Feed‐control development for succinic acid production with <i>Anaerobiospirillum succiniciproducens</i>

Bretz, Karlheinz; Kabasci, Stephan

doi:10.1002/bit.24387

Cited by 27 publications

(24 citation statements)

References 70 publications

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“…Chen and colleagues enhanced the succinic acid concentration from 15.5 g L −1 to 23.4 g L −1 at the yield of 11.5 g per 100 g dry matter and productivity from 0.22 to 0.33 g L −1 h −1 by utilizing the fed‐batch SSF procedure from rapeseed meal by A. succinogenes strain. In addition, Bretz and Kabasci increased the succinate production yield by An. succiniciproducens from 0.60 to 0.88 g g −1 glucose during fed‐batch fermentation in comparison with the batch process performed with similar glucose concentrations.…”

Section: Discussioncontrasting

confidence: 77%

High production yield and specific productivity of succinate from cassava starch by metabolically-engineeredEscherichia coliKJ122

Khor

Sawisit

Chan

et al. 2016

J. Chem. Technol. Biotechnol.

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BACKGROUND Succinate has been widely used in chemical industries and its microbial production is a desirable option. The feasibility of bio‐based succinate production on an industrial scale strongly depends on the utilization of cheaper renewable resources. The use of cassava starch may make the fermentation process of succinate more economically competitive. RESULTS Simultaneous saccharification and fermentation (SSF) of succinate production was performed in minimal salt medium containing a cheap cassava starch. The parameters affecting succinate production from cassava starch by E. coli KJ122 were optimized. A succinate concentration of 70.1 ± 0.1 g Ll−1 was produced with a yield of 1.00 ± 0.01 g g−1 substrate and productivity of 0.97 ± 0.01 g L−1h−1 during batch SSF in a 2 L fermentor under optimized conditions. Further improvements in succinate concentration (82.5 ± 0.7 g L−1), yield (1.03 ± 0.01 g g−1 glucose), and average and specific productivities of 1.15 ± 0.01 g L−1h−1, and 456 mg g CDW−1 h−1, respectively, were observed in fed‐batch SSF. CONCLUSION Escherichia coli KJ122 produced a succinate yield of 92% of theoretical maximum and the highest specific productivity ever reported. Succinate production yield and specific productivity from cassava starch in this study are superior to other previously published works. Escherichia coli KJ122 may be used as a biocatalyst for cost‐effective succinate production. © 2016 Society of Chemical Industry

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Section: Discussioncontrasting

confidence: 77%

High production yield and specific productivity of succinate from cassava starch by metabolically-engineeredEscherichia coliKJ122

Khor

Sawisit

Chan

et al. 2016

J. Chem. Technol. Biotechnol.

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“…As the primary goal of fermentation research is cost‐effective production of bioproducts, it is important to develop a cultivation method that allows production of the desired product at high concentration with high productivity and yield . Fed‐batch culture has been widely used for the production of various bioproducts, including primary and secondary metabolites, proteins, and other biopolymers, as well as to prevent or reduce substrate‐associated growth inhibition by controlling nutrient supply . In the present study, we utilized a fed‐batch strategy in MECs to prevent the inhibitory effect of high concentration of molasses on succinic acid production (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…34 Fed-batch culture has been widely used for the production of various bioproducts, including primary and secondary metabolites, proteins, and other biopolymers, as well as to prevent or reduce substrate-associated growth inhibition by controlling nutrient supply. 35 In the present study, we utilized a fed-batch strategy in MECs to prevent the inhibitory effect of high concentration of molasses on succinic acid production ( Fig. 4).…”

Section: Effects Of Fed-batch Fermentation Of Molasses On Succinic Acmentioning

confidence: 99%

Enhanced succinic acid production from polyacrylamide‐pretreated cane molasses in microbial electrolysis cells

Wang

Jiao

et al. 2017

J of Chemical Tech & Biotech

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BACKGROUND Microbial electrolysis cells (MECs) are bioelectrochemical reactors in which chemical energy stored in organic compounds is converted to hydrogen through biocatalytic oxidation by microorganisms. This study is the first to report on the practical application of an electric MEC bioreactor to succinic acid anaerobic fed‐batch fermentation from polyacrylamide‐pretreated cane molasses by Actinobacillus succinogenes (130Z). RESULTS When molasses was used as the carbon source with an initial sugar concentration of 15 g L‐1, the succinic acid concentration was 22.4% higher in electric MECs than in non‐electric MECs. However, the high molasses concentration inhibited the function of MECs. Nevertheless, anionic polyacrylamide (APAM) pretreatment of molasses was noted to be effective for succinic acid production in MECs even at an initial sugar concentration of 75 g L‐1. Therefore, fed‐batch fermentation of APAM‐pretreated cane molasses with electric MECs at −1.0 V was performed, and a succinic acid concentration of 83.67 g L‐1 and productivity of 1.743 g L‐1 h‐1 were obtained, which were 20.7% and 505% higher than those achieved in non‐electric MECs and without pretreated molasses in MECs, respectively. CONCLUSION The succinic acid concentration is significantly increased in electric MECs. Polyacrylamide treatment strategy can resolve the inhibition of high molasses concentration to succinic acid production in MECs and might be an effective method for improvement of chemical production from high hydrolysate content using MECs. Fed‐batch fermentation with polyacrylamide‐pretreated cane molasses in electric MECs is noted to be ideal to achieve further increase in succinic acid concentration and yield. © 2017 Society of Chemical Industry

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“…Succinic acid can be produced from carbohydrates through fermentation, using Anaerobiospirillum succiniciproducens [26][27][28][29][30][31]. During the fermentation process, CO 2 is consumed, contributing to carbon sequestration [32].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of poly(butylene succinate) using metal catalysts

et al. 2014

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Feed‐control development for succinic acid production with Anaerobiospirillum succiniciproducens

Cited by 27 publications

References 70 publications

High production yield and specific productivity of succinate from cassava starch by metabolically-engineeredEscherichia coliKJ122

High production yield and specific productivity of succinate from cassava starch by metabolically-engineeredEscherichia coliKJ122

Enhanced succinic acid production from polyacrylamide‐pretreated cane molasses in microbial electrolysis cells

Synthesis of poly(butylene succinate) using metal catalysts

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