Febrile Transfusion Reactions Reduced by Use of Buffy‐Coat‐Poor Erythrocyte Concentrates

Liedén, Gudrun; Hildén, Jan‐Olof

doi:10.1111/j.1423-0410.1982.tb00023.x

Cited by 58 publications

(18 citation statements)

References 7 publications

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“…This was in concordance with Callera et al, [7] who observed 64.2% with packed cells and 25% with platelet transfusion. Febrile reactions result from the interaction of the recipient antibodies with the antigens on donor leucocytes and can be reduced by transfusion of leuco-reduced blood products [18][19][20]. Commonest reaction noted with fresh frozen plasma by us and the Brazilian study [12] was allergic.…”

Section: Methodsmentioning

confidence: 99%

Acute Transfusion Reactions (ATRs) in Intensive Care Unit (ICU): A Retrospective Study

Kumar

Gupta

et al. 2014

JCDR

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Section: Methodsmentioning

confidence: 99%

Acute Transfusion Reactions (ATRs) in Intensive Care Unit (ICU): A Retrospective Study

Kumar

Gupta

et al. 2014

JCDR

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“…Hence, WBC removal from the transfused products has proven to be beneficial to patients in preventing many of these adverse reactions [3, 7, 8, 9, 10], and it was recommended in the Council of Europe Guidelines that the number of white cells should be reduced to <1 × 10 6 /unit in 90% of transfusion units [11]. …”

Section: Introductionmentioning

confidence: 99%

White Blood Cell Subsets in Buffy Coat-Derived Platelet Concentrates: The Effect of Pre- and Poststorage Filtration

Ledent¹,

Semple²,

Berlin³

2000

Vox Sanguinis

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Background and Objectives: Our objective was to study the effect of storage time on the filtration of platelet concentrates (PCs). We compared the total number of white blood cells (WBC), as well as the distribution of WBC subsets, in units filtered before and after storage. Materials and Methods: Buffy coat-derived PCs were filtered either fresh or after 5 days of storage, and total WBC were enumerated by flow cytometry. WBC subsets were analyzed by flow cytometry with three-color fluorescence. Results: The total number of white cells before filtration was significantly higher in fresh units compared with stored units, whereas in postfiltration samples the number of white cells was significantly lower in the fresh compared with the stored units. Although absolute numbers were significantly reduced, filtration also induced significant changes in the proportions of subsets in both fresh and stored units; the percentage of T cells was decreased, whereas the percentage of B cells and monocytes was increased after filtration. Conclusion: Our results suggest that prestorage WBC filtration of platelet concentrates is superior in reducing the absolute numbers of WBC. However, both pre- and poststorage WBC filtration significantly affect the proportions of WBC in the final product, decreasing the number of T cells while apparently increasing the proportion of MHC class II-positive cell populations.

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“…Removal of leucocytes in blood components reduces transfusion complications characterised by febrile reactions [1], immune modulation [2], induction of refractoriness to transfused platelets [3]and transfusion-transmitted cell-associated viruses such as cytomegalovirus [4]. Routinely used, high-efficiency leucocyte depleting filters can remove more than 99.9% of leucocytes from erythrocyte and platelet concentrates [5].…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Bradykinin Levels during and after Leucocyte Filtration of Platelet& ;Concentrates

et al. 1998

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Objective: To measure beadykinin levels in platelet concentrates during and after leucocyte filtration. Methods: Platelet concentrates were leukocyte depleted using three different leucocyte-depletion filters selected to represent filters with negative, positive or neutral charge, respectively. Bradykinin levels were analysed before, during and up to 90 min post-filtration. Results: Significant levels of bradykinin were generated when negatively charged leucocyte depletion filters were used. However, we found a high variation between platelet concentrates prepared from different donors as well as within the same concentrate when this was divided into three aliquots. Generated bradykinin was rapidly degraded in the collection bag and no bradykinin was detectable 60 min post-filtration. Conclusion: Bradykinin generation is more pronounced when negatively charged leucocyte removal filters are used. Due to a rapid degradation of bradykinin in the storage bag, pre-storage filtration should minimise the risk of bradykinin related adverse reactions during transfusion with some filters.

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Febrile Transfusion Reactions Reduced by Use of Buffy‐Coat‐Poor Erythrocyte Concentrates

Abstract: In a medium-sized Swedish hospital there was a switch on a certain date from unprepared whole blood to buffy-coat-poor concentrates in all erythrocyte transfusions. The incidence of febrile transfusion reactions decreased by half.

Cited by 58 publications

References 7 publications

Acute Transfusion Reactions (ATRs) in Intensive Care Unit (ICU): A Retrospective Study

Acute Transfusion Reactions (ATRs) in Intensive Care Unit (ICU): A Retrospective Study

White Blood Cell Subsets in Buffy Coat-Derived Platelet Concentrates: The Effect of Pre- and Poststorage Filtration

Kinetics of Bradykinin Levels during and after Leucocyte Filtration of Platelet& ;Concentrates

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