Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up

Mahdipour, Mahsa; Shafaghi, Afshin; Mansour-Ghanaei, Fariborz; Hojati, Amineh; Joukar, Farahnaz; Mavaddati, Sara

doi:10.1016/j.jcol.2018.10.012

Cited by 3 publications

(4 citation statements)

References 38 publications

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“…Common endoscopic findings include erythema, friable mucosa, pseudo-polyps, and continuous lesions. Fecal calprotectin (FC) levels are known to be related to the disease severity in UC patients [14]. Alternative non-invasive methods such as an FC assay could prevent aggressive testing such as colonoscopy and biopsy, possibly helping improve the patient's quality of life [14].…”

Section: Discussionmentioning

confidence: 99%

“…Fecal calprotectin (FC) levels are known to be related to the disease severity in UC patients [14]. Alternative non-invasive methods such as an FC assay could prevent aggressive testing such as colonoscopy and biopsy, possibly helping improve the patient's quality of life [14]. Fecal lactoferrin (FL) is secreted by neutrophils in the inflamed intestine [15].…”

Section: Discussionmentioning

confidence: 99%

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An Atypical Case of Yersinia enterocolitica Infection in a Patient Suspected With Ulcerative Colitis Flare-Up

Doshi,

Sivaram,

Sievers

2024

Cureus

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Ulcerative colitis (UC), one of the two major inflammatory bowel diseases (IBD), is a chronic immunemediated inflammatory disorder with varying degrees of colonic mucosal involvement. Patients often present with inflammation limited to the rectum, also known as ulcerative proctitis, proximal colonic involvement, or pancolitis which affects the entire colon. Clinical manifestations of UC flare-ups include hematochezia, diarrhea, and abdominal pain. Yersinia enterocolitica, an acute cause of infectious diarrhea, is usually caused by the ingestion of food products contaminated with toxins and pathogens. The most common clinical presentation of a patient with acute Y. enterocolitica infection is self-limiting gastroenteritis. Microbial properties such as tissue invasion and immunological capability may be associated with the development of chronic conditions such as UC. IBD has been extensively studied, but the interrelationship between IBD and infectious causes of diarrhea is still up for debate. We present a case of atypical Y. enterocolitica infection with a long-standing history of UC that was initially misdiagnosed as an acute UC flare-up.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An Atypical Case of Yersinia enterocolitica Infection in a Patient Suspected With Ulcerative Colitis Flare-Up

Doshi,

Sivaram,

Sievers

2024

Cureus

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“…Immunological pathophysiology of IBD IBD is a chronic disorder marked by periods of remission and symptom exacerbation. IBD comprises Crohn's disease (CD), which can affect any part of the gastrointestinal tract, and ulcerative colitis (UC), primarily occurring in the rectum, ascending colon, or both (Mahdipour et al, 2019). Globally, IBD exhibits a widespread presence, with a consistent occurrence in developed regions such as Western Europe, the United States, and Canada, and a significant rise in incidence and prevalence in newly industrialized regions (Kaplan et al, 2019).…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

MARTINS,

ALVES,

ARAÚJO

et al. 2023

BIOCELL

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Curcumin, a natural product, has exhibited promising effects in both animal models and clinical trials, interacting with a multitude of factors linked to Inflammatory Bowel Disease (IBD). These factors encompass cytokines, oxidative stress-associated enzymes, and modulation of the intestinal microbiota. Notably, curcumin has demonstrated therapeutic potential in animal models of colitis, wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, and β-catenin. Moreover, it inhibits the expression of proinflammatory enzymes and co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating the characteristic neutrophil infiltration observed in IBD. Another facet of curcumin's action involves its modulation of the intestinal microbiota. Notably, the microbiota itself contributes to beneficial biotrans formations of curcumin, thereby enhancing its effectiveness in IBD treatment. On a clinical front, curcumin has demonstrated the ability to induce clinical and/or endoscopic remission without any reported toxic effects. Hence, curcumin warrants consideration as an adjunctive therapy in IBD management. Subsequent clinical investigations should concentrate on meticulously evaluating curcumin's impact on these precise therapeutic targets.

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“…Fecal calprotectin has been studied as a sole biomarker in UC with good results [ 11 ]; however, it leaves room for improvement in terms of performance metrics.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Calprotectin’s Predictive Power as a Biomarker of Endoscopic Activity in Ulcerative Colitis: A Machine Learning Use Case

Dranga,

Mihai,

Gavrilescu

et al. 2024

Biomedicines

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Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by periods of exacerbation and remission, making disease monitoring and management challenging. Endoscopy, the gold standard for assessing disease activity and severity, involves invasive procedures and is associated with patient discomfort and risks. Using machine learning (ML) to combine fecal calprotectin with other clinical or biological tests can significantly enhance the non-invasive prediction of endoscopic disease activity (EDA) in UC. Aim: To prove that by fusing fecal calprotectin with other clinical data into an ML model, the performance of the non-invasive prediction of EDA can be significantly improved. Methods: We conducted a prospective, observational, single-center study encompassing 103 patients diagnosed with UC. We employed multilayer perceptron models as the core ML algorithm for predicting EDA. For the constructed models, we utilized the varImp function from the caret library in R to assess the significance of each variable in predicting the outcome. Results: Calprotectin as a sole predictor obtained an accuracy of 70% and an area under the curve (AUC) of 0.68. Combining calprotectin with the list of selected predictors that were fed to the MLP models improved accuracy and the AUC. The accuracy of the algorithm on the test set was 85%. Similarly, the AUC increased to 0.93. This is the first study to propose the use of calprotectin as a predictor in an ML model to estimate UC endoscopic disease activity. Conclusion: The deployment of this ML model can furnish doctors and patients with valuable evaluation of endoscopic disease activity which can be highly beneficial for individuals with UC who need long-term treatment.

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Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up

Cited by 3 publications

References 38 publications

An Atypical Case of Yersinia enterocolitica Infection in a Patient Suspected With Ulcerative Colitis Flare-Up

An Atypical Case of Yersinia enterocolitica Infection in a Patient Suspected With Ulcerative Colitis Flare-Up

Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

Enhancing Calprotectin’s Predictive Power as a Biomarker of Endoscopic Activity in Ulcerative Colitis: A Machine Learning Use Case

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