Features in Septic Children With or Without Severe Acute Malnutrition and the Risk Factors of Mortality

Hossain, Md. Iqbal; Chisti, Jobayer; Yoshimatsu, Shoji; Yasmin, Rehana; Ahmed, Tahmeed

doi:10.1542/peds.2014-3330q

Cited by 4 publications

(3 citation statements)

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“…It was quite revealing in our study that almost all (92%) patients with sepsis were malnourished, and 15% of these patients died in the year preceding our study. This is consistent with other studies that showed high case fatality rate in children with septic shock and severe acute malnutrition, with mortality rate as high as 40% (39, 40). To date, issues related to fluid resuscitation in the malnourished child remain unsettled.…”

Section: Discussionsupporting

confidence: 93%

A National Survey of Resources to Address Sepsis in Children in Tertiary Care Centers in Nigeria

et al. 2019

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Background: Infections leading to sepsis are major contributors to mortality and morbidity in children world-wide. Determining the capacity of pediatric hospitals in Nigeria to manage sepsis establishes an important baseline for quality-improvement interventions and resource allocations. Objectives: To assess the availability and functionality of resources and manpower for early detection and prompt management of sepsis in children at tertiary pediatric centers in Nigeria. Methods: This was an online survey of tertiary pediatric hospitals in Nigeria using a modified survey tool designed by the World Federation of Pediatric Intensive and Critical Care Societies (WFPICCS). The survey addressed all aspects of pediatric sepsis identification, management, barriers and readiness. Results: While majority of the hospitals 97% (28/29) reported having adequate triage systems, only 60% (16/27) follow some form of guideline for sepsis management. There was no consensus national guideline for management of pediatric sepsis. Over 50% of the respondents identified deficit in parental education, poor access to healthcare services, failure to diagnose sepsis at referring institutions, lack of medical equipment and lack of a definitive protocol for managing pediatric sepsis, as significant barriers. Conclusions: Certain sepsis-related interventions were reportedly widespread, however, there is no standardized sepsis protocol, and majority of the hospitals do not have pediatric intensive care units (PICU). These findings could guide quality improvement measures at institutional level, and healthcare policy/spending at the national level.

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Section: Discussionsupporting

confidence: 93%

A National Survey of Resources to Address Sepsis in Children in Tertiary Care Centers in Nigeria

et al. 2019

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“…These findings from other research groups agree with our results showing that IGF-1 and IGFBP- 3 concentrations decrease with WHZ and are lowest in SAM. As immunity is heavily impaired in children experiencing SAM [77] , the predictive associations between Enterobacteriacea and IGF-1 are not surprising. However, it is not uncommon for children experiencing SAM to develop septicaemia [ 63 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

“…As immunity is heavily impaired in children experiencing SAM [77] , the predictive associations between Enterobacteriacea and IGF-1 are not surprising. However, it is not uncommon for children experiencing SAM to develop septicaemia [ 63 , 77 ]. Previous research has shown that patients with sepsis have low levels of IGF-1 inversely correlated with enteric bacterial load [78] .…”

Section: Discussionmentioning

confidence: 99%

Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children

et al. 2021

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Treatment outcomes and determinants of mortality in children aged 0-59 months diagnosed with complicated severe acute malnutrition in two referral hospitals in Ghana

Carboo

Asare

Ricci

et al. 2020

Vulnerable Children and Youth Studies

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Features in Septic Children With or Without Severe Acute Malnutrition and the Risk Factors of Mortality

Cited by 4 publications

References 0 publications

A National Survey of Resources to Address Sepsis in Children in Tertiary Care Centers in Nigeria

A National Survey of Resources to Address Sepsis in Children in Tertiary Care Centers in Nigeria

Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children

Treatment outcomes and determinants of mortality in children aged 0-59 months diagnosed with complicated severe acute malnutrition in two referral hospitals in Ghana

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