Features of omental adipose tissue in endometrial cancer patients with ‘standard’ or ‘metabolically healthy’ obesity: associations with tumor process characteristics

Berstein, Lev M.; Iyevleva, Aglaya G.; Mukhina, Marina; Vasilyev, D. A.; Порошина, Т. Е.

doi:10.1186/s40064-016-3582-6

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…Interestingly, it has recently been reported that breast WAT from Black women, who have worse prognosis with breast cancer, have higher density of CLS-B than their non-Black counterparts (22). The probability that WAT inflammation helps to explain the obesity-inflammation-carcinogenesis axis is further supported by observations showing the occurrence of CLS in adipose tissue associated with other malignancies, including oral squamous cell carcinoma of the tongue (23), endometrial cancer (24), and in the report of liver macrophages, identified as Kupffer cells, forming CLS with lipidladen hepatocytes in NAFLD, a disorder now considered to be a precursor for hepatocellular cancer (14,25).…”

Section: Articles By Iyengar Et Al Published In This Issue Cancer Prsupporting

confidence: 52%

Crown-like Structures in Breast Adipose Tissue from Normal Weight Women: Important Impact

Berger

2017

Cancer Prevention Research

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Crown-like structures (CLS), composed of macrophages surrounding dead or dying adipocytes, are a histologic hallmark of the proinflammatory process by which adipose tissue contributes to the increased risk and worse prognosis of breast cancer in obese, postmenopausal patients. In this issue of Cancer Prevention Research, Iyengar and colleagues report the intriguing finding that CLS can be identified in a significant proportion of normal-BMI women undergoing mastectomy for breast cancer risk reduction or therapy. This surprising observation suggests that some normal weight women may have similar mechanisms driving initiation and/or progression of breast cancer as those contributing to the increased incidence and worse prognosis of breast cancer in obese postmenopausal women. The possibility of a common mechanism in both lean and obese women provides added impetus to more fully define this process and evaluate its important implications for prevention and screening strategies as well as therapeutic interventions. Cancer Prev Res; 10(4); 223-5. Ó2017AACR.

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Section: Articles By Iyengar Et Al Published In This Issue Cancer Prsupporting

confidence: 52%

Crown-like Structures in Breast Adipose Tissue from Normal Weight Women: Important Impact

Berger

2017

Cancer Prevention Research

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“…Peculiar histological structures, known as crown-like structures, characterized by dead or dying adipocytes surrounded by macrophages, are increased in the adipose tissue linked to obesity, and have been involved in the activation of nuclear factor-kB and the generation of a proinflammatory microenvironment. Concomitantly, they have been reported to play a role in the initiation and progression of endometrial cancer [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Leptin, Proinflammatory Cytokines and Oxidative Stress with Tumor Size and Disease Stage of Endometrioid (Type I) Endometrial Cancer and Review of the Underlying Mechanisms

Madeddu

Sanna

Gramignano³

et al. 2022

Cancers

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Endometrioid endometrial cancer is associated with increased BMI and obesity through multiple pathogenetic mechanisms involving hyperestrogenism, hyperinsulinemia, altered adipokine secretion, inflammation, and oxidative stress. In the present study, we aimed to investigate the correlation between BMI, leptin, the proinflammatory cytokines IL-6 and TNFα, reactive oxygen species (ROS), and the traditional prognostic factors T, G, N and M status among type I endometrioid and type II endometrial cancer patients. We enrolled 305 consecutive endometrial cancer patients prospectively. We found that BMI, leptin, and IL-6 significantly correlated with T status, N status, and M status among endometrioid type I endometrial cancer patients. Among type II endometrial cancer patients, BMI and leptin did not correlate with any of the prognostic parameters, whereas there was a positive correlation between IL-6 and the presence of distant metastases. In the multivariate regression analysis, BMI, leptin, and IL-6 were independent predictive variables of T, N, and M status in endometrioid type I endometrial cancer patients. Our study demonstrates that weight gain, adiposity-related adipokines, inflammation, and oxidative stress correlate with the prognostic factors of endometrioid endometrial cancer. Knowledge of the role of obesity-related biological pathways and mediators in the pathogenesis and prognosis of endometrioid endometrial malignancies may offer new perspectives on combined therapeutic strategies that have not been explored to date, both in the advanced disease and in the adjuvant setting.

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“…CLS are associated with free fatty acid (FFA) release, NF-κB activation and the generation of a proinflammatory microenvironment [ 106 ]. They are best characterized for their role in the initiation and progression of breast cancer [ 106 ] but they are also reported to play a role in endometrial cancer [ 107 ], prostate cancer [ 108 ] and non-alcoholic steatohepatitis (NASH)—a major risk factor for HCC [ 109 ]. In breast adipose tissue CLS are not only associated with inflammation but they also drive aromatase activity resulting in an increased ratio of estrogen:androgen in blood and local tissues [ 110 ].…”

Section: Mechanisms Linking Adipose Tissue To the Metastatic Cascamentioning

confidence: 99%

Obesity and Cancer Metastasis: Molecular and Translational Perspectives

Annett

Moore

Robson

2020

Cancers

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Obesity is a modern health problem that has reached pandemic proportions. It is an established risk factor for carcinogenesis, however, evidence for the contribution of adipose tissue to the metastatic behavior of tumors is also mounting. Over 90% of cancer mortality is attributed to metastasis and metastatic tumor cells must communicate with their microenvironment for survival. Many of the characteristics observed in obese adipose tissue strongly mirror the tumor microenvironment. Thus in the case of prostate, pancreatic and breast cancer and esophageal adenocarcinoma, which are all located in close anatomical proximity to an adipose tissue depot, the adjacent fat provides an ideal microenvironment to enhance tumor growth, progression and metastasis. Adipocytes provide adipokines, fatty acids and other soluble factors to tumor cells whilst immune cells infiltrate the tumor microenvironment. In addition, there are emerging studies on the role of the extracellular vesicles secreted from adipose tissue, and the extracellular matrix itself, as drivers of obesity-induced metastasis. In the present review, we discuss the major mechanisms responsible for the obesity–metastatic link. Furthermore, understanding these complex mechanisms will provide novel therapies to halt the tumor–adipose tissue crosstalk with the ultimate aim of inhibiting tumor progression and metastatic growth.

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Features of omental adipose tissue in endometrial cancer patients with ‘standard’ or ‘metabolically healthy’ obesity: associations with tumor process characteristics

Cited by 7 publications

References 43 publications

Crown-like Structures in Breast Adipose Tissue from Normal Weight Women: Important Impact

Crown-like Structures in Breast Adipose Tissue from Normal Weight Women: Important Impact

Correlation of Leptin, Proinflammatory Cytokines and Oxidative Stress with Tumor Size and Disease Stage of Endometrioid (Type I) Endometrial Cancer and Review of the Underlying Mechanisms

Obesity and Cancer Metastasis: Molecular and Translational Perspectives

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