Features of pigmented vulval lesions on dermoscopy

Ronger-Savlé, S.; Julien, V.; Duru, Gérard; Raudrant, D.; Dalle, S.; Thomas, Luc

doi:10.1111/j.1365-2133.2010.10043.x

Cited by 80 publications

(129 citation statements)

References 18 publications

(31 reference statements)

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“…Kadınlarda pigmente vulvar lezyonlar arasında vulvar melanomların görülme oranı son derece düşüktür. Tüm melanomların yalnızca %1-%3'ü, kadınlardaki melanomların ise %3-%7'si vulvar bölgeden kaynaklanmaktadır (4,6). Çalışmamızda hiç melanom tanısı alan hasta olmamıştır.…”

Section: Discussionunclassified

“…2) Melanosit hiperplazisi olmadan epitelyal hücrelerde artmış melanin pigmentine bağlı pigmentasyonlar epidermal hiperpigmentasyonlar olarak sınıflandırıldı (vulvar melanozis, postinflamatuar hiperplazi, liken simpleks kronikus gibi). 3) Melanosit veya melanin artışı olmadan pigmente görünüme sahip olan diğer lezyonlar ise nonmelanositik pigmente lezyonlar başlığı altında toplandı (anjiyokeratomlar, seboreik keratoz, kondiloma akuminata gibi) (6).…”

Section: Yöntemlerunclassified

“…Paralel, globuler, homojen/nonhomojen (yapısız patern), kaldırım taşı, retiküler benzeri, serebriform/ekzofitik yapılar ve yüzük benzeri yapılar olmak üzere yedi tip patern belirlendi (6)(7)(8). Paternlerin tanımlanması şu özelliklerine göre yapıldı:…”

Section: Dermoskopik Paternlerin Belirlenmesiunclassified

“…Vulvadaki pigmente lezyonların büyük çoğunluğu benign karakterdedir (6). Bununla birlikte, çoğu benign pigmente lezyon, irregüler ve atipik görünüm sergileyebilir, erken melanom veya vulvar intraepitelyal neoplazinin klinik özelliklerini gösterebilir.…”

Section: Introductionunclassified

“…Dermoskopi, pigmente deri lezyonlarının çoğunda faydalı, invaziv olmayan, standart bir tanı aracıdır (2). Vulvar pigmente lezyonların dermoskopik paternlerinin tanınması, hem gereksiz biyopsi ve eksizyon gibi invaziv işlemlerin azalmasına yardımcı olur hem de en uygun biyopsi yerinin belirlenmesi amacıyla kullanılabilir (6). Literatürde genellikle vulvar melanozis hakkında yapılmış dermoskopik araştırmalar görülmekle beraber, vulvayı etkileyen diğer pigmentasyonların karakteristik özellikleri konusunda çok az veri bulunmaktadır (7,8).…”

Section: Introductionunclassified

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Pigmente Vulvar Lezyonların Dermoskopi Özelliklerinin İncelenmesi

Emre¹,

Akoğlu²,

Metin³

et al. 2014

tdd

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Section: Discussionunclassified

Section: Yöntemlerunclassified

Section: Dermoskopik Paternlerin Belirlenmesiunclassified

Section: Introductionunclassified

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Pigmente Vulvar Lezyonların Dermoskopi Özelliklerinin İncelenmesi

Emre¹,

Akoğlu²,

Metin³

et al. 2014

tdd

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Dermoscopy of Pigmented Lesions of the Mucosa and the Mucocutaneous Junction

Blum

Simionescu

Argenziano³

et al. 2011

Arch Dermatol

112

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In Vivo Reflectance Confocal Microscopy for the Diagnosis of Melanoma and Melanotic Macules of the Lip

et al. 2017

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IMPORTANCE Benign melanotic macules (MAC) are the most frequent cause of lip pigmentation and sometimes difficult to differentiate from lip melanoma (MEL). OBJECTIVES To report in vivo reflectance confocal microscopy (RCM) features of normal lips of different phototypes and to identify features that assist in distinguishing MEL from MAC using dermoscopy and RCM. DESIGN, SETTING, AND PARTICIPANTS For this retrospective observational study, 2 groups of patients from 2 tertiary referral centers for melanoma (Sydney Melanoma Diagnostic Centre and Melanoma Institute Australia) were recruited between June 2007 and January 2015. Group 1 included patients with normal lips and different phototypes, and Group 2 consisted of patients with MAC and MEL; RCM and dermoscopy were used for lips analysis. MAIN OUTCOMES AND MEASURES Overall, 92 RCM features were correlated with clinical history, dermoscopic images, and histopathology in all patients with MEL and 5 patients with MAC. RESULTS Images from the vermillion and/or mucosal part of the lip were recorded from 10 patients with clinically normal lips (mean [SD] age, 34.5 [6.1] years), 16 patients with MAC (mean [SD] age, 49.6 [17.9] years), and 5 patients with 6 cases of MEL (1 patient had a recurrent lesion; mean [SD] age, 56.2 [15.5] years). In normal lips, the draped patterna previously described MAC RCM feature-was identified in all cases. In MEL, the following findings were frequent and significantly different from MAC: epidermal disarray; pagetoid infiltration of dendritic and/or round cells; a nonspecific architectural pattern at the dermoepidermal junction (DEJ); nonhomogenously distributed papillae; continuous (lentiginous) proliferation of cells with marked atypia at the DEJ, especially in interpapillary spaces; a higher number of dendritic cells (especially roundish); and atypical round cells at the DEJ. The cellular body area of dendritic cells was about the double in MEL compared with MAC. An RCM lip algorithm was developed that provided 100% sensitivity and 88% specificity for the diagnosis of MEL of the vermillion and mucosal part of the lip. With dermoscopy, MAC were correctly classified as benign in 13 of 16 cases (81%) and MEL were classified as equivocal or malignant in 5 of 6 cases (83%). CONCLUSIONS AND RELEVANCE Reflectance confocal microscopy can assist in the differential diagnosis of lip MEL and MAC. An RCM Lip Score that we developed based on study results is proposed and needs to be validated on an independent data set.

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Features of pigmented vulval lesions on dermoscopy

Cited by 80 publications

References 18 publications

Pigmente Vulvar Lezyonların Dermoskopi Özelliklerinin İncelenmesi

Pigmente Vulvar Lezyonların Dermoskopi Özelliklerinin İncelenmesi

Dermoscopy of Pigmented Lesions of the Mucosa and the Mucocutaneous Junction

In Vivo Reflectance Confocal Microscopy for the Diagnosis of Melanoma and Melanotic Macules of the Lip

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