Cleaning is one of the most important steps in the harvesting process, and the prolonged and high-load operation of the vibrating sieve can decrease its reliability. To uncover the structural flaws of the cleaning sieve in the crawler combine harvester and establish a foundation for quality inspection, this paper proposes a method for durability testing and analysis using vibration and strain signals. Via the modal analysis of the cleaning sieve, the most susceptible areas for fault signals are identified. Subsequently, a specialized test rig exclusively designed for the examination of the durability of the cleaning sieve is constructed. After following 96 h of uninterrupted operation, the vibration plate of the cleaning sieve sustains damage, resulting in atypical noise. A signal analysis reveals that the primary vibration signal of the cleaning sieve primarily consists of a fundamental frequency of 5 Hz, corresponding to the driving speed, as well as a frequency doubling signal of 50 Hz. After the occurrence of damage, the peak amplitude of the received vibration signal increases by over 86.3%. Furthermore, the strain gauge sensor situated on the support plate of the rear sieve detects anomalous signals with frequencies exceeding 300 Hz, which are accompanied by a considerable rise in the power spectral density. This research has significant importance for enhancing the service life of the cleaning sieve and optimizing the overall machine efficiency.