Progress and methods used in positron based studies of inelastic atomic interactions are traced from the original discovery of the positron to the present. Following a historic overview and introduction, this review will show how new experimental techniques were critical in advancing experimental studies from total or integral cross section measurements to highly differential investigations that are now being performed. The primary emphasis is on ionization of atoms and simple molecules by low-energy (tens to hundreds of eV) positrons and in showing similarities and differences between positron, electron and proton impact data. Selected examples of Ps based studies are also included. Experimental techniques associated with the generation, moderation, and transport of low-energy positron beams plus an extensive reference list and tables summarizing existing experimental studies are provided. Comments with respect to future studies and directions, plus how they might be achieved, are presented.