Based on empirical quantitative data, the article provides a comparative analysis of existing studies of the policy of countering COVID-19 infection in selected European Union countries and Russia, the specifics of restrictive governmental measures (including institutional dimension), and also provides a quantitative analysis of the relationship between the severity of epidemiological situation in a particular country, the stringency of governmental response measures, and the institutional characteristics of the country (including the quality of healthcare, management, the level of public trust in the government, value orientations, etc.), which determine the specifics of measures taken and their effectiveness. Using the developed index of the severity of the epidemiological situation, institutional characteristics that most affect the effectiveness of the measures applied and, if possible, allow combining the relatively easy passage of the pandemic with relatively lax measures were identified.