2019
DOI: 10.1016/j.seizure.2018.12.004
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Febrile seizures: Are they truly benign? Longitudinal analysis of risk factors and future risk of afebrile epileptic seizure based on the national sample cohort in South Korea, 2002–2013

Abstract: We performed a large, population-based study to analyze the risk factors of the febrile seizures and the subsequent afebrile epileptic seizures. Methods: Relevant data from children born between 2002-2007 were retrieved from the Korean National Health Insurance Service-National Sample Cohort 2002-2013. Children who did not survive the first five years were excluded from the analysis. The risk factors for febrile seizures were assessed separately in per-person and perfebrile case analyses, and factors contribut… Show more

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Cited by 26 publications
(20 citation statements)
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“… 24 The rate in South Korea is also high, at 11.2% in children aged up to 5 years. 11 In contrast, the prevalence rate of febrile seizure is 2.3% in the UK, 10 3.4% in the USA, 6 4.3% in Turkey, 15 4.9% in Denmark, 22 6.9% in Finland 25 and 10.1% in India. 27 These geographical differences are attributed mainly to the racial and genetic factors.…”
Section: Discussionmentioning
confidence: 97%
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“… 24 The rate in South Korea is also high, at 11.2% in children aged up to 5 years. 11 In contrast, the prevalence rate of febrile seizure is 2.3% in the UK, 10 3.4% in the USA, 6 4.3% in Turkey, 15 4.9% in Denmark, 22 6.9% in Finland 25 and 10.1% in India. 27 These geographical differences are attributed mainly to the racial and genetic factors.…”
Section: Discussionmentioning
confidence: 97%
“…We were also unable to identify the lifetime prevalence of febrile seizures. Most previous studies included children aged up to 5 years 10 11 22 24 25 27 ; however, our study only included children aged up to 3 years, similar to a few Japanese studies. 7 21 Therefore, the lifetime prevalence of febrile seizures in Japan might be higher than that in our study.…”
Section: Discussionmentioning
confidence: 99%
“…The incidence seems to be higher in some eastern European populations (8-10% incidence). 5 Up to 90% of children with SFS have experienced a convulsive event before the age of 3 years, with the peak incidence occurring between ages 18 and 24 months. In addition, only 6% of children experience a seizure before 6 months and 4% after 3 years.…”
Section: Epidemiology and Pathophysiologymentioning
confidence: 99%
“…The most important predictive risk factors for the development of epilepsy are developmental delay, abnormal neurological exam prior to the febrile seizure, history of complex febrile seizures or febrile status epilepticus, and a first degree relative with epilepsy. 5,9,34 The exact mechanism for development of epilepsy is complex and not fully elucidated. These risk factors may suggest a preexisting predisposition to develop epilepsy.…”
Section: Risk Factors For Recurrence Of Febrile Seizuresmentioning
confidence: 99%
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