Features of Immune Regulation and Apoptpsis Inchildren Under Industrial Exposure

Dolgikh, O.V.; Starkova, K. G.; Alikina, I. N.; Chelakova, Yu. A.; Otavina, E. A.; Nikonoshina, N. A.

doi:10.17072/1994-9952-2019-1-84-89

Cited by 3 publications

(1 citation statement)

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“…The study indicates significant changes in the immune system of schoolchildren in living conditions with a high industrial load, and for students of the middle stage of education, more significant changes in immune reactivity are characteristic, which indicates the significant importance of both the specificity of the external environment and the duration of exposure, and the age characteristics of children [12,13]. Numerous scientific works confirm the relevance of studying the characteristics of the response of the immune regulation system in conditions of unfavorable environmental influences among different age groups of the population, children are especially sensitive to changes in living conditions, which is associated with imperfect adaptive mechanisms and, with an increased contaminant load, can determine the formation of a high level of morbidity in areas of ecological trouble [14][15][16].…”

Section: Resultsmentioning

confidence: 85%

Some Aspects of Immune Status of Primary and Secondary Schoolchildren Living in Conditions of Technogenic Pollution of Urban Environment by Industrial Pollutants

Starkova¹,

Dolgikh²

2022

Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)

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Under conditions of intensive industrial impact, the study of the specifics of the regulatory systems response will benefit effective implementation of measures aimed to preserve the health of the child population. We have studied the indicators of the immune status of schoolchildren at different levels of education under the industrial impact of the urban environment. CD-populations of lymphocytes have been studied by flow cytometry. Humoral immunity has been assessed based on the production of serum immunoglobulins by radial immunodiffusion, and specific antibodies to chemical factorsby allergosorbent testing. It has been revealed that the immune profile imbalance is especially pronounced in middle school students and is characterised by the following: a decrease in CD19 + and CD8 + lymphocytes, a reduced phagocytic activity, an increase in IgM and IgA production, a high level of sensitization for specific IgE to manganese, nickel, formaldehyde, IgG to lead, benzene, phenol, changes in the cytokine markers of interleukin-4 and interferon-gamma. These indicators reflect the state of immunological health of schoolchildren and serve as indicators of the formation of pathological trends in the context of industrial changes of the environment, which can be used for early detection of immune-mediated morbidity and development of effective preventive measures to improve the quality of life and provide a decrease in the incidence rate of children.

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Section: Resultsmentioning

confidence: 85%

Some Aspects of Immune Status of Primary and Secondary Schoolchildren Living in Conditions of Technogenic Pollution of Urban Environment by Industrial Pollutants

Starkova¹,

Dolgikh²

2022

Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)

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Hygienic Assessment of Ambient Air Pollution, Health Status and Laboratory Parameters of Workers and Residents of the Oil Production Area

Барышников¹,

Zinberg²,

Kryazhev³

et al. 2022

PH&LE

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Introduction: Petroleum industry is a fundamental part of the economy of the Russian Federation. One of the approaches to up-to-date assessment of human health effects of subthreshold concentrations of pollutants is to determine changes in the immune and hormonal status in people with non-occupational or occupational exposure to industrial contaminants. Objective: To establish body mass indices, hormonal and immune status in workers of an oil producing enterprise and the population environmentally exposed to low concentrations of airborne pollutants emitted by oil production facilities. Materials and methods: The survey covered the population living in the area affected by oil production facilities and 131 oil extraction workers. We estimated the body mass index (BMI) of the subjects and tested their blood serum for the four main classes of antibodies (immunoglobulins IgA, IgM, IgG, and IgE), circulating immune complexes (CICs), and the levels of thyroid-stimulating hormone (TSH), thyroxine (free T4), and cortisol. Results: We established that all the subjects (in both observation groups (workers (group I) and residents (group II), and the comparison group) were overweight but BMI of the industrial workers was within the normal range. We also found that the hormonal parameters did not differ significantly between the groups but the level of the stress hormone cortisol was lower among the workers. IgA and IgE levels were significantly higher in the exposed residents. A high level of circulating immune complexes in both population groups indicates high prevalence of chronic disorders. Conclusions: The study proves the need for an in-depth study of indices of the endocrine and immune systems and a clinical examination of both the exposed population and industrial workers. It is especially important to study the markers of exposure to oil production emissions in the biological media of the general population.

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Features of the immune status of middle and high school students in conditions of high blood content of a number of exogenous chemical impurities

Starkova

Dolgikh

Kazakova

2021

Hygiene and Sanitation

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Introduction. The quality of the habitat and increasing intensity of the educational load determine the negative changes of the health of schoolchildren, associated with a violation of immune mechanisms adaptation. Purpose. Study of features of the immune status of schoolchildren in the conditions of excessive hapten contamination by exogenous chemical factors. Materials and methods. Students who live in territories differing in the formation of excessive human-made chemical contamination (total 162 students) of senior and secondary education levels were examined. The analysis of contaminants in biological media utilizing gas chromatography method, high-performance liquid chromatography method, mass spectrometry method was performed. The state of cellular immunity was evaluated by the reaction of phagocytosis using formalinized ram erythrocytes and CD-immunogram parameters by flow cytometry. The state of humoral immunity identified with the production of serum immunoglobulins by radial immunodiffusion, as well as expression of specific antibodies to chemical factors by the method of allergosorbent testing. Results. We revealed an association of excess content of lead, nickel, formaldehyde, benzene, phenol in blood with deficiency phagocytic activity, imbalance of CD-subpopulations of immunocompetent cells characterized by the predominance of T lymphocytic activation (CD3+-lymphocytes), and a decrease in B-lymphocytes (CD19+-cells) both concerning the norm and to the group of schoolchildren with a permissible level of contaminating load. Secondary and senior students differed in imbalance of the immunoregulatory index CD4+/CD8+, and lower expression was revealed in high school students serum immunoglobulins IgM and IgA. In schoolchildren with excessive hapten contamination, there is a high level of sensitization to exogenous chemical factors according to the specific IgE antibodies to nickel, formaldehyde, and IgG to benzene, phenol, lead. Conclusion. The revealed imbalance of immune profile indices reflects the state of immunological health of schoolchildren, and the indices of cellular (immunoregulatory index CD4+/CD8+) and humoral (specific antihapten reagins) immunity, can be used as diagnostic for assessing the immune status in schoolchildren of secondary and senior levels of education in the conditions of excessive hapten contamination.

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Features of Immune Regulation and Apoptpsis Inchildren Under Industrial Exposure

Cited by 3 publications

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Some Aspects of Immune Status of Primary and Secondary Schoolchildren Living in Conditions of Technogenic Pollution of Urban Environment by Industrial Pollutants

Some Aspects of Immune Status of Primary and Secondary Schoolchildren Living in Conditions of Technogenic Pollution of Urban Environment by Industrial Pollutants

Hygienic Assessment of Ambient Air Pollution, Health Status and Laboratory Parameters of Workers and Residents of the Oil Production Area

Features of the immune status of middle and high school students in conditions of high blood content of a number of exogenous chemical impurities

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