The purpose of the present study was to investigate the predictive contribution of attitude to life and belief system on self-resilience and psychological toughness of cancer patients about the mediating role of emotion regulation. The current research is fundamental in terms of its purpose and descriptive of correlation type in terms of method. The statistical population consists of all cancer patients of Shahinshahr city. The sample size was 150 people based on Cochran's formula and the country's corona situation. The sampling method of the current research is available. This research used tools of attitude to life, belief system, self-resilience, psychological toughness, and emotion regulation, all of which had acceptable reliability and validity. The research data was done in two parts, descriptive and inferential, with the help of Excel, SPSS, and SmartPLS software. The results showed that the attitude towards life and the belief system with the role of mediating emotion regulation has a significant predictive ability on the self-resilience of cancer patients. Also, attitude towards life and belief systems with the role of mediating emotion regulation can predict the psychological toughness of cancer patients. In addition, emotional regulation has a significant relationship with self-resilience and psychological toughness. According to the research results, it can be concluded that the attitude towards life and the belief system mediating emotion regulation can predict cancer patients' resilience and psychological toughness. Also, the attitude toward life and the belief system directly impacts. In addition, attitude towards life has a direct positive relationship with psychological toughness.