Feasibility study of collagen membranes derived from bovine pericardium and intestinal serosa for the repair of cranial defects in ovariectomised rats

Hirata, Helton Hiroshi; Munhoz, M.A.S.; Plepis, Ana Maria de Guzzi; Martins, Virgínia da Conceição Amaro; Santos, Geovane Ribeiro dos; Galdeano, Ewerton Alexandre; Cunha, Marcelo Rodrigues da

doi:10.1016/j.injury.2015.03.039

Cited by 20 publications

(23 citation statements)

References 25 publications

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“…The radiopacity of the latter is insufficient to be detected upon radiographic examination. Thus, the radiological results observed were similar to those reported in the literature 28,29 . A denser image was noted in the center of the cranial defect in G2 and G3, which was due to the presence of the biomembranes that were not reabsorbed within the experimental period established in this study.…”

Section: Macroscopic and Radiological Analysissupporting

confidence: 90%

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In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes

et al. 2017

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Biomaterials with the hydroxyapatite and biopolymers such as chitosan derived of crustaceans are is an alternative for bone repair. Carbon nanotubes have been a focus of interest because they can ameliorate the biomechanical properties of biomaterials. The objective of this study was to evaluate these materials in the repair of cranial defects in rats. The animals were divided in groups: without implant (G1), implanted with the chitosan/carbon nanotube membrane (G2), and chitosan/nanotube membrane mineralized with hydroxyapatite (G3). The animals were sacrificed 5 weeks after surgery and the skulls were removed for analysis of the defect area. The results showed absence of chronic inflammatory and little bone neoformation in the defect area of all groups. In G2 and G3 there was lack of reabsorption of the biomaterial that were encapsulated by connective tissue. In conclusion, the biomaterials were biocompatible, but their specific physicochemical properties did not indicate a considerable osteoregenerative capacity.

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Section: Macroscopic and Radiological Analysissupporting

confidence: 90%

“…Previous researches used defects of 5mm [23][24][25] . The rat skullcap has two parietal bones (right and left) separated by a sagittal suture of medium (middle) location.…”

Section: Discussionmentioning

confidence: 99%

In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes

et al. 2017

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“…Moreover, maxillofacial implants are less frequent, with 2 studies in which the mandible was the implant site, although recent literature highlights that oestrogen loss strongly influences bone resorption in the mandible [96] and clinical evidence have shown that the depth of mandibular incisure can be evaluated for early detection of OP [97]. Critical size defects are also performed in calvaria bone, despite even in this case where there are only few works about but this site is more and more used for studies related to OP [98,99] (Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Functionalization of Ceramic Coatings for Enhancing Integration in Osteoporotic Bone: A Systematic Review

et al. 2019

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Background: The success of reconstructive orthopaedic surgery strongly depends on the mechanical and biological integration between the prosthesis and the host bone tissue. Progressive population ageing with increased frequency of altered bone metabolism conditions requires new strategies for ensuring an early implant fixation and long-term stability. Ceramic materials and ceramic-based coatings, owing to the release of calcium phosphate and to the precipitation of a biological apatite at the bone-implant interface, are able to promote a strong bonding between the host bone and the implant. Methods: The aim of the present systematic review is the analysis of the existing literature on the functionalization strategies for improving the implant osteointegration in osteoporotic bone and their relative translation into the clinical practice. The review process, conducted on two electronic databases, identified 47 eligible preclinical studies and 5 clinical trials. Results: Preclinical data analysis showed that functionalization with both organic and inorganic molecules usually improves osseointegration in the osteoporotic condition, assessed mainly in rodent models. Clinical studies, mainly retrospective, have tested no functionalization strategies. Registered trademarks materials have been investigated and there is lack of information about the micro- or nano- topography of ceramics. Conclusions: Ceramic materials/coatings functionalization obtained promising results in improving implant osseointegration even in osteoporotic conditions but preclinical evidence has not been fully translated to clinical applications.

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“…Moraes (2017) (MUNHOZ et al, 2013;HIRATA et al, 2015;MACHADO et al, 2018). A BMP comercializada e a HA sintetizada foram também biocompatíveis conforme já demonstrado em pesquisas anteriores (MORAES, 2017;JUNG et al, 2017).…”

Section: Biocompatibilidadeunclassified

“…Além disso o processo de biodegradação concomitante taxa de neoformação óssea é essencial pois promove a proliferação celular e ao mesmo tempo permite espaço para o crescimento ósseo (EBRAHIMI; BOTELHO; DOROZHKIN, 2017). Desta maneira analisou-se no presente estudo o comportamento das membranas utilizadas, as quais permaneceram alguns resquícios nas áreas implantadas conforme também descrito em estudos anteriores (CUNHA et al, 2008;MUNHOZ, 2013;HIRATA et al, 2015).…”

Section: Biodegradabilidadeunclassified

Estudo comparativo de membrana serosa porcina e de elastina no reparo de defeitos na calvária de ratos

Cunha¹

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Feasibility study of collagen membranes derived from bovine pericardium and intestinal serosa for the repair of cranial defects in ovariectomised rats

Cited by 20 publications

References 25 publications

In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes

In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes

Functionalization of Ceramic Coatings for Enhancing Integration in Osteoporotic Bone: A Systematic Review

Estudo comparativo de membrana serosa porcina e de elastina no reparo de defeitos na calvária de ratos

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