Features of HPV infection among the healthy attendants of gynecological practice in St. Petersburg, Russia

Alexandrova, Yuliya N; Lyshchov, Anton A.; Safronnikova, N. R.; Imyanitov, Evgeny N.; Hanson, Kaido P.

doi:10.1016/s0304-3835(99)00218-9

Cited by 14 publications

(9 citation statements)

References 16 publications

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“…The prevalence of HPV-DNA in healthy controls has been reported to vary greatly between populations, ranging from 1% in Spain to 26% in Nigeria [Clifford et al, 2005], the mean prevalence being around 16% [Munoz et al, 2003], which is similar as recently reported in Latin America [Syrjä nen et al, 2005a]. The prevalence of high-risk HPV infections in cytologically normal women in the present series was higher (27.4%) than this global average, which was partly expected on the basis of previously reported HPV prevalence (29%) among healthy Russian women [Alexandrova et al, 1999]. The current data are consonant with the type distribution reported by Alexandrova et al [1999] in Russia, and also confirmed in a recent meta-analysis [Munoz et al, 2003].…”

Section: Discussionsupporting

confidence: 91%

“…The most likely explanations are that the method used in the present study is the most sensitive one, and that the general population might have a higher HPV prevalence compared to many other countries. This is also supported by other studies [Alexandrova et al, 1999]. The type distribution profile in the sexually transmitted disease clinic group was not markedly different from that of the two other groups, except for the higher frequency of multiple infections.…”

Section: Discussionsupporting

confidence: 84%

“…The prevalence of high-risk HPV infections in cytologically normal women in the present series was higher (27.4%) than this global average, which was partly expected on the basis of previously reported HPV prevalence (29%) among healthy Russian women [Alexandrova et al, 1999]. The current data are consonant with the type distribution reported by Alexandrova et al [1999] in Russia, and also confirmed in a recent meta-analysis [Munoz et al, 2003]. In this meta-analysis, HPV18 was the second most prevalent type in controls, while in the present population it was HPV31.…”

Section: Discussionsupporting

confidence: 50%

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Prevalence of the most common high‐risk HPV genotypes among women in three new independent states of the former Soviet Union

Kulmala

Shabalova

Petrovitchev

et al. 2007

Journal of Medical Virology

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Type distribution of HPV has been studied in different geographic regions, but the data are scanty from the new independent states of the former Soviet Union. Here the HPV prevalence and distribution of the most frequent high-risk HPV types among 3,187 women at different risk for HPV and cervical intraepithelial neoplasia in Russia, Belarus, and Latvia is reported. HPV detection, type distribution and viral load analysis in DNA samples from cervical scrapes were done with real-time PCR-based assay detecting HPV types 16, 18, 31, 33, 35, 39, 45, 52, and 58. The overall HPV prevalence was 31.2%, HPV16 was the most prevalent type followed by HPV31 and HPV33 group. The overall HPV prevalences in Russia, Belarus and Latvia were 33.4%, 27.5%, and 26.2%. The type distributions were similar in these countries, except for Latvia where HPV39 was the third prevalent genotype. HPV prevalence was highest (40.8%) among women from sexually transmitted disease clinic, followed by 30.9% among gynecological outpatients and 27.2% in screening patients. HPV detection increased with cytological abnormality (P = 0.0001) and lesion grade in the biopsy (P = 0.0001), from 27% to 72% in normal samples to cancer, and from 64% to 77% in cervical intraepithelial neoplasia 1 to cancer. The normalized viral loads varied greatly between and among different HPV-types. The mean log HPV33 group copies/cell increased from negative for intraepithelial lesions to cancer (P = 0.049). Distribution of the most common high-risk HPV-types seems to be similar in these countries as reported in other major geographical regions.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 50%

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Prevalence of the most common high‐risk HPV genotypes among women in three new independent states of the former Soviet Union

Kulmala

Shabalova

Petrovitchev

et al. 2007

Journal of Medical Virology

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“…According to official estimates, in 2009 10% of maternal deaths in Russia were related to abortion [8], which is approximately twice as high as countries in Western Europe [9]. In Russia repeat abortion is also linked to higher incidence of sexually transmitted infections [10] and there is a link between repeat abortion and adverse outcomes in future pregnancies [11]. Therefore, research is needed to understand the determinants of abortion in Russia, particularly repeat abortion [12].…”

