Features of Inflammatory Response in Juvenile Depression with Attenuated Symptoms of Schizophrenic Spectrum

Zozulya, S A; Омельченко, М. А.; Sarmanova, Zoya; Migalina, V. V.; Каледа, В Г; Klyushnik, T. P.

doi:10.30629/2618-6667-2021-19-2-29-38

Psychiatry

2021

DOI: 10.30629/2618-6667-2021-19-2-29-38

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Features of Inflammatory Response in Juvenile Depression with Attenuated Symptoms of Schizophrenic Spectrum

S A Zozulya¹,

М. А. Омельченко²,

Zoya Sarmanova³

et al.

Abstract: РезюмеОбоснование: ранняя нозологическая квалификация юношеских депрессий и обнаружение в их структуре отдельных феноменов шизофренического спектра позволяет определить начало эндогенного процесса и осуществить своевременную терапевтическую интервенцию. Этому способствует комплексный подход, основанный на тщательной психопатологической оценке пациентов и определении индивидуальных иммунологических показателей крови. Цель: определение маркеров воспаления при юношеских депрессиях с аттенуированными симптомами ши… Show more

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2024

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Cited by 3 publications

References 19 publications

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Multifactorial, biomarker-based model for assessing the state of patients with schizophrenia

Cheremnykh,

Savushkina,

Prokhorova

et al. 2024

Bûll. sib. med.

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Relevance. Objective comparison of biological markers and real clinical presentation is especially difficult in mental disorders, which are classified according to a large number of diagnostic criteria and a wide variety of symptoms. Therefore, the development of an effective system of biochemical markers and assessment of their relationship to optimize the diagnosis and treatment of schizophrenia are relevant.The aim of the study was to develop a statistical model that combines known and tested biochemical markers for mental illnesses in patients with schizophrenia.Materials and methods. The study included 47 women aged 18–50 years (median age – 22 years) with the diagnosis of schizophrenia (ICD-10, F20) and 25 healthy women of the same age. The model was based on the functional activity of complement, thrombodynamics parameters, markers of inflammation, glutamate and energy metabolism, and antioxidant defense, which were shown to be associated with the severity of schizophrenia. The listed markers were evaluated in plasma, platelets, and erythrocytes of sick and healthy individuals.Results. Statistical software found pair correlations and features of the distribution of all markers as random variables in the examined groups and evaluated correlations between pairs of markers. Ten biomarkers were identified and united into a system that was adequately described by the logistic regression model. The model was evaluated using the Pearson’s test (χ2(11) = 57.6, p = 0.001) and calculation of correct predictions (91 and 80%) for samples of patients and healthy people, respectively.Conclusion. Calculating the logistic equation resulted in the probability that the patient has schizophrenia involving the immune system, hemostasis, and oxidative stress. This model can be considered as a new formalized approach to the preclinical diagnosis of mental illnesses.

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Multifactorial, biomarker-based model for assessing the state of patients with schizophrenia

Cheremnykh,

Savushkina,

Prokhorova

et al. 2024

Bûll. sib. med.

Self Cite

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Oxidative Stress in Schizophrenia: Relation to Neurochemical Pathogenetic Hypotheses

Burbaeva,

Prokhorova,

Savushkina

et al. 2024

Psychiatry

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Background: heterogeneity of schizophrenia is reflected in the variety of clinical manifestations and biological disorders, on the basis of which several neurochemical hypotheses are formulated for schizophrenia pathogenesis. Review of the current hypotheses of schizophrenia pathogenesis shows that oxidative stress is not the main cause of the disease development, but affects its course and contributes to the deterioration of the patient’s condition. Objective: analysis of the relationships between redox imbalance and oxidative stress and the development of pathological processes in schizophrenia within the framework of neurochemical hypotheses of the disease pathogenesis. Material and methods: a search was made for sources in the Medline/PubMed databases, Scopus and RSCI using keyword combinations “oxidative stress”, “oxidation-reduction imbalance”, “schizophrenia”, “hypotheses of schizophrenia pathogenesis”, “antioxidants”, “neurotransmitters”, “glutathione”, “neuroinflammation”. Conclusion: data from numerous studies of the brain of patients with schizophrenia, their blood plasma, serum, and blood cells as well as the study of animal models of schizophrenia indicate the presence of redox imbalance and oxidative stress in this disease. Taken together, these data indicate that genetic and environmental factors that affect the manifestation of various pathological mechanisms in schizophrenia (disturbances in neurotransmitter systems, hypofunction of N-methyl-D-aspartate receptors, neuroinflammation, impaired signaling protein phosphorylation pathways) lead to the oxidative stress, enhancing the initial pathological changes, as a result of which synchronization processes and intercellular communications in the brain become disrupted. Medicines with antioxidant and anti-inflammatory properties, compounds for correcting mitochondrial dysfunction, and NMDAR-mediated signaling modulators can be used as drugs to reduce the harmful effects of oxidative stress. The efficacy of these medicines may vary in different patients, so the development of biomarker systems aimed at identifying individuals who are more likely to respond to a particular drug is of great importance.

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Immunology of Schizophrenia: A Modern View on Inflammatory Hypotheses of the Disease

Klyushnik,

Zozulya

2024

Psychiatry

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Background: the immunological direction has always been a significant part of biological studies of schizophrenia and in different years has been based on the relevant fundamental ideas about the functions of the immune system and neuroimmune relationships. Objective: to conduct a brief historical analysis of immune hypotheses of schizophrenia, reflecting the vector of research of fundamental immunology, and also to present the results of our own research, confirming the key role of chronic inflammation in the pathogenesis of schizophrenia and the possibility of using immunological indicators for diagnosis and prognosis of the course of the disease. Materials and Method: using the keywords “schizophrenia”, “immune hypotheses of schizophrenia”, “neuroinflammation”, “neuroimmune relationships” we analyzed publications from PubMed/MEDLINE, RSCI databases and other sources of the last decades in comparison with the results of clinical and biological studies of schizophrenia at the Mental Health Research Centre (MHRC). Conclusion: based on the analysis of publications, it is shown that the development of scientfic ideas about the relationship between the immune system and schizophrenia has led to the understanding of the key role of chronic inflammation in the pathogenesis of this disease. Based on comparative studies of a number of immune markers related to cytokine system, acute phase proteins, proteolytic enzymes, etc., a laboratory test system “Neuroimmuno-test”, which includes complex determination of iflammatory and autoimmune markers in blood plasma, was created at the MHRC. It is shown that the level of immune system activation correlates with the features of psychopathological symptoms of patients. Identification of the immune profiles of patients is important to differentiate disease subtypes for the purpose of diagnosis and personalized therapy.

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Features of Inflammatory Response in Juvenile Depression with Attenuated Symptoms of Schizophrenic Spectrum

Cited by 3 publications

References 19 publications

Multifactorial, biomarker-based model for assessing the state of patients with schizophrenia

Multifactorial, biomarker-based model for assessing the state of patients with schizophrenia

Oxidative Stress in Schizophrenia: Relation to Neurochemical Pathogenetic Hypotheses

Immunology of Schizophrenia: A Modern View on Inflammatory Hypotheses of the Disease

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