Feedback control of thirst in rats

Feider, Allen

doi:10.1016/0031-9384(72)90188-6

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…Oral and gastric mechanisms. The necessity of gastric preabsorptive satiety mechanisms has been questioned by Hatton andBennett (1970) andFeider (1972). The data presented here are in general agreement with their findings in demonstrating rapid absorption and by indicating that gastric volumes never become impressively large during rehydration.…”

Section: Discussionsupporting

confidence: 87%

“…The cecum and colon are engorged with fluid by 1 hr, which may help account for the diarrhea commonly observed in rats drinking saline. The development of intestinal pathology within 1 hr of the initiation of drinking underscores the lack of orogastric inhibition in rats drinking isotonic saline and is in complete accord with Feider's (1972) conclusions insofar as the failure of intragastric isotonic saline to inhibit drinking is concerned.…”

Section: Physiologicalsupporting

confidence: 65%

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Orogastric, hydrational, and behavioral controls of drinking following water deprivation in rats.

Hall¹,

Blass²

1975

Journal of Comparative and Physiological Psychology

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Drinking and its associated behaviors were studied in rats deprived of fluid for 8, 24, or 48 hr. The behavior of rats drinking water could be divided into into three successive stages: (a) an initial intense burst of drinking that could not be easily disrupted; (b) intermittent drinking, often distinguished by the brief appearance of conflict behavior directed at the drinking spout; and (c) termination of drinking. Drinking stopped well before the fluid loss, reflected in a sizable extracellular deficit, was restored. Intake of water was terminated when serum hyponatremia and hypoosmolality (and presumably cellular overhydration) developed in temporal continguity with drinking. These and other considerations suggest that the cellular fluid phase exerts significant inhibitory as well as excitatory control over drinking.

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Section: Discussionsupporting

confidence: 87%

Section: Physiologicalsupporting

confidence: 65%

Orogastric, hydrational, and behavioral controls of drinking following water deprivation in rats.

Hall¹,

Blass²

1975

Journal of Comparative and Physiological Psychology

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“…An adult rat given a gastric load of hypertonic saline solution responds with an increase in water intake (Feider, 1972). In the case of the adult rats studied by Feider, the extracellular osmolality can be estimated to have risen by about 136 milliosmoles/kg H 2 0 following a gastric load of 15 ml.…”

Section: Discussionmentioning

confidence: 99%

Effects of gastric loads and food deprivation on subsequent food intake in suckling rats.

Houpt¹,

Houpt²

1975

Journal of Comparative and Physiological Psychology

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Suckling rats were subjected to deprivation periods of 6-8 hr. Intake following deprivation was greater in deprived than in nondeprived sucklings, but did not increase with increasing deprivation. Gastric loads of NaCl solutions depressed subsequent intake; 3% NaCl was more effective than .9% NaCl. Other gastric loads of varying osmotic and caloric value also depressed subsequent intake. In order of increasing effectiveness in depressing intake, the gastric* loads were protein hydrolystate, heavy cream, water, milk, lactose, glucose, and corn oil. Effectiveness was unrelated to osmotic or caloric value of the load. Gastric fill and, possibly, some property of carbohydrate appear to be important determinants of satiety in the suckling rat.The controls of food intake in the neonate have drawn considerable attention within the past few years. Houpt and Epstein (1973) have shown that food deprivation stimulates subsequent food intake in suckling rats as early as the first postnatal day of life. Activity is also stimulated by deprivation in the suckling as in the adult rat . Houpt and Epstein, using the glucose analogue 2-deoxy-Dglucose (2DG), and Lytle, Moorcroft, and Campbell (1971), using insulin, have shown that glucoprivation does not stimulate food intake in preweanling rats. These studies indicate that, although the suckling rat possesses one adult control of food intake-the ability to compensate for food deprivation with a subsequent increase in intake-it lacks another adult control--eating in response to a lack of metabolizable glucose. In this respect suckling rats resemble adult rats with lateral hypothalamic lesions, as suggested by Rozin (1969) andRozin (1971).Those factors that depress food intake in 1 The technical assistance of Jack A. Cochrane and the statistical advice of Dale Van Vleck were appreciated.2 K. A. Houpt was a Scholar of the Pennsylvania Plan to Develop Scientists in Medical Research, University of Pennsylvania. Requests for reprints should be sent to K.

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“…Associated with further absorption is a reduction in drinking rate and an eventual termination of drinking (Blass, 1974;Hall & Blass, 1975;Hatton & Bennett, 1970). Accordingly, Hatton and Bennett (1970) and Feider (1972) have suggested that drinking termination in rats is primarily under postabsorptive control.…”

mentioning

confidence: 99%