Features of the Epidemiological Situation on Siberian Tick Typhus and other Tick-Borne Ricketsioses in the Russian Federation, Prognosis for 2019

Problemy Osobo Opasnykh Infektsii

Шпынов

Пеньевская

et al. 2020

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Objective of the study was to analyze the incidence of Siberian tick-borne typhus (STBT) in the Russian Federation between 2010 and 2019, Astrakhan spotted fever (ASF) and Mediterranean fever (MF) since official registration, and forecast the development of the epidemic process for endemic rickettsioses for 2020. Materials and methods. The analysis of the incidence of STBT, ASF and MF in the Russian Federation over the period of 2010–2019, 2013–2019 and 2014–2019, respectively, in relation to the results of zoological-entomological monitoring. Results and discussion. The average long-term incidence rate of STBT for 2010–2019 in the Russian Federation on the whole was 1.1 0 /0000 (DI95 1.05÷1.08) without trends towards change. The maximum relative incidence of STBT is typical for the Siberian Federal District (SFD) where the average long-term incidence rate for 2010–2019 amounted to 6.28 per 100 thousand of the population. In the second place is the Far Eastern Federal District (FEFD) – 5.17 0 /0000, in third – the Ural Federal District (UFD) – 0.1 0 /0000. When assessing the 10‑year dynamics of the relative incidence of STBT, we have revealed a significant tendency to increase in the FEFD, a tendency to stabilize in the SFD and a significant downward trend – in the UFD. A reliable increasing trend in STBT incidence was detected in the Altai Republic and in the Khabarovsk Territory. Major decline in STBT incidence was observed in the Trans-Baikal territory, Krasnoyarsk territory, Kurgan Region and the Republic of Khakassia. There is a marked tendency to increase in the incidence of MF in the Republic of Crimea. In the Astrakhan Region and the Republic of Kalmykia, there is an expressed tendency towards the reduction in the ASF morbidity rates.

Section: результаты и обсуждениеunclassified

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Epidemiological Situation on Tick-Borne Rickettsioses in the Russian Federation in 2010–2019 and Prognosis for 2020

Problemy Osobo Opasnykh Infektsii

Шпынов

Пеньевская

et al. 2020

Self Cite

“…В ДФО только в пяти из девяти субъектов ежегодно регистрируют заболеваемость СКТ. Средний уровень отмечен в Хабаровском крае (9,4 0 / 0000 ), Амурской области (6,1 0 / 0000 ) и Еврейской автономной области (7,5 0 / 0000 ), низкий уровень -в Республике Бурятия (2,5 0 / 0000 ), Забайкальском крае (2,3 0 / 0000 ) и Приморском крае (5,4…”

Section: материалы и методыunclassified

Long-term dynamics and epidemic intensity of Siberian tick typhus in federal districts and regions of Russian Federation during 2002-2018

Штрек

Fundamentalʹnaâ i kliničeskaâ medicina

Penjevskaya

et al. 2019

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Aim. To analyze epidemic intensity and long-term dynamics of Siberian tick typhus (STT) in Siberian and Far Eastern regions of Russian Federation.Materials and Methods. We analyzed STT incidence in different regions of Siberia and Far East during 2002-2018 utilising standardised data. Regions were further ranked according to incidence levels.Results. Cases of STT were regularly documented in 17 regions of Siberia and Far East. In six regions (Republic of Khakassia, Altai, Amur, Tyumen, Irkutsk, and Krasnoyarsk Region), a declining trend was revealed while in four regions there was a trend towards an increase in STT incidence (Republic of Tyva, Khabarovsk Region, Novosibirsk Region, and Omsk Region).Conclusion. The monitoring of STT foci and reservoirs natural foci in endemic areas in Central Asia is needed to predict the trends in STT incidence in Siberia and Far East.

Genotyping of rickettsias circulating in the territories of the Altai Republic and Khabarovsk krai

Штрек

Russian Journal of Infection and Immunity

Шпынов

et al. 2023

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The aim of the study was to verificate of the causative agent of Siberian tick-borne typhus (STT) upon ixodic tick mixed infection on the territory of the Altai Republic and Khabarovsk Krai using an integrated molecular biological approach. Materials and methods. The material for the study was presented as 304 imago of ixodic mites of six species. The ticks were collected on the territory of the Altai Republic and the Khabarovsk Krai in the years 20142022. Rickettsia DNA was identified by two-round PCR using genus- and species-specific primers for gltA and ompA genes, followed by sequencing and using PCR reagent kits RealBest DNA R. sibirica/R. heilongjiangensis (Vector-Best, Novosibirsk). Results. The detection of rickettsia in ticks in the Altai Republic was 82.6% (CI: 69.196.1), in the Khabarovsk Krai 53.1% (CI: 44.961.3). The species composition of rickettsias in various species of ixodic mites in these territories, endemic to Siberian tick typhus, is characterized by the presence of mixed forms. Rickettsia sibirica and R. raoultii were found in ticks Dermacentor nuttalli, Haemaphysalis concinna, D. silvarum. Only Candidatus R. tarasevichiae were detected in Ixodes persulcatus, I. pavlovsky mites and I. pavlovsky/persulcatus hybrids. The DNA of R. heilongjiangensis was found in H. mites. concinna in the Khabarovsk Krai. The DNA of Candidatus R. tarasevichiae is also present in the ticks of D. nuttalli and H. concinna from the Altai Republic. The DNA of the classic pathogenic species, R. sibirica, was detected in ticks D. nuttalli and H. concinna in the Altai Republic, ticks D. silvarum, H. concinna and H. japonica douglasi in the Khabarovsk Krai. In addition, in the Khabarovsk Krai, the DNA of R. heilongjiangensis was detected in H. concinna ticks, and a DNA fragment common to R. sibirica subsp. mongolitimonae and R. conorii was detected in H. japonica douglasi ticks, which requires further study. Candidatus R. tarasevichiae is common in Ixodes mites (I. persulcatus, I. pavlovsky and their hybrids), in the Altai Republic in D. nuttalli and H. concinna. R mites. raoultii was detected in ticks of the genus Dermacentor D. nuttalli in the Altai Republic and D. silvarum in the Khabarovsk Krai. Conclusions. During molecular biological monitoring of rickettsias in endemic territories, the detection of R. raoultii masks the presence of the etiological agent of STT R. sibirica. This phenomenon makes it possible to explain the high incidence of STT in the studied territories, with the rare detectability of R. sibirica DNA during molecular biological screening in ixodic mites.