Feasibility Study of Using Gemstone Spectral Imaging (GSI) and Adaptive Statistical Iterative Reconstruction (ASIR) for Reducing Radiation and Iodine Contrast Dose in Abdominal CT Patients with High BMI Values

Zhu, Zheng; Zhao, Xinming; Zhao, Yanfeng; Wang, Xiaoyi; Zhou, Chunwu

doi:10.1371/journal.pone.0129201

Cited by 29 publications

(21 citation statements)

References 22 publications

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“…So far, some commercially available scanners are fast enough and have been used in vascular imaging enhanced by non-ionic iodinated contrast agents [21, 40]. High performance reconstruction methods, which need fewer exposures, will also reduce the requirements of imaging speed and contrast agents [41, 42]. …”

Section: Discussionmentioning

confidence: 99%

A Novel Mouse Segmentation Method Based on Dynamic Contrast Enhanced Micro-CT Images

et al. 2017

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With the development of hybrid imaging scanners, micro-CT is widely used in locating abnormalities, studying drug metabolism, and providing structural priors to aid image reconstruction in functional imaging. Due to the low contrast of soft tissues, segmentation of soft tissue organs from mouse micro-CT images is a challenging problem. In this paper, we propose a mouse segmentation scheme based on dynamic contrast enhanced micro-CT images. With a homemade fast scanning micro-CT scanner, dynamic contrast enhanced images were acquired before and after injection of non-ionic iodinated contrast agents (iohexol). Then the feature vector of each voxel was extracted from the signal intensities at different time points. Based on these features, the heart, liver, spleen, lung, and kidney could be classified into different categories and extracted from separate categories by morphological processing. The bone structure was segmented using a thresholding method. Our method was validated on seven BALB/c mice using two different classifiers: a support vector machine classifier with a radial basis function kernel and a random forest classifier. The results were compared to manual segmentation, and the performance was assessed using the Dice similarity coefficient, false positive ratio, and false negative ratio. The results showed high accuracy with the Dice similarity coefficient ranging from 0.709 ± 0.078 for the spleen to 0.929 ± 0.006 for the kidney.

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Section: Discussionmentioning

confidence: 99%

A Novel Mouse Segmentation Method Based on Dynamic Contrast Enhanced Micro-CT Images

et al. 2017

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“…To overcome this adverse effect, we used the dual-energy spectral CT imaging mode, especially the low-energy monochromatic images for patients in Group A. Dual-energy spectral CT provides images in the energy ranges of 40–140 keV through analysis of two groups of data from 80 kVp to 140 kVp obtained with fast kVp switching. [2728] Based on the theory that low-energy X-rays can improve the contrast between high-density and low-density objects, some scholars have attempted enhanced CT diagnosis with low energy,[28293031] and others have combined low-energy level images with low-concentration contrast,[37] especially for the aorta and the liver vascular system. We evaluated the image quality in terms of enhancement in the vessels and organ parenchyma and image noise with the use of spectral CT images in our study.…”

Section: Discussionmentioning

confidence: 99%

Contrast Dose and Radiation Dose Reduction in Abdominal Enhanced Computerized Tomography Scans with Single-phase Dual-energy Spectral Computerized Tomography Mode for Children with Solid Tumors

Gao

Liu

et al. 2017

Chinese Medical Journal

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Background:Contrast dose and radiation dose reduction in computerized tomography (CT) scan for adult has been explored successfully, but there have been few studies on the application of low-concentration contrast in pediatric abdominal CT examinations. This was a feasibility study on the use of dual-energy spectral imaging and adaptive statistical iterative reconstruction (ASiR) for the reduction of radiation dose and iodine contrast dose in pediatric abdominal CT patients with solid tumors.Methods:Forty-five patients with solid tumors who had initial CT (Group B) and follow-up CT (Group A) after chemotherapy were enrolled. The initial diagnostic CT scan (Group B) was performed using the standard two-phase enhanced CT with 320 mgI/ml concentration contrast, and the follow-up scan (Group A) was performed using a single-phase enhanced CT at 45 s after the beginning of the 270 mgI/ml contrast injection using spectral mode. Forty percent ASiR was used for the images in Group B and monochromatic images with energy levels ≥60 keV in Group A. In addition, filtered back-projection (FBP) reconstruction was used for monochromatic images <60 keV in Group A. The total radiation dose, total iodine load, contrast injection speed, and maximum injection pressure were compared between the two groups. The 40 keV and 60 keV spectral CT images of Group A were compared with the images of Group B to evaluate overall image quality.Results:The total radiation dose, total iodine load, injection speed, and maximum injection pressure for Group A were decreased by 19%, 15%, 34.4%, and 18.3%, respectively. The optimal energy level in spectral CT for displaying the abdominal vessels was 40 keV. At this level, the CT values in the abdominal aorta and its three branches, the portal vein and its two branches, and the inferior vena cava were all greater than 340 hounsfield unit (HU). The abdominal organs of Groups A and B had similar degrees of absolute and relative enhancement (t = 0.36 and −1.716 for liver, −0.153 and −1.546 for pancreas, and 2.427 and 0.866 for renal cortex, all P > 0.05). Signal-to-noise ratio of the abdominal organs was significantly lower in Group A than in Group B (t = −8.11 for liver, −7.83 for pancreas, and −5.38 for renal cortex, all P < 0.05). However, the subjective scores for the 40 keV (FBP) and 60 keV (40% ASiR) spectral CT images determined by two radiologists were all >3, indicating clinically acceptable image quality.Conclusions:Single-phase, dual-energy spectral CT used for children with solid abdominal tumors can reduce contrast dose and radiation dose and can also maintain clinically acceptable image quality.

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“…With the development of new CT technology, enhancement MDCT has become an established imaging technique for evaluating abdominal organs and vessels . The iterative reconstruction technique has promise for dose reduction while maintaining or even enhancing image quality at lower radiation doses . Compared with FBP‐based image reconstruction, ASIR reconstruction can reduce the radiation dose during abdominal CT by 25.1% …”

Section: Discussionmentioning

confidence: 99%

Adrenal and nephrogenic hypertension: an image quality study of low tube voltage, low-concentration contrast media combined with adaptive statistical iterative reconstruction

Shen

et al. 2016

Int J Clin Pract

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Feasibility Study of Using Gemstone Spectral Imaging (GSI) and Adaptive Statistical Iterative Reconstruction (ASIR) for Reducing Radiation and Iodine Contrast Dose in Abdominal CT Patients with High BMI Values

Cited by 29 publications

References 22 publications

A Novel Mouse Segmentation Method Based on Dynamic Contrast Enhanced Micro-CT Images

A Novel Mouse Segmentation Method Based on Dynamic Contrast Enhanced Micro-CT Images

Contrast Dose and Radiation Dose Reduction in Abdominal Enhanced Computerized Tomography Scans with Single-phase Dual-energy Spectral Computerized Tomography Mode for Children with Solid Tumors

Adrenal and nephrogenic hypertension: an image quality study of low tube voltage, low-concentration contrast media combined with adaptive statistical iterative reconstruction

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