalat Nuclear Research Reactor (DNRR) for I-131 radioisotope production using TeO2 target. The new design permits for loading more TeO2 capsules from 9 to 12, 15 and 18 in the neutron trap. The enhancement of radioisotope production was implemented by re-arrangement of the neutron trap without changing the dimension or geometry of irradiation capsules. By using neutronics computer code as MCNP6, the obtained calculation results of I-131 activity in 6 investigated cases showed that the new design by the re-arrangement of the neutron trap can be used effectively for radioisotope production with thermal neutron flux in average range from 5.3×1012 to 1×1013 n/cm2.s and the total activity of I-131 isotope was increased from about 19.2% to 38.8% comparing with the original design using 9 capsules. The negative reactivity insertion was from 0.60 βeff to 0.96 βeff when loading capsules that also met the safety requirements of operational conditions of the DNRR.

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“…In this method, the radionuclides are prepared in the nuclear reactor by bombarding the non-radionuclide by neutrons [33]. Didi et al studied the feasibility of the production of iodin-131 using dioxide of tellurium-130 under neutron activation [34].…”

Section: • Neutron Bombardmentmentioning

confidence: 99%

Review About Radiopharmaceuticals: Preparation, Radioactivity, and Applications

et al. 2020

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In the recent few decades, there was a growth in the field of radioactive medicinal agents called radiopharmaceuticals. Radiopharmaceuticals are consisting of radioactive materials called radioisotopes. Radiopharmaceuticals were recently used in both therapeutic and diagnostic purposes. More than 100 radioactive substances are used in nuclear medicine. According to the decay of radioactive substances, there are three types of radioactive decays, alpha particles, beta particles, and gamma radiations. Alpha particles consist of two protons and two neutrons with large mass and charge so it has no penetration power into the skin and has a destructive effect. Beta particles have less charge and less mass so, they can penetrate the tissue and have a less destructive effect than alpha particles and can be used in therapy. Gamma radiations have no mass or charge so they can penetrate the deep tissue of organs so used in diagnosis by imaging using a gamma camera. The radiopharmaceuticals were established in the diagnostic purpose and treatment of several diseases as thyroid gland cancer, hyperthyroidism, bone pain metastasis, kidney dysfunction, and myocardial and cerebral perfusion. The radioactive substance can also be used in the sterilization of thermo-labile substances as syringes, catheters, vitamins, hormones, and surgical dressing. The field of nuclear medicine has several advantages as localization of tumors, safe diagnosis, no accumulation of radiation, and high therapeutic efficacy. Nowadays, the branch of nuclear pharmacy is directed to introduce new radioactive pharmaceutical agents which will be important and effective in the treatment of cancer. The growth in the field of radiopharmaceuticals is important to help millions of patients suffering from tumors all over the world. The data of this review were collected by searching in Google Scholar and PubMed using the following keywords.

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Feasibility Study for Production of Iodine-131 Using Dioxide of Tellurium-130

Cited by 20 publications

References 30 publications

A Review on Microspheres as a Novel Controlled Drug Delivery System

A Review on Microspheres as a Novel Controlled Drug Delivery System

Calculation Results for Enhancing Ability of I-131 Radioisotope Production Using Tellurium Dioxide Target on the Dalat Nuclear Research Reactor

Review About Radiopharmaceuticals: Preparation, Radioactivity, and Applications

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