We quantified the effects of stellar feedback in RCW 49 by determining the physical conditions in different regions using the [C ii] 158 μm and [O i] 63 μm observations from SOFIA, the 12CO (3–2) observations from APEX, and the H2 line observations from Spitzer telescopes. Large maps of RCW 49 were observed with the SOFIA and APEX telescopes, while the Spitzer observations were only available toward three small areas. From our qualitative analysis, we found that the H2 0–0 S(2) emission line probes denser gas compared to the H2 0–0 S(1) line. In four regions (“northern cloud,” “pillar,” “ridge,” and “shell”), we compared our observations with the updated PDR Toolbox models and derived the integrated far-ultraviolet flux between 6 and 13.6 eV (G
0), H nucleus density (n), temperatures, and pressures. We found the ridge to have the highest G
0 (2.4 × 103 Habing units), while the northern cloud has the lowest G
0 (5 × 102 Habing units). This is a direct consequence of the location of these regions with respect to the Wd2 cluster. The ridge also has a high density (6.4 × 103 cm−3), which is consistent with its ongoing star formation. Among the Spitzer positions, we found the one closest to the Wd2 cluster to be the densest, suggesting an early phase of star formation. Furthermore, the Spitzer position that overlaps with the shell was found to have the highest G
0, and we expect this to be a result of its proximity to an O9V star.