Fecal microbiota transplantation relieve painful diabetic neuropathy

Abstract

Rationale:Fecal microbiota transplantation (FMT) has been used in a wide variety of diseases. In this article, we reported a 46-year-old female with diabetic neuropathy (DN) achieved remission by the treatment of FMT.Patient concerns:The patient with an 8-year history of diabetes and hypertension was admitted to hospital due to sensitive pain of her right thigh and poor blood glucose control. The traditional hypoglycemic and analgesic treatment were useless to her symptoms.Diagnosis:Diabetic-induced neuropathy was considered.Interventions:This patient received twice FMTs for 3 months.Outcomes:After twice FMTs, the clinical response of patient was pleasant. The glycemic control was improved, with a remarkable relief of the symptoms of painful DN in particular. No obvious adverse effects were observed during the FMTs and follow-up observation-testing.Lessons:We proposed that FMT could be a promising treatment in patients with diabetes or diabetes-related complications like DN. FMT also appeared to be definitely safer and more tolerable than the pharmacologic treatment in patients with DN.

Fecal Microbiota Transplantation in Neurological Disorders

“…Furthermore, fasting blood glucose levels decreased and stabilized, and HbA1c decreased from 7.5 to 6.3. However, length of follow-up was unclear and therefore it is unknown how long the improvements lasted (Cai et al, 2018).…”

Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain

“…A case study [ 64 ] of a woman with type 2 diabetes mellitus and diabetic neuropathy showed that two rounds of FMT improved limb pain and paresthesia, which was manifested as decreased visual analogue pain score (VAS) and increased tibial nerve motor conduction velocity, without any significant improvement in EMG sensory dysfunction. In addition, the fasting blood glucose level also decreased and stabilized, and glycosylated hemoglobin content decreased post-FMT.…”

Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation

“…FMT is used mainly for the treatment of recurrent Clostridium difficile infection (rCDI) [20,21]. Except for rCDI, FMT was used to treat inflammatory bowel diseases (IBD) [22], diabetes mellitus [23], autistic spectrum disorders [24], obesity [16,25], and also to reduce symptoms of chronic intestinal pseudo-obstruction syndrome (CIPO) or small intestinal bacterial overgrowth syndrome (SIBO) [26,27]. SIBO is a digestive disorder with an increased count and/or abnormal spectrum of the small intestinal microbial population associated with different health conditions (e.g.…”