2022
DOI: 10.1101/2022.04.01.486519
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Feedback linking cell envelope stiffness, curvature, and synthesis enables robust rod-shaped bacterial growth

Abstract: Bacterial growth is remarkably robust to environmental fluctuations, yet the mechanisms of growth-rate homeostasis are poorly understood. Here, we combine theory and experiment to infer mechanisms by which Escherichia coli adapts its growth rate in response to changes in osmolarity, a fundamental physicochemical property of the environment. The central tenet of our theoretical model is that cell-envelope expansion is only sensitive to local information such as enzyme concentrations, cell-envelope curvature, an… Show more

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“…All data are included in the manuscript and/or SI Appendix , or available at https://doi.org/10.7910/DVN/E1I6CF ( 40 ).…”
Section: Data Materials and Software Availabilitymentioning
confidence: 99%
“…All data are included in the manuscript and/or SI Appendix , or available at https://doi.org/10.7910/DVN/E1I6CF ( 40 ).…”
Section: Data Materials and Software Availabilitymentioning
confidence: 99%