Fecal pyruvate kinase: A potential new marker for intestinal inflammation in children with inflammatory bowel disease

Czub, Elzbieta; Herzig, Karl‐Heinz; Szaflarska-Popawska, Anna; Kiehne, Karlheinz; Socha, Piotr; Woś, Halina; Kamińska, Barbara; Błaszczyński, Michał; Cichy, Wojciech; Bała, Grażyna; Brodzicki, Jacek; Grzybowska-Chłebowczyk, Urszula; Walkowiak, Jarosław

doi:10.1080/00365520701320513

Cited by 37 publications

(37 citation statements)

References 15 publications

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“…Czub and colleagues demonstrated that the dimeric isoform of pyruvate kinase (PK) detected in the stool of children suffering from inflammatory bowel disease (IBD) might serve as a potential non-invasive screening tool for inflamed pouch mucosa. 42 Enzyme immunoreactivity was found to be significantly higher in all IBD patients than in healthy subjects. 42 Lower activity of plasma PK of autistic children could therefore be inversely related to the higher fecal level.…”

Section: Disclosuresmentioning

confidence: 99%

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Activities of key glycolytic enzymes in the plasma of Saudi autistic patients

El‐Ansary¹

2010

OAJCT

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Objective: Measurement of plasma levels of lactate, lactate oxidase (LOX), pyruvate kinase (PK), and hexokinase (HK) as possible glycolytic parameters to assess brain damage in autistic patients. Design and methods: Plasmatic levels of lactate, LOX, PK, and HK were determined in 20 autistic children aged 3-15 years and 20 age-matching healthy control subjects. Results: Plasmatic levels of lactate and LOX were significantly higher in autistic patients compared to healthy subjects and that of PK and HK were significantly lower in these patients as compared to controls. This could reflect the impaired metabolism of astrocytes, the brain cells responsible for the production and provision of lactate, as the primary metabolic fuel for neurons. Conclusion: Remarkably different levels of plasma glycolytic parameters were recorded in Saudi autistic patients. This could be correlated to the impairment of energy metabolism, glutathione depletion, and lead intoxication previously detected in the same investigated samples. The identification of biochemical markers related to autism would be advantageous for earlier clinical diagnosis and intervention.

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Section: Disclosuresmentioning

confidence: 99%

“…42 Enzyme immunoreactivity was found to be significantly higher in all IBD patients than in healthy subjects. 42 Lower activity of plasma PK of autistic children could therefore be inversely related to the higher fecal level.…”

Section: Disclosuresmentioning

confidence: 99%

Activities of key glycolytic enzymes in the plasma of Saudi autistic patients

El‐Ansary¹

2010

OAJCT

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“…16 The aim of this study was therefore to investigate measurement of fecal M2-PK in the differentiation of functional and organic bowel disorders.…”

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confidence: 99%

Fecal dimeric M2-pyruvate kinase (tumor M2-PK) in the differential diagnosis of functional and organic bowel disorders

Jeffery

Lewis

Ayling

2009

Inflammatory Bowel Diseases

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“…Low M 2 -PK expression could potentially mean flare-up resolution. Czub et al 52 reported abnormal M 2 -PK levels in 49 of 75 UC patients and in 27 of 32 CD patients. Though in later studies, they were not able to demonstrate superiority in differentiating disease severity and remission compared with FC.…”

Section: A Marker Of Inflammatory Bowel Diseasementioning

confidence: 99%

Calprotectin: Clinical Applications in Pediatrics

Herrera

Christensen

Helms

2016

The Journal of Pediatric Pharmacology and Therapeutics

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As seen over the past 20 years, calprotectin has evolved as a novel, non-invasive biomarker of gastrointestinal (GI) inflammation. We present this review of calprotectin in pediatrics. This article will focus on studies using calprotectin concentrations from different body fluids to monitor inflammation in different disease states and conditions. The ultimate goal of our group is to lay down a foundation as we consider using calprotectin prospectively as a marker of intestinal inflammation that could lead to further testing and possibly a marker of preparedness for feeding. We surveyed all published studies in English of calprotectin in neonates, infants, children, and adolescents through February 2014. We will discuss calprotectin's basic properties and analysis such as characteristics, identification, presence in body fluids, and maturational development. In addition, calprotectin's use in inflammatory diseases exploring both GI and non-GI conditions will be evaluated and compared with other serum markers presently available. Finally, a summary of our findings and discussion of future work that could be undertaken in order to render calprotectin as a more useful monitoring tool to the medical research community will complete the review.

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Fecal pyruvate kinase: A potential new marker for intestinal inflammation in children with inflammatory bowel disease

Abstract: The measurement of stool PK could be a potentially useful marker of IBD activity in children. However, its clinical value demands further studies for comparison with other tests.

Cited by 37 publications

References 15 publications

Activities of key glycolytic enzymes in the plasma of Saudi autistic patients

Activities of key glycolytic enzymes in the plasma of Saudi autistic patients

Fecal dimeric M2-pyruvate kinase (tumor M2-PK) in the differential diagnosis of functional and organic bowel disorders

Calprotectin: Clinical Applications in Pediatrics

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