Section: Introductionmentioning

confidence: 99%

Women's Risk of Repeat Abortions Is Strongly Associated with Alcohol Consumption: A Longitudinal Analysis of a Russian National Panel Study, 1994–2009

et al. 2014

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Abortion rates in Russia, particularly repeat abortions, are among the highest in the world, and abortion complications make a substantial contribution to the country's high maternal mortality rate. Russia also has a very high rate of hazardous alcohol use. However, the association between alcohol use and abortion in Russia remains unexplored. We investigated the longitudinal predictors of first and repeat abortion, focussing on women's alcohol use as a risk factor. Follow-up data from 2,623 women of reproductive age (16–44 years) was extracted from 14 waves of the Russian Longitudinal Monitoring Survey (RLMS), a nationally representative panel study covering the period 1994–2009. We used discrete time hazard models to estimate the probability of having a first and repeat abortion by social, demographic and health characteristics at the preceding study wave. Having a first abortion was associated with demographic factors such as age and parity, whereas repeat abortions were associated with low education and alcohol use. After adjustment for demographic and socioeconomic factors, the risk of having a repeat abortion increased significantly as women's drinking frequency increased (P<0.001), and binge drinking women were significantly more likely to have a repeat abortion than non-drinkers (OR 2.28, 95% CI 1.62–3.20). This association was not accounted for by contraceptive use or a higher risk of pregnancy. Therefore the determinants of first and repeat abortion in Russia between 1994–2009 were different. Women who had repeat abortions were distinguished by their heavier and more frequent alcohol use. The mechanism for the association is not well understood but could be explained by unmeasured personality factors, such as risk taking, or social non-conformity increasing the risk of unplanned pregnancy. Heavy or frequent drinkers constitute a particularly high risk group for repeat abortion, who could be targeted in prevention efforts.

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“…Reports about seroprevalence of specific infectious agents in Russian healthy populations are now presented, e.g. the HPV occurrence among healthy Russian women is found to be within the range of worldwide variations (7).…”

mentioning

confidence: 99%

Seropositivity of cytomegalovirus, parvovirus and rubella in pregnant women and recurrent aborters in Leningrad County, Russia

Odland

Sergejeva

Ivaneev

et al. 2001

Acta Obstet Gynecol Scand

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The mean age of the two groups was 27.1 and 28.2 years, respectively. The mean number of deliveries was low (0.4 and 0.5, respectively). Thirty-one point six percent of Group 1 and 41.9% of Group 2 were daily smokers. The group of normally pregnant women had a significantly increased frequency of induced abortions compared to the recurrent aborters, while the recurrent aborters reported more genital infections. There was little difference in total antibodies to cytomegalovirus (CMV) (78.0% and 81.1%, respectively) or B19 IgG (75.3% and 66.9%, respectively) between the groups, while the normal pregnant women had a significantly higher prevalence of rubella antibodies (77.5% and 59.8%, respectively). Our results indicate that less women remain susceptible to primary CMV infection in pregnancy in Russia compared to western Europe and North America. The prevalence of B19 IgG was slightly lower than data from Sweden. Natural immunization against rubella virus was lower than in other, unvaccinated female populations. Vaccination strategies for rubella are now initiated in the Russian Federation. Results from this study are utilized in a federally supported, comprehensive pregnancy care project of North-West Russia.

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Features of HPV infection among the healthy attendants of gynecological practice in St. Petersburg, Russia

Cited by 14 publications

References 16 publications

Prevalence of the most common high‐risk HPV genotypes among women in three new independent states of the former Soviet Union

Prevalence of the most common high‐risk HPV genotypes among women in three new independent states of the former Soviet Union

Women's Risk of Repeat Abortions Is Strongly Associated with Alcohol Consumption: A Longitudinal Analysis of a Russian National Panel Study, 1994–2009

Seropositivity of cytomegalovirus, parvovirus and rubella in pregnant women and recurrent aborters in Leningrad County, Russia

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