FeCl₂-Catalyzed Oxidative Amidation of Aldehydes with Primary and Secondary Amines

Abstract

The amidation reaction is an important process in both academia and industry for the synthesis of natural products, functional polymers, and pharmaceuticals. The development of new amidation methods for constructing such important class of organic compounds is still attracting considerable interests. We herein reported a general oxidative amidation of aldehydes with a variety of free primary or secondary amines using inexpensive iron(II) chloride as catalyst and tert-butyl hydroperoxide (TBHP) as oxidant. The present amidation reactions afford the corresponding secondary and tertiary amides in moderate to excellent yields. In addition, the amidations of benzimidazole and pyrazole were also achieved by the developed method.

An Industrial Scale Synthesis of Adipicdihydrazide (ADH)/Polyacrylate Hybrid with Excellent Formaldehyde Degradation Performance

“…Formaldehyde is consumed during the reaction and free formaldehyde in the air is thus reduced. Primary amines are first targeted by alpha-hydrogen on the formaldehyde molecule and then secondary amines, as primary amines are more active than secondary amines [37,38]. One molecule of water is removed and a carbon-nitrogen double bond functional group is formed (as shown in Figure 6).…”